{"id":10,"date":"2023-09-27T01:36:07","date_gmt":"2023-09-27T01:36:07","guid":{"rendered":"https:\/\/gero.usc.edu\/labs\/hilllab\/?page_id=10"},"modified":"2026-01-21T02:43:21","modified_gmt":"2026-01-21T02:43:21","slug":"the-hill-lab","status":"publish","type":"page","link":"https:\/\/gero.usc.edu\/labs\/hilllab\/","title":{"rendered":"The Hill Lab"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text]<div id=\"metaslider-id-35\" style=\"width: 100%;\" class=\"ml-slider-3-107-0 metaslider metaslider-flex metaslider-35 ml-slider has-dots-nav ms-theme-default\" role=\"region\" aria-label=\"Home Page\" data-height=\"300\" data-width=\"700\">\n    <div id=\"metaslider_container_35\">\n        <div id=\"metaslider_35\">\n            <ul class='slides'>\n                <li style=\"display: block; width: 100%;\" class=\"slide-59 ms-image \" aria-roledescription=\"slide\" data-date=\"2023-09-27 02:01:27\" data-filename=\"iStock-1497761444-scaled-700x300.jpeg\" data-slide-type=\"image\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/gero.usc.edu\/labs\/hilllab\/files\/2023\/09\/iStock-1497761444-scaled-700x300.jpeg\" height=\"300\" width=\"700\" alt=\"Adipose tissue picture\" class=\"slider-35 slide-59 msDefaultImage\" title=\"Adipose tissue human, Soft palate human, Bone human and Striated (skeletal) muscle human.\" \/><div class=\"caption-wrap\"><div class=\"caption\"><h3 style=\"color:#FFFFFF;\">Welcome to the Hill Lab<\/h3>Learn about our research, people, research opportunities and more.<\/div><\/div><\/li>\n                <li style=\"display: none; width: 100%;\" class=\"slide-60 ms-image \" aria-roledescription=\"slide\" data-date=\"2023-09-27 02:01:31\" data-filename=\"iStock-1184397025-cells-scaled-700x300.jpg\" data-slide-type=\"image\"><a href=\"https:\/\/gero.usc.edu\/labs\/hilllab\/research-opportunities\/\" target=\"_self\" aria-label=\"View Slide Details\" class=\"metaslider_image_link\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/gero.usc.edu\/labs\/hilllab\/files\/2023\/09\/iStock-1184397025-cells-scaled-700x300.jpg\" height=\"300\" width=\"700\" alt=\"embryonic stem cells\" class=\"slider-35 slide-60 msDefaultImage\" title=\"Creative image of embryonic stem cells\" \/><\/a><div class=\"caption-wrap\"><div class=\"caption\"><h3 style=\"color:#FFFFFF;\">Join the Lab<\/h3>Explore research opportunities and current openings.<\/div><\/div><\/li>\n            <\/ul>\n        <\/div>\n        \n    <\/div>\n<\/div>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1731539401567{padding-right: 25px !important;padding-left: 25px !important;}&#8221;][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_column_text]The central focus of the Hill Lab investigates the distinctive impact of dietary protein on adipose tissue function. Commonly known as body fat, adipose tissue is a critical regulator of energy and glucose homeostasis. However, aging and obesity contribute to various impairments within adipose tissue that are detrimental to optimal health. Diets that either reduce caloric (CR) intake or alter the intake of amino acids, including dietary protein restriction (DPR) defends against the detriments of aging and obesity. Our lab uses a model of DPR to determine the adaptive response of adipose tissue. Likewise, we aim to determine the impact of DPR on adipose-specific, distant from liver, transcriptional programs that regulate metabolic and endocrine health during aging.[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/6&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_separator][\/vc_column][\/vc_row][vc_row gap=&#8221;35&#8243; css=&#8221;.vc_custom_1731539386272{margin-top: 10px !important;margin-right: 25px !important;margin-bottom: 10px !important;margin-left: 25px !important;padding-top: 15px !important;padding-right: 15px !important;padding-bottom: 15px !important;padding-left: 15px !important;}&#8221;][vc_column width=&#8221;1\/5&#8243;][\/vc_column][vc_column width=&#8221;1\/5&#8243;][vc_single_image image=&#8221;97&#8243; img_size=&#8221;150X150&#8243; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; css=&#8221;&#8221; link=&#8221;http:\/\/gero.usc.edu\/faculty\/andrei-irimia-ph-d\/&#8221;][vc_column_text css=&#8221;&#8221;]<\/p>\n<h3 class=\"faculty-title\"><a href=\"https:\/\/gero.usc.edu\/faculty\/cristal-m-hill-phd\/\">Cristal M. Hill, PhD<\/a><\/h3>\n<p>[\/vc_column_text][vc_column_text css=&#8221;&#8221; el_id=&#8221;pi-contact-info&#8221;]Associate Professor of Gerontology<br \/>\nUSC Leonard Davis School of Gerontology<\/p>\n<p><strong>Email:<\/strong>\u00a0 cristalh@usc.edu[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/5&#8243;][vc_column_text css=&#8221;&#8221;]<\/p>\n<h3><a href=\"https:\/\/gero.usc.edu\/labs\/irimialab\/news\/\">Recent News<\/a><\/h3>\n<div class=\"feedzy-b71707dda24acc78aeb4eb4c51dd3f0c feedzy-rss\"><ul><li  style=\"padding: 15px 0 25px\" class=\"rss_item\"><span class=\"title\"><a href=\"https:\/\/gero.usc.edu\/2024\/07\/24\/cristal-hill-receives-gsa-nathan-shock-new-investigator-award\/\" target=\"_blank\" rel=\" noopener\">Cristal Hill Receives GSA Nathan Shock New Investigator Award<\/a><\/span><div class=\"rss_content\" style=\"\"><small>on July 24, 2024 <\/small><\/div><\/li><li  style=\"padding: 15px 0 25px\" class=\"rss_item\"><span class=\"title\"><a href=\"https:\/\/gero.usc.edu\/2024\/02\/16\/usc-leonard-davis-school-black-history-month-event-features-traditions-passed-down-from-generations-before\/\" target=\"_blank\" rel=\" noopener\">USC Leonard Davis School Black History Month Event Features Traditions Passed Down from Generations Before<\/a><\/span><div class=\"rss_content\" style=\"\"><small>on February 16, 2024 <\/small><\/div><\/li><li  style=\"padding: 15px 0 25px\" class=\"rss_item\"><span class=\"title\"><a href=\"https:\/\/gero.usc.edu\/2024\/01\/11\/supporting-the-future-of-the-field\/\" target=\"_blank\" rel=\" noopener\">Supporting the Future of the Field<\/a><\/span><div class=\"rss_content\" style=\"\"><small>on January 12, 2024 <\/small><\/div><\/li><li  style=\"padding: 15px 0 25px\" class=\"rss_item\"><span class=\"title\"><a href=\"https:\/\/gero.usc.edu\/2024\/01\/11\/eat-well-age-well\/\" target=\"_blank\" rel=\" noopener\">Eat Well, Age Well<\/a><\/span><div class=\"rss_content\" style=\"\"><small>on January 12, 2024 <\/small><\/div><\/li><li  style=\"padding: 15px 0 25px\" class=\"rss_item\"><span class=\"title\"><a href=\"https:\/\/gero.usc.edu\/2023\/11\/30\/new-faculty-faces\/\" target=\"_blank\" rel=\" noopener\">New Faculty Faces<\/a><\/span><div class=\"rss_content\" style=\"\"><small>on December 1, 2023 <\/small><\/div><\/li><\/ul> <\/div><style type=\"text\/css\" media=\"all\">.feedzy-rss .rss_item .rss_image{float:left;position:relative;border:none;text-decoration:none;max-width:100%}.feedzy-rss .rss_item .rss_image span{display:inline-block;position:absolute;width:100%;height:100%;background-position:50%;background-size:cover}.feedzy-rss .rss_item .rss_image{margin:.3em 1em 0 0;content-visibility:auto}.feedzy-rss ul{list-style:none}.feedzy-rss ul li{display:inline-block}<\/style>[\/vc_column_text][vc_btn title=&#8221;More news&#8221; style=&#8221;custom&#8221; custom_background=&#8221;#464646&#8243; custom_text=&#8221;#FFFFFF&#8221; link=&#8221;url:https%3A%2F%2Fgero.usc.edu%2Ftag%2Fhill%2F|title:Hill%20Lab%20News|target:_blank&#8221;][\/vc_column][vc_column width=&#8221;1\/5&#8243;][vc_column_text css=&#8221;&#8221;]<\/p>\n<h3>Primary Research Areas<\/h3>\n<ul>\n<li>Biology of aging<\/li>\n<li>Nutrient sensing<\/li>\n<li>Tissue-specific metabolic targets<\/li>\n<li>Macronutrients effects on health-span and lifespan<\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_column_text css=&#8221;&#8221;]<\/p>\n<h3>Follow the Hill Lab<\/h3>\n<p>[\/vc_column_text][vc_raw_html css=&#8221;&#8221;]JTNDYSUyMGNsYXNzJTNEJTIydHdpdHRlci10aW1lbGluZSUyMiUyMGhyZWYlM0QlMjJodHRwcyUzQSUyRiUyRnR3aXR0ZXIuY29tJTJGQ3Jpc3RhbE1fSGlsbCUzRnJlZl9zcmMlM0R0d3NyYyUyNTVFdGZ3JTIyJTNFVHdlZXRzJTIwYnklMjBDcmlzdGFsTV9IaWxsJTNDJTJGYSUzRSUyMCUzQ3NjcmlwdCUyMGFzeW5jJTIwc3JjJTNEJTIyaHR0cHMlM0ElMkYlMkZwbGF0Zm9ybS50d2l0dGVyLmNvbSUyRndpZGdldHMuanMlMjIlMjBjaGFyc2V0JTNEJTIydXRmLTglMjIlM0UlM0MlMkZzY3JpcHQlM0U=[\/vc_raw_html][\/vc_column][vc_column width=&#8221;1\/5&#8243;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text][\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1731539401567{padding-right: 25px !important;padding-left: 25px !important;}&#8221;][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_column_text]The central focus of the Hill Lab investigates the distinctive impact of dietary protein on adipose tissue function. Commonly known as body fat, adipose tissue is a critical regulator of energy and glucose homeostasis. However, aging and obesity contribute to various impairments within adipose tissue that are detrimental [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-nopadding.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-10","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Hill Lab - The Hill Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gero.usc.edu\/labs\/hilllab\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Hill Lab - The Hill Lab\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text][\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1731539401567{padding-right: 25px !important;padding-left: 25px !important;}&#8221;][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_column_text]The central focus of the Hill Lab investigates the distinctive impact of dietary protein on adipose tissue function. Commonly known as body fat, adipose tissue is a critical regulator of energy and glucose homeostasis. However, aging and obesity contribute to various impairments within adipose tissue that are detrimental [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/gero.usc.edu\/labs\/hilllab\/\" \/>\n<meta property=\"og:site_name\" content=\"The Hill Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-21T02:43:21+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/hilllab\\\/\",\"url\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/hilllab\\\/\",\"name\":\"The Hill Lab - The Hill Lab\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/hilllab\\\/#website\"},\"datePublished\":\"2023-09-27T01:36:07+00:00\",\"dateModified\":\"2026-01-21T02:43:21+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/hilllab\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/hilllab\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/hilllab\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/hilllab\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The Hill Lab\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/hilllab\\\/#website\",\"url\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/hilllab\\\/\",\"name\":\"The Hill Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/hilllab\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The Hill Lab - The Hill Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/gero.usc.edu\/labs\/hilllab\/","og_locale":"en_US","og_type":"article","og_title":"The Hill Lab - The Hill Lab","og_description":"[vc_row][vc_column][vc_column_text][\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1731539401567{padding-right: 25px !important;padding-left: 25px !important;}&#8221;][vc_column width=&#8221;1\/6&#8243;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_column_text]The central focus of the Hill Lab investigates the distinctive impact of dietary protein on adipose tissue function. 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