{"id":14,"date":"2021-05-11T20:23:55","date_gmt":"2021-05-11T20:23:55","guid":{"rendered":"https:\/\/gero.usc.edu\/labs\/lifecoglab\/?page_id=14"},"modified":"2026-04-27T16:25:40","modified_gmt":"2026-04-27T23:25:40","slug":"research","status":"publish","type":"page","link":"https:\/\/gero.usc.edu\/labs\/lifecoglab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

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Studies<\/h1>\n

The Lifespan Cognition Lab is enrolling participants in a research study that investigates the role of hormones and persistent organic pollutants on brain health and cognitive function.<\/h2>\n

Participants must be between the ages 40-79, fluent in English, weigh at least 110 lbs, live in the greater Los Angeles area, and be willing and able to come to the lab, donate blood and urine and undergo an MRI scan (up to 1 hour). Other inclusions and exclusion criteria apply.<\/h2>\n

To see if you qualify please click here<\/a>.<\/h2>\n

If you qualify, we will contact you to schedule a time for you to come the lab on the USC campus to complete cognitive testing, donate blood and urine, and complete an MRI scan. \u00a0At home, you will complete additional questionnaires and surveys online.<\/h2>\n

You will receive compensation for participating in the study. Parking at USC will be provided.<\/h2>\n

If you have general questions about the study, please contact Study team by emailing:<\/h2>\n

SageStudy@usc.edu<\/a><\/h2>\n

IRB Protocols USC IRB UP-25-00474 and UP-21-00715<\/h4>\n

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Funding<\/h1>\n

Funding comes from the National Institutes on Aging<\/a> , the Office of Research on Women’s Health<\/a>, and the Alzheimer’s Association<\/a>, the Hansen Thorell Award and the Kathleen Gilmore Biology of Aging Award.<\/h2>\n
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Affiliations<\/h1>\n

Affiliations of the lab include the USC Neuroscience Graduate Program<\/a>, USC Department of Psychology<\/a>, Columbia University Division of Cognitive Neuroscience.<\/a><\/h2>\n

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Publications<\/h1>\n

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Fox, R. Chaudhari, N., Bhattacharya, S., Imms, P., Eich, T., Mack, W. Gatz, M. & Irimia, A. Women\u2019s Reproductive Factors Predict Local Brain Aging Profiles Mapped using Deep Neural Networks. (2026). Geroscience.<\/em><\/h3>\n

Amin, S.,<\/u> Yoon, D.,<\/u> Naveen, R.,<\/u> El-Magharbel, Y.,<\/u> Vincent, A<\/u>., Chien, C.Y.<\/u> & Eich, T (2025). Divergent Effects of Sleep Efficiency and Sleep Medication on Episodic Memory in Mid to Late Life. Frontiers in Sleep.<\/em><\/h3>\n

Chopra, S.<\/u>, Yoon, D<\/u>. & Eich, T. (2025). Views of Menopause and Hormone Therapy Associations with Hormone Therapy use in US Women aged 50-79. Women\u2019s Health Reports.<\/em><\/h3>\n

Pournaghdali, A.<\/u>, & Eich, T. S (2025). Cautionary response strategy and impairment of post- conflict response selection underlie age-related differences in a location-based Stroop task. Frontiers in Psychology: Psychology of Aging<\/em>.<\/h3>\n

Balado, J.J.<\/u>, Habeck, C., Stern, Y. & Eich, T. S. (2024). The relationship between white matter \u00a0\u00a0\u00a0 hyperintensities and cortical thickness in mid to late-life. Neurobiology of Aging.<\/em><\/h3>\n

Chien, J.<\/u> & Eich, T. S. (2024). Does stereotype threat influence age-related differences on directed forgetting tasks? Frontiers in Psychology: Psychology of Aging<\/em>.<\/h3>\n

Eich, T. S., Langfield, C., Sakhardande, J., Gazes, Y., Habeck, C., & Stern, Y. (2023). Older adults compensate for switch, but not mixing costs, relative to younger adults on an intrinsically-cued task switching experiment. Frontiers in Aging Neuroscience<\/em>, 15, 1152582.<\/h3>\n

Corlier, F<\/u>. & Eich, T. S (2023). Principal component analysis reveals multiple dimensions of memory inhibition that are differentially affected by age. Frontiers in Psychology: Psychology \u00a0\u00a0 of Aging<\/em>, 13, 1020915.<\/h3>\n

Schwartz, S.T., Siegel, A.M.,<\/u> Eich, T.S., & Castel, A.D (2022). Value-Directed Memory Selectivity Relies on Goal-Directed Knowledge of Value Structure Prior to Encoding in Young and Older Adults. Psychology and Aging, <\/em>38(1), 30-48<\/h3>\n

Metcalfe, J., Towner, E. & Vuorre, M., Eich, T. S. (2022). Curiosity: The Effects of Feedback and Confidence on the Desire to Know.\u00a0 Journal of Experimental Psychology: General, <\/em>152(2), 464-\u00a0\u00a0\u00a0 482.<\/h3>\n

Balado, J.J., Corlier, F.,<\/u> Habeck, C., Stern, Y. & Eich, T. S. (2022). Effects of White Matter \u00a0 Hyperintensities distribution and clustering on late-life cognitive impairment. Nature Scientific Reports, <\/em>12(1), 1955.<\/h3>\n

Balado, J.J.,<\/u> Ycaza Herrera, A., Igwe, K., Kelm, L<\/u>., Irimia, A., Buyukturkoglu, K., Guo, J., Brickman, A. & Eich, T. S (2021). Lower hippocampal GABA+ is associated with poorer episodic memory in older women: A pilot study. Frontiers in Behavioral Neuroscience,<\/em> 15, 695416, Special Issue: \u201cSex Hormone Fluctuations Across the Female Lifespan: Mechanisms of Action on Brain Structure, Function, and Behavior\u201d.<\/h3>\n

Siegel, A.M<\/u> & Eich, T.S (2021). Age, Sex, and Inhibitory Control: Identifying a Specific Impairment in Memorial, But Not Perceptual, Inhibition in Older Women. Journal of Gerontology B: Psychological Sciences<\/em>, <\/em>76(10), 2013-2022.<\/strong><\/h3>\n

\u00a0Eich, T. S., Lau, P. & Anderson, M. C. (2021). Cortical thinning in the right Inferior Frontal Gyrus mediates age-related performance differences on an item-method directed forgetting task. Neurobiology of Aging, <\/em>106, 95-102.<\/strong><\/h3>\n

Balado, J.J.<\/u> & Eich, T. S. (2021). GABAergic dysfunction, neural network\u00a0hyperactivity\u00a0and memory\u00a0impairments in human aging and Alzheimer\u2019s disease. Seminars in Cell and Developmental Biology, <\/em>116, 146-159, <\/em>Special Issue:\u201c<\/em>Aging in the Nervous System\u201d.<\/h3>\n

Metcalfe, J., Schwartz, B.& Eich, T.S. (2020) Epistemic\u00a0Curiosity\u00a0and the Region of Proximal Learning.Current Opinion in Behavioral Sciences<\/em>, 35, 40-47.<\/h3>\n

\u00a0Eich, T.S., Parker, D., Gazes, Y., Razlighi, Q., Habeck, C., & Stern, Y. (2020). Towards an ontology of cognitive processes and their neural substrates: A structural equation modelling approach. PLOSOne, <\/em>15(2), e0228167.<\/strong><\/h3>\n

Habeck, C., Eich, T.S., Gu, Y & Stern, Y. (2020). Occupational Patterns of Structural Brain Health: Independent Contributions Beyond Age, Gender, Intelligence, and Education. Frontiers in Human Neuroscience, <\/em>13, 449.<\/h3>\n

Eich, T. S., Tsapanou, A., & Stern, Y. (2019). Whentime\u2019sarrow\u00a0doesn\u2019t bend:\u00a0APOE-<\/em>\u03b54 influences episodic memory before old age.\u00a0 Neuropsychologia, <\/em>133, 107180. Special Issue: \u201cEndel Tulving\u201d.<\/h3>\n

Metcalfe, J. & Eich, T.S. (2019). Memory and truth: correcting errors with true feedback versus overwriting correct answers with errors. Cognitive Research: Principles and Implications<\/em>, 4(1), 4.<\/h3>\n

Habeck, C., Eich, T.S., Razlighi, Q., Gazes, Y. & Stern, Y. (2018). Reference ability neural networks and behavioral performance across the adult life span. NeuroImage, <\/em>172, 51-63.<\/h3>\n

Eich, T. S. Razlighi, Q. & Stern,Y. (2017). Perceptual and memory inhibition are associated with region-specific, doubly dissociable patterns of cortical thinning in clinically healthy older adults. Behavioral Neuroscience, <\/em>131(3), 220-5.<\/h3>\n

Razlighi, Q., Oh, H., Habeck, C., O\u2019Shea, D., Gazes, Y., Eich, T., Parker, D., Lee, S. & Stern,Y. (2017). Dynamic patterns of brain structure-behavior correlation across the life span. Cerebral Cortex<\/em>. 27(7), 3586-99.<\/h3>\n

Eich, T. S., Gon\u00e7alves, B., Razlighi, Q., Nee, D. E, Jonides, J. & Stern, Y. (2016). Inhibitory selection mechanisms in clinically healthy older and younger adults. Journal of Gerontology B:Psychological Sciences, <\/em>73(4), 612-21.<\/h3>\n

\u00a0Eich, T. S., MacKay-Brandt , A., Stern, Y & Gopher, D. (2016). Age-based differences in task switching performance costs are moderated by dissociable executive control demands. Journal of Gerontology B: Psychological Sciences<\/em>, 73 (6), 954-63.<\/strong><\/h3>\n

\u00a0Eich, T. S. Parker, D., Liu, D., Oh, H., Razlighi, Q., Gazes, Y., Habeck, C. & Stern,Y. (2016). Functional brain and age-related changes associated with congruency in task switching. Neuropsychologia, <\/em>91, 211-21.<\/strong><\/h3>\n

Eich, T. S. & Castel, A. D. (2016). The cognitive control of emotional versus value-based information in younger and older adults. Psychology & Aging, <\/em>31 (5), 503-12.<\/h3>\n

Tsapanou, A., Gu, Y., O\u2019Shea, D., Eich, T., Tang, M-X., Schupf, N., Manly, J., Scarmeas, N. & Stern, Y. (2016). Daytime somnolence as an early sign of cognitive decline in a community-based study of elderly. International Journal of Geriatric Psychiatry, <\/em>31 (3), 247-55.<\/h3>\n

\u00a0Eich, T. S, Rakitin, B.C. & Stern, Y. (2015). Response-conflict moderates the cognitive control of episodic and contextual load in older adults. Journal of Gerontology B: Psychological Sciences, <\/em>71 (6), 995-1003.<\/strong><\/h3>\n

Eich, T. S., Murayama, K., Castel, A. & Knowlton, B. (2014). The Dynamic Effects of Age-Related Stereotype Threat on Explicit and Implicit Memory Performance in Older Adults. Social Cognition<\/em>, 32 (6), 559-70.<\/h3>\n

Ahmari, S., Eich, T., Cebenoyan, D., Smith, E. E. & Simpson, B. H. (2014) Assessing neurocognitive function in psychiatric disorders: a roadmap for enhancing consensus. Neurobiology of Learning and Memory<\/em>, 115, 10-20. PMID: 24994503<\/h3>\n

\u00a0Eich, T. S., Nee, D., Insel, K., Malapani, C. & Smith, E. E. (2014).\u00a0 Neural correlates of impaired control over working memory in Schizophrenia.\u00a0 Biological Psychiatry<\/em>, 76(2), 146-53.<\/strong><\/h3>\n

\u00a0Eich, T. S. & Smith, E. E. (2014). Schizophrenia and emotional rubbernecking. Cognitive, Affective & Behavioral Neuroscience<\/em>, Special Issue: \u201cEdward Smith\u201d, 14<\/em>(1), 202-8.<\/strong><\/h3>\n

Metcalfe, J, Eich, T. S. & Miele, D. (2013). Metacognition of agency: Proximal action and distal outcome. Experimental Brain Research<\/em>, 229, 485-96.<\/h3>\n

\u00a0Eich, T. S., Metcalfe, J. & Stern, Y. (2012). The hypercorrection effect in younger and older adults. Aging, Neuropsychology, and Cognition<\/em>, 20, 511-21.\u00a0<\/strong><\/h3>\n

\u00a0Eich, T. S & Smith, E. E. (2012). Cognitive Neuroscience.\u00a0 Oxford Bibliographies Online.<\/em><\/strong><\/h3>\n

Smith, E. E., Eich, T. S., Cebenoyan, D. & Malapani, C. (2011). Intact and impaired cognitive control processes in schizophrenia. Schizophrenia Research<\/em>, 126, 132-7.<\/h3>\n

Metcalfe, J., Eich, T. S., & Castel, A. D. (2010) Metacognition of agency across the lifespan:\u00a0\u00a0Similar and differential effects in college students, older adults and children. Cognition,<\/em> 116(2), 267- 282.<\/h3>\n

Kornell, N., Castel, A. D., Eich, T. S., & Bjork, R. A. (2010). Spacing as the friend of both memory \u00a0 and induction in younger and older adults. \u00a0Psychology and Aging, <\/em>25, 498-503.<\/h3>\n

Eich, T. S. & Metcalfe, J. (2009). Effects of the stress of marathon running on implicit and explicit memory. Psychological Bulletin & Review,<\/em> 16, 475-479.<\/strong><\/h3>\n

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