{"id":196,"date":"2020-04-06T20:24:13","date_gmt":"2020-04-06T20:24:13","guid":{"rendered":"https:\/\/gero.usc.edu\/labs\/curranlab\/?page_id=196"},"modified":"2024-02-21T22:37:47","modified_gmt":"2024-02-21T22:37:47","slug":"about","status":"publish","type":"page","link":"https:\/\/gero.usc.edu\/labs\/curranlab\/","title":{"rendered":"About the Curran Lab"},"content":{"rendered":"

[vc_row full_height=”yes” columns_placement=”top”][vc_column width=”2\/3″][vc_column_text]<\/p>\n

About the Curran Lab<\/strong><\/h1>\n

[\/vc_column_text][vc_column_text]Our long-term goal is to generate blueprints that allow an individual to maximize health over the course of their lifespan. Informed by genetics, we develop the capacity to predict which diets are ideal for a healthy life and which should be avoided. Moreover, we investigate the mechanistic basis of the molecules, genes, and pathways we have discovered can influence healthspan. The product of this investment is the ability to use diet as a means to circumvent genetic predisposition and prevent or reduce the severity of age-related disease. Our research has benefited from the ability to quickly test several diet-gene pairs in C. elegans<\/em>, which has allowed us to transition to directed studies in murine models. Although we will continue to exploit the utility of genetics and biochemistry of the worm, we expect that our mouse and cultured human cell approaches will synergize and provide relevant information for human aging.[\/vc_column_text][vc_tta_pageable no_fill_content_area=”1″ autoplay=”5″ active_section=”1″ title=”Recent Discoveries” el_class=”recent-disc”][vc_tta_section title=”Section” tab_id=”1586644565478-048e0737-752d”][vc_row_inner equal_height=”yes” gap=”10″][vc_column_inner width=”1\/4″][vc_single_image image=”833″ img_size=”200×400″ alignment=”right” onclick=”custom_link” img_link_target=”_blank” link=”https:\/\/elifesciences.org\/articles\/52899″][\/vc_column_inner][vc_column_inner width=”3\/4″][vc_column_text]<\/p>\n

WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus<\/span><\/a><\/h3>\n

Jiahui Liu, Chatrawee Duangjan, Ronald W. Irwin, Sean P. Curran[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][vc_tta_section title=”Section” tab_id=”1586644700601-a6c78c92-fe03″][vc_row_inner gap=”10″][vc_column_inner width=”1\/4″ css=”.vc_custom_1586731396977{background-color: #000000 !important;}”][vc_single_image image=”521″ img_size=”400X50″ alignment=”right” onclick=”custom_link” img_link_target=”_blank” link=”https:\/\/www.pnas.org\/content\/116\/44\/22322.long”][\/vc_column_inner][vc_column_inner width=”3\/4″][vc_column_text]<\/p>\n

A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons<\/a><\/h3>\n

Chris D Turner,\u00a0<\/span><\/span>Nicole L Stuhr,\u00a0<\/span><\/span>Carmen M Ramos,\u00a0<\/span><\/span>Bennett T Van Camp,\u00a0<\/span><\/span>Sean P Curran<\/span>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][vc_tta_section title=”Section” tab_id=”1586644697494-9eb20877-ee06″][vc_row_inner gap=”10″][vc_column_inner width=”1\/4″][vc_single_image image=”520″ img_size=”300X100″ alignment=”right” onclick=”custom_link” img_link_target=”_blank” link=”https:\/\/www.nature.com\/articles\/s41598-019-48286-y”][\/vc_column_inner][vc_column_inner width=”3\/4″][vc_column_text]<\/p>\n

Genetic variation in ALDH4A1 is associated with muscle health over the lifespan and across species<\/a><\/h4>\n

Osvaldo Villa*, Nicole L Stuhr*, Chia-an Yen*, Eileen M Crimmins, Thalida Em Arpawong, Sean P Curran[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][vc_tta_section title=”Section” tab_id=”1586644676580-4a7227a8-ac28″][vc_row_inner gap=”10″][vc_column_inner width=”1\/4″][vc_single_image image=”835″ img_size=”200×400″ alignment=”right” onclick=”custom_link” img_link_target=”_blank” link=”https:\/\/academic.oup.com\/biomedgerontology\/article\/74\/8\/1189\/5368940″][\/vc_column_inner][vc_column_inner width=”3\/4″][vc_column_text]<\/p>\n

Loss of WDR23 proteostasis impacts mitochondrial homeostasis in the mouse brain<\/span><\/a><\/h3>\n

Chatrawee Duangjan, Ronald W. Irwin, Sean P. Curran[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][vc_tta_section title=”Section” tab_id=”1586644675698-08dad5f5-ada9″][vc_row_inner gap=”10″][vc_column_inner width=”1\/4″][vc_single_image image=”839″ img_size=”300×400″ alignment=”right” onclick=”custom_link” img_link_target=”_blank” link=”https:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1007520″][\/vc_column_inner][vc_column_inner width=”3\/4″][vc_column_text]<\/p>\n

Comparative analysis of the molecular and physiological consequences of constitutive SKN-1 activation<\/a><\/h3>\n

Carmen M Ramos, Sean P Curran[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tta_section][\/vc_tta_pageable][vc_separator border_width=”2″][vc_row_inner][vc_column_inner width=”1\/2″][vc_single_image image=”593″ img_size=”400×150″][\/vc_column_inner][vc_column_inner width=”1\/2″][vc_column_text]<\/p>\n

Contact us<\/strong><\/h1>\n

Lab Phone:<\/strong>\u00a0(213) 740-9026<\/p>\n

Mailing Address: <\/strong>
\nCurran Lab
\nUniversity of Southern California
\nLeonard Davis School of Gerontology
\n3715 McClintock Ave.
\nLos Angeles, CA. 90089[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”1\/3″][vc_column_text]<\/p>\n

Announcements<\/strong><\/h1>\n

[\/vc_column_text][vc_separator][vc_column_text]<\/p>\n

Congratulation Chris Turner and Carmen Ramos for their SKN-1 review article being accepted at Frontiers in Genetics (link coming soon)<\/h4>\n

[\/vc_column_text][vc_separator][vc_column_text]<\/p>\n

Congratulations Dr. Chatrawee Duangjan for her manuscript in Cell Signalling<\/a>!<\/h4>\n

<\/h4>\n

[\/vc_column_text][vc_separator][vc_column_text]<\/p>\n

Congratulations Dr. Chris Turner for their manuscript in PNAS<\/a>!<\/h4>\n

[\/vc_column_text][vc_separator][vc_column_text]<\/p>\n

Congratulations Brandy Weathers for appointment to the Multidisciplinary T32!<\/h4>\n

[\/vc_column_text][vc_separator][vc_column_text]<\/p>\n

Congratulations Dr. Jiahui Liu for her manuscript in Mechanisms of Ageing and Development<\/a>!<\/h4>\n

[\/vc_column_text][vc_separator][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

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