{"id":11,"date":"2019-06-22T18:12:02","date_gmt":"2019-06-22T18:12:02","guid":{"rendered":"https:\/\/gero.usc.edu\/labs\/leelab\/?page_id=11"},"modified":"2022-04-01T22:38:07","modified_gmt":"2022-04-01T22:38:07","slug":"publications","status":"publish","type":"page","link":"https:\/\/gero.usc.edu\/labs\/leelab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text]Ko S, Yeom E, Chun YL, Mun H, Howard-McGuire M, Millison NT, Jung J, Lee KP, Lee C<\/strong>, Lee KS, Delaney JR, Yoon JH. Profiling of RNA-binding proteins interacting with glucagon and adipokinetic hormone mRNAs. J Lipid Atheroscler, 10:e28 (2021).<\/p>\n

Kong BS, Min SH,\u00a0Lee C*<\/strong>, Cho YM*. Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes.\u00a0Cell Reports,\u00a0In Press (2021).\u00a0*Co-corresponding<\/p>\n

Kang GM, Min SH, Lee CH, Kim JY, Lim HS, Jung SB, Park JW, Kim SJ, Park CB, Hong D, Choi JH, Jang WH, Park SE, Cho YM, Kim JG, Kim KG, Choi CS, Kim YB,\u00a0Lee C*<\/strong>, Shong MH*, Kim MS*. Mitohormesis in hypothalamic POMC neurons mediates regular exercise-induced high-turnover metabolism.\u00a0Cell Metabolism,\u00a0In Press (2021).
\n*Co-corresponding<\/p>\n

Reynolds JC, Lai RL, Woodhead J, Joly J, Mitchell CJ, Cameron-Smith D, Cohen P, Lu R, Graham N, Benayoun BA, Merry T,\u00a0Lee C<\/strong>. Reversal of Age-Dependent Physical Decline by the Exercise-Induced Mitochondrial-Encoded Peptide MOTS-c.\u00a0Nature Communications<\/em>,\u00a0In Press (2021).\u200b<\/span><\/p>\n

Kwon SM, Min SK, Jeoun UW, Sim MS, Jung GH, Jee BA, Woo HG,\u00a0Lee C<\/strong>,\u00a0Yoon GS. Global spliceosome activity regulates entry into cellular senescence.\u00a0FASEB J<\/em>, In Press (2020)\u200b<\/span><\/p>\n

Merry TL, Chan A, Woodhead JST, Reynolds JC, Kumagai H, Kim SJ,\u00a0Lee C<\/strong>. Mitochondrial-derived peptides in energy metabolism. Am J Physiol Endocrinol Metab. 319:E659-E666 (2020).<\/p>\n

Reynolds JC, Lai RL, Woodhead J, Joly J, Mitchell CJ, Cameron-Smith D, Cohen P, Lu R, Graham N, Benayoun BA, Merry T, Lee C<\/strong>. Reversal of Age-Dependent Physical Decline by the Exercise-Induced Mitochondrial-Encoded Peptide MOTS-c. bioRxiv<\/em>. (2019). Under Peer Review<\/em> (2020).<\/p>\n

Zempo H, Kim SJ, Fuku N, Nishida Y, Higaki Y, Wan J, Yen K, Miller B, Vicinanza R, Miyamoto-Mikami E, Kumagai H, Naito H, Xiao J, Mehta HH, Lee C<\/strong>, Hara M, Patel YM, Setiawan VW, Moore T, Hevener A, Sutoh Y, Shimizu A, Kojima K, Kinoshita K, Tanaka K, Cohen P. A Pro-Diabetogenic mtDNA Polymorphism in the Mitochondrial-Derived Peptide, MOTS-c. bioRxiv (2019). Under Peer Review<\/em> (2020).<\/p>\n

D\u2019Souza RF, Woodhead JST, Hedges CP, Zeng N, Humagai H, Lee C<\/strong>, Cohen P, Cameron-Smith D, Mitchell CJ, Merry TL. Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition. Aging<\/em>, In Press (2020).<\/p>\n

Chen Y*, Bravo JI*, Son JM, Lee C<\/strong>, Benayoun BA. Remodeling of the H3 nucleosomal landscape during mouse aging. Translational Medicine of Aging<\/em> 4:22-31 (2020). *Equal Contribution<\/p>\n

Reynold JC, Bwiza CP, Lee C<\/strong>. Mitonuclear genomics and aging. Human Genetics<\/em> 139:381-399 (2020).
\nRecommended F1000Prime: Osiewacz H, 10.3410\/f.737293312.793571684 (2020).<\/em><\/p>\n

Son JM and Lee C<\/strong>. Mitochondria: multifaceted regulators of aging. BMB Reports<\/em> 52:13-23 (2019).\u200b<\/p>\n

Benayoun BA and Lee C<\/strong>. MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus. Bioessays<\/em>, 41(9):e1900046 (2019).\u200b<\/p>\n

Lee C<\/strong>. Nuclear Transcriptional Regulation by Mitochondrial-Encoded MOTS-c. Molecular & Cellular Oncology<\/em> 6:1549464 (2019).\u200b<\/p>\n

Kim SJ, Chun M, Wan J, Lee C<\/strong>, Yen K, Cohen P. GRSF1 is an age-related regulator of senescence. Scientific Reports<\/em> 9:5546 (2019).<\/p>\n

Kim, KH, Son JM, Benayoun BA, and Lee C<\/strong>. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metabolism<\/em> 28:516-524 (2018).
\nCovered: A mitochondrial-derived peptide exercises the nuclear option. Cell Metabolism 28:330-331 (2018).<\/em>
\nCovered: Going nuclear with stress. Science Signaling 11:eaav4285 (2018).<\/em><\/p>\n

\u200bLee YK, Lim JJ, Jeoun UW, Min S, Lee EB, Kwon SM, Lee C<\/strong>, Yoon G. Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness. J Biol Chem<\/em> 292:20208-20217 (2017).<\/p>\n

Di Biase S*, Shim HS*, Kim KH*, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Lee C<\/strong>, Longo VD. Fasting Regulates EGR1 and Protects from Glucose-and Dexamethasone Dependent Sensitization to Chemotherapy. PLoS Biology<\/em>. In Press (2017). * Equal Contribution<\/p>\n

Choi IY, Lee C<\/strong>, Longo VD. Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence. Mol Cell Endocrinol<\/em>. In Press (2017).<\/p>\n

Di Biase S*, Lee C<\/strong>*, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan T, Longo VD. Fasting mimicking diet-dependent HO-1 reduction promotes T cell-mediated tumor cytotoxicity. Cancer Cell<\/em> 30:136-46 (2016). *Equal Contribution<\/p>\n

Lee C<\/strong>* and Longo VD*. Growth Hormones and aging. In: Principles of endocrinology and hormone action (Editor: Derek LeRoith and Antonino Belfiore). 2016. (Springer). *Co-corresponding author<\/p>\n

Cobb LJ, Lee C<\/strong>, Nakamura HK, Mehta H, Hosono H, Wan J, Gao Q, Ashur C, Muzumdar R, Hwang D, Barzilai N, Cohen P. Naturally Occurring Mitochondrial-Derived Peptides Are Regulators of Physiological Processes. Aging<\/em> 8:796-809 (2016).<\/p>\n

Lee C<\/strong>, Kim K, Cohen P. MOTS-c: a novel mitochondrial-derived peptide regulating muscle metabolism. Free Radic Biol Med<\/em>. Epub ahead of time (2016).<\/p>\n

Lee C<\/strong>* and Longo VD*. Dietary restriction with and without caloric restriction for healthy aging. F1000 Research Review<\/em> (2016). *Co-corresponding author<\/p>\n

Lee C<\/strong> and Longo VD. The Impact of Cancer Treatments on Aging. In: Advances in Geroscience (Editor: Felipe Sierra and Ronald Kohanski; 2015). National Institute on Aging (Springer).<\/p>\n

Lee C<\/strong>*, Zeng J, Drew BG, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P*. The Mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism 21: 443-454 (2015). *Co-corresponding author
\nCovered: A Mitochondrially Encoded Hormone Ameliorates Obesity and Insulin Resistance.<\/em>
\nCell Metabolism 21: 355-356 (2015)<\/em><\/p>\n

Lee C<\/strong>, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo VD, Bartke A, Cohen P. IGF-I Regulates the Age-Dependent Mitochondrial Peptide Humanin. Aging Cell<\/em> 13:958-961 (2014).<\/p>\n

Lee C<\/strong>, Yen K, and Cohen P. Humanin: a harbinger of mitochondrion-derived peptides? Trends in Endocrinology and Metabolism<\/em> 24:222-8 (2013).<\/p>\n

Yen K, Lee C<\/strong>, Mehta H, Cohen P. The emerging role of the mitochondria-derived peptide Humanin in stress resistance. Journal of Molecular Endocrinology<\/em> 50:1, R11-R19 (2012).<\/p>\n

Safdie FM, Brandhorst S, Wei M, Wang W, Lee C<\/strong>, Hwang S, Chen TC, and Longo VD. Fasting Enhances the Response of Glioma to Radio- and Chemotherapy. PLoS One 7<\/em>:e44603 (2012).<\/p>\n

Lee C<\/strong>, Raffaghello L, and Longo VD. Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resistance Updates<\/em> 15:114-122 (2012).<\/p>\n

Lee C<\/strong>, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Science translational medicine<\/em> 4, 124ra127 (2012).
\nCovered: Impersonalized Medicine. Sci Transl Med 4:124ps6 (2012).<\/em>
\nToxicity in chemotherapy-when less is more. N Engl J Med. 366:2319-20 (2012).<\/em><\/p>\n

Lee C<\/strong>, and Longo VD. Fasting Dietary Restriction in Cellular Protection and Cancer treatment: from model systems to patients. Oncogene<\/em> 30:3305-16 (2011).<\/p>\n

Lee C,<\/strong> Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Research<\/em> 70:1564-72 (2010).<\/p>\n

Safdie FM, Dorff T , Quinn D, Fontana L, Wei M, Lee C<\/strong>, Cohen P, Longo VD. Fasting and Cancer Treatment: Ten Case reports. Aging<\/em> 1:988-1007 (2009).<\/p>\n

Wozniak CE, Lee C<\/strong>, and Hughes KT. T-POP array identifies EcnR and PefI-SrgD as novel regulators of flagellar gene expression. Journal of Bacteriology<\/em> 191:1498-508 (2009).<\/p>\n

Raffaghello L*, Lee<\/strong> C*<\/strong>, Safdie FM, Wei M, Madia F, Bianchi G, & Longo VD. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci U S A<\/em> 105:8215-20 (2008). *Equal Contribution
\nCovered: Can Fasting Blunt Chemotherapy’s Debilitating Side Effects? Science 29: 1146-1147 (2008).<\/em><\/p>\n

Lee<\/strong> C<\/strong>, Wozniak C, Karlinsey JE, & Hughes KT. Genomic screening for regulatory genes using the T-POP transposon. Methods in Enzymology<\/em> 421:159-67 (2007).[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][vc_column_text]Ko S, Yeom E, Chun YL, Mun H, Howard-McGuire M, Millison NT, Jung J, Lee KP, Lee C, Lee KS, Delaney JR, Yoon JH. Profiling of RNA-binding proteins interacting with glucagon and adipokinetic hormone mRNAs. J Lipid Atheroscler, 10:e28 (2021). Kong BS, Min SH,\u00a0Lee C*, Cho YM*. Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"page-full.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-11","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nPublications - The Lee Laboratory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gero.usc.edu\/labs\/leelab\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - The Lee Laboratory\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text]Ko S, Yeom E, Chun YL, Mun H, Howard-McGuire M, Millison NT, Jung J, Lee KP, Lee C, Lee KS, Delaney JR, Yoon JH. Profiling of RNA-binding proteins interacting with glucagon and adipokinetic hormone mRNAs. J Lipid Atheroscler, 10:e28 (2021). Kong BS, Min SH,\u00a0Lee C*, Cho YM*. 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Profiling of RNA-binding proteins interacting with glucagon and adipokinetic hormone mRNAs. J Lipid Atheroscler, 10:e28 (2021). Kong BS, Min SH,\u00a0Lee C*, Cho YM*. Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune […]","og_url":"https:\/\/gero.usc.edu\/labs\/leelab\/publications\/","og_site_name":"The Lee Laboratory","article_modified_time":"2022-04-01T22:38:07+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/gero.usc.edu\/labs\/leelab\/publications\/","url":"https:\/\/gero.usc.edu\/labs\/leelab\/publications\/","name":"Publications - The Lee Laboratory","isPartOf":{"@id":"https:\/\/gero.usc.edu\/labs\/leelab\/#website"},"datePublished":"2019-06-22T18:12:02+00:00","dateModified":"2022-04-01T22:38:07+00:00","breadcrumb":{"@id":"https:\/\/gero.usc.edu\/labs\/leelab\/publications\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/gero.usc.edu\/labs\/leelab\/publications\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/gero.usc.edu\/labs\/leelab\/publications\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/gero.usc.edu\/labs\/leelab\/"},{"@type":"ListItem","position":2,"name":"Publications"}]},{"@type":"WebSite","@id":"https:\/\/gero.usc.edu\/labs\/leelab\/#website","url":"https:\/\/gero.usc.edu\/labs\/leelab\/","name":"The Lee Laboratory","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/gero.usc.edu\/labs\/leelab\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/gero.usc.edu\/labs\/leelab\/wp-json\/wp\/v2\/pages\/11","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gero.usc.edu\/labs\/leelab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/gero.usc.edu\/labs\/leelab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/gero.usc.edu\/labs\/leelab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gero.usc.edu\/labs\/leelab\/wp-json\/wp\/v2\/comments?post=11"}],"version-history":[{"count":0,"href":"https:\/\/gero.usc.edu\/labs\/leelab\/wp-json\/wp\/v2\/pages\/11\/revisions"}],"wp:attachment":[{"href":"https:\/\/gero.usc.edu\/labs\/leelab\/wp-json\/wp\/v2\/media?parent=11"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}