{"id":2,"date":"2018-01-12T00:07:39","date_gmt":"2018-01-12T00:07:39","guid":{"rendered":"http:\/\/gero.usc.edu\/labs\/benayounlab\/?page_id=2"},"modified":"2026-05-14T01:16:57","modified_gmt":"2026-05-14T01:16:57","slug":"benayounlab","status":"publish","type":"page","link":"https:\/\/gero.usc.edu\/labs\/benayounlab\/","title":{"rendered":"The Benayoun Lab"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text css=&#8221;&#8221;]Research in the Benayoun lab focuses on the study of how aging influences genomic regulation, and in return, how modulation of the epigenome and transcriptome can influence the aging process, as well as the development of age-related disease (<em>e.g<\/em>. Alzheimer&#8217;s). To study this question, we use a unique combination of high-throughput &#8216;omics&#8217; approaches, machine-learning, and experimental validation in vertebrate models (<em>e.g<\/em>. mouse, African turquoise killifish, human cells, etc.). Our goal is to discover novel target genes and pathways playing a fundamental role in healthy and pathological aging by leveraging the power of big data.<\/p>\n<p>The Benayoun lab is part of\u00a0<a href=\"https:\/\/gero.usc.edu\/\" target=\"_blank\" rel=\"noopener noreferrer\">the USC Leonard Davis School of Gerontology<\/a>, is affiliated to the <a href=\"https:\/\/keck.usc.edu\/cancer-biology\/\">Department of Cancer Biology at the USC Keck School of Medicine<\/a>, <a href=\"https:\/\/stemcell.usc.edu\/\">USC Stem Cell<\/a> ,\u00a0 the <a href=\"https:\/\/uscnorriscancer.usc.edu\/\">USC Norris Comprehensive Cancer Center<\/a> and the <a href=\"https:\/\/mann.usc.edu\/departments\/pharmacology-pharmaceutical-sciences-department\/\">Department of Pharmacology and Pharmaceutical Sciences at the USC Mann School of Pharmacy and Pharmaceutical Sciences<\/a>.[\/vc_column_text][vc_empty_space height=&#8221;15px&#8221;][vc_separator][\/vc_column][\/vc_row][vc_section][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_row_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;1365&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css=&#8221;&#8221; link=&#8221;https:\/\/gero.usc.edu\/faculty\/berenice-benayoun-phd\/&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;2\/3&#8243;][vc_column_text css=&#8221;&#8221; el_id=&#8221;pi-contact-info&#8221;]<\/p>\n<h3 class=\"faculty-title\"><a href=\"https:\/\/gero.usc.edu\/faculty\/berenice-benayoun-phd\/\">B\u00e9r\u00e9nice Benayoun, PhD<\/a><\/h3>\n<p><strong>Associate Professor of Gerontology, Biological Sciences and Cancer Biology and Pharmacology &amp; Pharmaceutical Sciences<\/strong><\/p>\n<p><strong>Email:<\/strong> <a href=\"mailto:bbenayou@usc.edu\">bbenayou@usc.edu<\/a><br \/>\n<strong>Office Location: <\/strong>GER B14[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_column_text css=&#8221;&#8221;]<strong>Research Interests:<\/strong><\/p>\n<ul>\n<li>Sex differences in Aging and Age-related Disease<\/li>\n<li>Brain Aging and Neurodegeneration<\/li>\n<li>Ovarian Aging and Menopause<\/li>\n<li>Machine Learning and Big Data<\/li>\n<li>Vertebrate Model Organisms<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text]<\/p>\n<h3 style=\"text-align: left;\">Focus Areas<\/h3>\n<p>[\/vc_column_text][vc_row_inner content_placement=&#8221;middle&#8221; css=&#8221;.vc_custom_1516668927034{padding-bottom: 10px !important;}&#8221;][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;41&#8243; img_size=&#8221;&#8221; alignment=&#8221;right&#8221; onclick=&#8221;custom_link&#8221; link=&#8221;https:\/\/gero.usc.edu\/labs\/benayounlab\/research-interests\/&#8221; el_class=&#8221;focus-areas-icons&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;][vc_column_text css=&#8221;&#8221; el_class=&#8221;focus-areas-links&#8221;]<\/p>\n<p class=\"font_8\" style=\"text-align: left;\"><a href=\"https:\/\/gero.usc.edu\/labs\/benayounlab\/research-interests\/\"><strong>Aging, Age-related Disease and &#8216;omic&#8217; Regulation<\/strong><\/a><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner content_placement=&#8221;middle&#8221; css=&#8221;.vc_custom_1516668940930{padding-bottom: 10px !important;}&#8221;][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;42&#8243; img_size=&#8221;&#8221; alignment=&#8221;right&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; link=&#8221;https:\/\/gero.usc.edu\/labs\/benayounlab\/files\/2018\/06\/African-Turquoise-Killifish.pdf&#8221; el_class=&#8221;focus-areas-icons&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;][vc_column_text css=&#8221;&#8221; el_class=&#8221;focus-areas-links&#8221;]<\/p>\n<p class=\"font_8\" style=\"text-align: left;\"><a href=\"https:\/\/gero.usc.edu\/labs\/benayounlab\/files\/2018\/06\/African-Turquoise-Killifish.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>The African Turquoise Killifish: a naturally Short-Lived Model<\/strong><\/a><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner content_placement=&#8221;middle&#8221;][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;40&#8243; img_size=&#8221;&#8221; alignment=&#8221;right&#8221; onclick=&#8221;custom_link&#8221; link=&#8221;https:\/\/gero.usc.edu\/labs\/benayounlab\/research-interests\/&#8221; el_class=&#8221;focus-areas-icons&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;][vc_column_text el_class=&#8221;focus-areas-links&#8221;]<\/p>\n<p class=\"font_8\" style=\"text-align: left;\"><a href=\"https:\/\/gero.usc.edu\/labs\/benayounlab\/research-interests\/\"><strong>Transcription Regulation and Impairment<\/strong><\/a><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner content_placement=&#8221;middle&#8221;][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;963&#8243; img_size=&#8221;&#8221; alignment=&#8221;right&#8221; onclick=&#8221;custom_link&#8221; link=&#8221;https:\/\/gero.usc.edu\/labs\/benayounlab\/research-interests\/&#8221; el_class=&#8221;focus-areas-icons&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;][vc_column_text css=&#8221;&#8221; el_class=&#8221;focus-areas-links&#8221;]<\/p>\n<p class=\"font_8\" style=\"text-align: left;\"><a href=\"https:\/\/gero.usc.edu\/labs\/benayounlab\/research-interests\/\"><b>Sex differences in aging and age-related disease<\/b><\/a><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_separator][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_column_text]<\/p>\n<h3><a href=\"https:\/\/gero.usc.edu\/labs\/benayounlab\/online-resources\/\">Online Resources <i class=\"fa fa-angle-right\"><\/i><\/a><\/h3>\n<ul>\n<li><a href=\"https:\/\/gero.usc.edu\/labs\/benayounlab\/online-resources\/\">Online Databases<\/a><\/li>\n<li><a href=\"https:\/\/gero.usc.edu\/labs\/benayounlab\/online-resources\/#analytical-tools\">Analytical Tools<\/a><\/li>\n<li><a href=\"https:\/\/gero.usc.edu\/labs\/benayounlab\/online-resources\/\">Other important resources<\/a><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text]<\/p>\n<h3>Recent News<\/h3>\n<p>[\/vc_column_text][vc_raw_html]JTNDYSUyMGNsYXNzJTNEJTIydHdpdHRlci10aW1lbGluZSUyMiUyMGRhdGEtaGVpZ2h0JTNEJTIyNTAwJTIyJTIwZGF0YS10aGVtZSUzRCUyMmxpZ2h0JTIyJTIwZGF0YS1saW5rLWNvbG9yJTNEJTIyJTIzOGQzYjZkJTIyJTIwaHJlZiUzRCUyMmh0dHBzJTNBJTJGJTJGdHdpdHRlci5jb20lMkZCQlBhcmlzMTk4NCUzRnJlZl9zcmMlM0R0d3NyYyUyNTVFdGZ3JTIyJTNFVHdlZXRzJTIwYnklMjBCQlBhcmlzMTk4NCUzQyUyRmElM0UlMjAlM0NzY3JpcHQlMjBhc3luYyUyMHNyYyUzRCUyMmh0dHBzJTNBJTJGJTJGcGxhdGZvcm0udHdpdHRlci5jb20lMkZ3aWRnZXRzLmpzJTIyJTIwY2hhcnNldCUzRCUyMnV0Zi04JTIyJTNFJTNDJTJGc2NyaXB0JTNF[\/vc_raw_html][\/vc_column][\/vc_row][\/vc_section]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=&#8221;&#8221;]Research in the Benayoun lab focuses on the study of how aging influences genomic regulation, and in return, how modulation of the epigenome and transcriptome can influence the aging process, as well as the development of age-related disease (e.g. Alzheimer&#8217;s). To study this question, we use a unique combination of high-throughput &#8216;omics&#8217; approaches, machine-learning, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-full.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Benayoun Lab - The Benayoun Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gero.usc.edu\/labs\/benayounlab\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Benayoun Lab\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text css=&#8221;&#8221;]Research in the Benayoun lab focuses on the study of how aging influences genomic regulation, and in return, how modulation of the epigenome and transcriptome can influence the aging process, as well as the development of age-related disease (e.g. Alzheimer&#8217;s). To study this question, we use a unique combination of high-throughput &#8216;omics&#8217; approaches, machine-learning, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/gero.usc.edu\/labs\/benayounlab\/\" \/>\n<meta property=\"og:site_name\" content=\"The Benayoun Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-14T01:16:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/gero.usc.edu\/labs\/benayounlab\/files\/2018\/01\/benayounlab-bg.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1472\" \/>\n\t<meta property=\"og:image:height\" content=\"300\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"The Benayoun Lab\" \/>\n<meta name=\"twitter:image\" content=\"http:\/\/gero.usc.edu\/labs\/benayounlab\/files\/2018\/01\/benayounlab-bg.png\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/benayounlab\\\/\",\"url\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/benayounlab\\\/\",\"name\":\"The Benayoun Lab - The Benayoun Lab\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/benayounlab\\\/#website\"},\"datePublished\":\"2018-01-12T00:07:39+00:00\",\"dateModified\":\"2026-05-14T01:16:57+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/benayounlab\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/benayounlab\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/benayounlab\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/benayounlab\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The Benayoun Lab\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/benayounlab\\\/#website\",\"url\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/benayounlab\\\/\",\"name\":\"The Benayoun Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/benayounlab\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The Benayoun Lab - The Benayoun Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/gero.usc.edu\/labs\/benayounlab\/","og_locale":"en_US","og_type":"article","og_title":"The Benayoun Lab","og_description":"[vc_row][vc_column][vc_column_text css=&#8221;&#8221;]Research in the Benayoun lab focuses on the study of how aging influences genomic regulation, and in return, how modulation of the epigenome and transcriptome can influence the aging process, as well as the development of age-related disease (e.g. Alzheimer&#8217;s). 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