{"id":12,"date":"2019-07-26T17:46:00","date_gmt":"2019-07-26T17:46:00","guid":{"rendered":"https:\/\/gero.usc.edu\/labs\/longolab\/?page_id=12"},"modified":"2025-02-24T18:25:08","modified_gmt":"2025-02-25T02:25:08","slug":"publications","status":"publish","type":"page","link":"https:\/\/gero.usc.edu\/labs\/longolab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

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  1. Longo, VD, Silveira, NMFP, Amorim, MP, Silva, EFD, Baldasso, IS, Fornari, AC et al.<\/i>. Anaerobic Bioconversion of Mixed Fruit Waste into Organic Acids and a Multifunctional Enzymatic Bioproduct in a Stirred-Tank Bioreactor Using Wickerhamomyces<\/i> sp. UFFS-CE-3.1.2. Microorganisms. 2026;14 (4):. doi: 10.3390\/microorganisms14040907<\/a>. PubMed PMID:42075303<\/a> PubMed Central PMC13118420<\/a>.<\/li>
  2. Carbone, F, Scuricini, A, Cabri, M, Liberale, L, Montecucco, F, Catal\u00e1n, V et al.<\/i>. Senescent obesity signature in breast cancer: a paradigm of reverse cardio-oncology. Eur Heart J. 2026; :. doi: 10.1093\/eurheartj\/ehag144<\/a>. PubMed PMID:41885139<\/a> .<\/li>
  3. Kulkarni, C, Fardeen, T, Gubatan, J, Ye, J, Jarr, K, Dickson, E et al.<\/i>. A fasting-mimicking diet in patients with mild-to-moderate Crohn's disease: a randomized controlled trial. Nat Med. 2026;32 (3):1023-1033. doi: 10.1038\/s41591-025-04173-w<\/a>. PubMed PMID:41530382<\/a> .<\/li>
  4. Sulaj, A, Nguyen, PBH, Poschet, G, Kliemank, E, Fleming, T, Henke, L et al.<\/i>. Periodic fasting induced reconstitution of metabolic flexibility improves albuminuria in patients with type 2 diabetes. Mol Metab. 2025;102 :102257. doi: 10.1016\/j.molmet.2025.102257<\/a>. PubMed PMID:41005725<\/a> PubMed Central PMC12546980<\/a>.<\/li>
  5. Mishra, A, Fanti, M, Ge, X, Vaughn, D, Brandhorst, S, Wei, M et al.<\/i>. Author Correction: Fasting mimicking diet cycles versus a Mediterranean diet and cardiometabolic risk in overweight and obese hypertensive subjects: a randomized clinical trial. NPJ Metab Health Dis. 2025;3 (1):38. doi: 10.1038\/s44324-025-00084-z<\/a>. PubMed PMID:40987812<\/a> PubMed Central PMC12457591<\/a>.<\/li>
  6. Roshan, M, Mudrack, C, Sulaj, A, von Rauchhaupt, E, Fleming, T, Schimpfle, L et al.<\/i>. Exploring the Relationship Between Insulin Resistance, Liver Health, and Restrictive Lung Diseases in Type 2 Diabetes. J Pers Med. 2025;15 (8):. doi: 10.3390\/jpm15080340<\/a>. PubMed PMID:40863403<\/a> PubMed Central PMC12387788<\/a>.<\/li>
  7. Tong, TY, Li, Y, Rexrode, KM, Willett, WC, Sun, Q, Manson, JE et al.<\/i>. Dietary Amino Acids and Risk of Stroke Subtypes: Results from 3 Large Prospective Cohort Studies. J Nutr. 2025;155 (5):1560-1569. doi: 10.1016\/j.tjnut.2025.03.026<\/a>. PubMed PMID:40127732<\/a> PubMed Central PMC12121403<\/a>.<\/li>
  8. Deota, S, Pendergast, JS, Kolthur-Seetharam, U, Esser, KA, Gachon, F, Asher, G et al.<\/i>. The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research. Nat Metab. 2025;7 (3):454-468. doi: 10.1038\/s42255-025-01237-6<\/a>. PubMed PMID:40097742<\/a> PubMed Central PMC12584160<\/a>.<\/li>
  9. Micarelli, A, Mrakic-Sposta, S, Vezzoli, A, Malacrida, S, Caputo, S, Micarelli, B et al.<\/i>. Chemosensory and cardiometabolic improvements after a fasting-mimicking diet: A randomized cross-over clinical trial. Cell Rep Med. 2025;6 (2):101971. doi: 10.1016\/j.xcrm.2025.101971<\/a>. PubMed PMID:39970875<\/a> PubMed Central PMC11866515<\/a>.<\/li>
  10. Longo, VD. Intermittent and periodic fasting in the treatment of obesity and type 2 diabetes mellitus. Nat Rev Endocrinol. 2025;21 (2):73-74. doi: 10.1038\/s41574-024-01078-5<\/a>. PubMed PMID:39672887<\/a> .<\/li>
  11. Brandhorst, S, Longo, VD. Fasting-mimicking diet potentiates anti-tumor effects of CDK4\/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling. Drug Resist Updat. 2025;78 :101182. doi: 10.1016\/j.drup.2024.101182<\/a>. PubMed PMID:39665873<\/a> .<\/li>
  12. Villani, V, Frank, CN, Cravedi, P, Hou, X, Bin, S, Kamitakahara, A et al.<\/i>. A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy. Sci Transl Med. 2024;16 (771):eadl5514. doi: 10.1126\/scitranslmed.adl5514<\/a>. PubMed PMID:39475573<\/a> .<\/li>
  13. Lyu, YX, Fu, Q, Wilczok, D, Ying, K, King, A, Antebi, A et al.<\/i>. Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity. Aging (Albany NY). 2024;16 (20):12955-12976. doi: 10.18632\/aging.206135<\/a>. PubMed PMID:39418098<\/a> PubMed Central PMC11552646<\/a>.<\/li>
  14. Warken, AJ, Kubeneck, S, Camargo, AF, Longo, VD, Romani, LC, Klein, GH et al.<\/i>. Production and concentration of keratinases and application of fermentation residual in removing hexavalent chromium. Bioprocess Biosyst Eng. 2024;47 (12):2091-2099. doi: 10.1007\/s00449-024-03087-0<\/a>. PubMed PMID:39271537<\/a> .<\/li>
  15. Fanti, M, Longo, VD. Nutrition, GH\/IGF-1 signaling, and cancer. Endocr Relat Cancer. 2024;31 (11):. doi: 10.1530\/ERC-23-0048<\/a>. PubMed PMID:39166749<\/a> PubMed Central PMC11771996<\/a>.<\/li>
  16. Koppold, DA, Breinlinger, C, Hanslian, E, Kessler, C, Cramer, H, Khokhar, AR et al.<\/i>. International consensus on fasting terminology. Cell Metab. 2024;36 (8):1779-1794.e4. doi: 10.1016\/j.cmet.2024.06.013<\/a>. PubMed PMID:39059384<\/a> PubMed Central PMC11504329<\/a>.<\/li>
  17. Vernieri, C, Ligorio, F, Tripathy, D, Longo, VD. Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence. Cell Metab. 2024;36 (8):1644-1667. doi: 10.1016\/j.cmet.2024.06.014<\/a>. PubMed PMID:39059383<\/a> .<\/li>
  18. Guevara-Aguirre, J, Mishra, A, Canepa, M, Guevara, C, Villacres, \u00c1, Guevara, A et al.<\/i>. Normal or improved cardiovascular risk factors in IGF-I-deficient adults with growth hormone receptor deficiency. Med. 2024;5 (7):816-825.e4. doi: 10.1016\/j.medj.2024.03.022<\/a>. PubMed PMID:38677286<\/a> PubMed Central PMC11246805<\/a>.<\/li>
  19. Brandhorst, S, Longo, VD. Exploring juventology: unlocking the secrets of youthspan and longevity programs. Front Aging. 2024;5 :1379289. doi: 10.3389\/fragi.2024.1379289<\/a>. PubMed PMID:38638872<\/a> PubMed Central PMC11024265<\/a>.<\/li>
  20. van den Burg, EL, Schoonakker, MP, van Peet, PG, van den Akker-van Marle, EM, Lamb, HJ, Longo, VD et al.<\/i>. Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial. Diabetologia. 2024;67 (7):1245-1259. doi: 10.1007\/s00125-024-06137-0<\/a>. PubMed PMID:38546821<\/a> PubMed Central PMC11153305<\/a>.<\/li>
  21. Sanches, FL, Weis, CMSC, Gon\u00e7alves, GCV, Andrade, GS, Diniz, LGT, Camargo, AF et al.<\/i>. Study and characterization of a product based on a vegetable extract of quinoa fermented with water kefir grains. World J Microbiol Biotechnol. 2024;40 (4):118. doi: 10.1007\/s11274-024-03943-x<\/a>. PubMed PMID:38429465<\/a> .<\/li>
  22. Brandhorst, S, Levine, ME, Wei, M, Shelehchi, M, Morgan, TE, Nayak, KS et al.<\/i>. Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nat Commun. 2024;15 (1):1309. doi: 10.1038\/s41467-024-45260-9<\/a>. PubMed PMID:38378685<\/a> PubMed Central PMC10879164<\/a>.<\/li>
  23. Raucci, F, Vernieri, C, Di Tano, M, Ligorio, F, Bla\u017eevit\u0161, O, Lazzeri, S et al.<\/i>. Cyclic Fasting-Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia. Cancer Res. 2024;84 (7):1133-1148. doi: 10.1158\/0008-5472.CAN-23-0295<\/a>. PubMed PMID:38241703<\/a> PubMed Central PMC10982641<\/a>.<\/li>
  24. Giuliani, G, Longo, VD. Ketone bodies in cell physiology and cancer. Am J Physiol Cell Physiol. 2024;326 (3):C948-C963. doi: 10.1152\/ajpcell.00441.2023<\/a>. PubMed PMID:38189128<\/a> .<\/li>
  25. Mirisola, MG, Longo, VD. Inactivation of Ymr1, Sjl2\/3 phosphatases promotes stress resistance and longevity in wild type and Ras2G19V yeast. Biomed J. 2024;47 (2):100694. doi: 10.1016\/j.bj.2023.100694<\/a>. PubMed PMID:38154617<\/a> PubMed Central PMC10950826<\/a>.<\/li>
  26. Mishra, A, Giuliani, G, Longo, VD. Nutrition and dietary restrictions in cancer prevention. Biochim Biophys Acta Rev Cancer. 2024;1879 (1):189063. doi: 10.1016\/j.bbcan.2023.189063<\/a>. PubMed PMID:38147966<\/a> .<\/li>
  27. Buono, R, Tucci, J, Cutri, R, Guidi, N, Mangul, S, Raucci, F et al.<\/i>. Fasting-Mimicking Diet Inhibits Autophagy and Synergizes with Chemotherapy to Promote T-Cell-Dependent Leukemia-Free Survival. Cancers (Basel). 2023;15 (24):. doi: 10.3390\/cancers15245870<\/a>. PubMed PMID:38136414<\/a> PubMed Central PMC10741737<\/a>.<\/li>
  28. Mishra, A, Fanti, M, Ge, X, Vaughn, D, Brandhorst, S, Wei, M et al.<\/i>. Fasting mimicking diet cycles versus a Mediterranean diet and cardiometabolic risk in overweight and obese hypertensive subjects: a randomized clinical trial. NPJ Metab Health Dis. 2023;1 (1):1. doi: 10.1038\/s44324-023-00002-1<\/a>. PubMed PMID:40604264<\/a> PubMed Central PMC12118742<\/a>.<\/li>
  29. Cortellino, S, Quagliariello, V, Delfanti, G, Bla\u017eevit\u0161, O, Chiodoni, C, Maurea, N et al.<\/i>. Fasting mimicking diet in mice delays cancer growth and reduces immunotherapy-associated cardiovascular and systemic side effects. Nat Commun. 2023;14 (1):5529. doi: 10.1038\/s41467-023-41066-3<\/a>. PubMed PMID:37684243<\/a> PubMed Central PMC10491752<\/a>.<\/li>
  30. Cortellino, S, Longo, VD. Metabolites and Immune Response in Tumor Microenvironments. Cancers (Basel). 2023;15 (15):. doi: 10.3390\/cancers15153898<\/a>. PubMed PMID:37568713<\/a> PubMed Central PMC10417674<\/a>.<\/li>
  31. Kender, Z, von Rauchhaupt, E, Schwarz, D, Tsilingiris, D, Schimpfle, L, Bartl, H et al.<\/i>. Six-month periodic fasting does not affect somatosensory nerve function in type 2 diabetes patients. Front Endocrinol (Lausanne). 2023;14 :1143799. doi: 10.3389\/fendo.2023.1143799<\/a>. PubMed PMID:37251671<\/a> PubMed Central PMC10213657<\/a>.<\/li>
  32. Bla\u017eevit\u0161, O, Di Tano, M, Longo, VD. Fasting and fasting mimicking diets in cancer prevention and therapy. Trends Cancer. 2023;9 (3):212-222. doi: 10.1016\/j.trecan.2022.12.006<\/a>. PubMed PMID:36646607<\/a> .<\/li>
  33. Maragkakis, M, Malla, S, Hatzoglou, M, Trifunovic, A, Glick, AB, Finkel, T et al.<\/i>. Biology of Stress Responses in Aging. Aging Biol. 2023;1 :. doi: 10.59368\/agingbio.20230001<\/a>. PubMed PMID:38500537<\/a> PubMed Central PMC10947073<\/a>.<\/li>
  34. Lobo, F, Haase, J, Brandhorst, S. The Effects of Dietary Interventions on Brain Aging and Neurological Diseases. Nutrients. 2022;14 (23):. doi: 10.3390\/nu14235086<\/a>. PubMed PMID:36501116<\/a> PubMed Central PMC9740746<\/a>.<\/li>
  35. Di Tano, M, Longo, VD. Fasting and cancer: from yeast to mammals. Int Rev Cell Mol Biol. 2022;373 :81-106. doi: 10.1016\/bs.ircmb.2022.02.005<\/a>. PubMed PMID:36283768<\/a> .<\/li>
  36. Brandhorst, S, Clark, DL. Food security for survivors of intimate partner violence: Understanding the role of food in survivor well-being. Health Soc Care Community. 2022;30 (6):e6267-e6275. doi: 10.1111\/hsc.14064<\/a>. PubMed PMID:36251587<\/a> PubMed Central PMC10092206<\/a>.<\/li>
  37. Brandhorst, S, Longo, VD. Breakfast keeps hunger in check. Cell Metab. 2022;34 (10):1420-1421. doi: 10.1016\/j.cmet.2022.09.015<\/a>. PubMed PMID:36198286<\/a> .<\/li>
  38. Rangan, P, Lobo, F, Parrella, E, Rochette, N, Morselli, M, Stephen, TL et al.<\/i>. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell Rep. 2022;40 (13):111417. doi: 10.1016\/j.celrep.2022.111417<\/a>. PubMed PMID:36170815<\/a> PubMed Central PMC9648488<\/a>.<\/li>
  39. Cortellino, S, Raveane, A, Chiodoni, C, Delfanti, G, Pisati, F, Spagnolo, V et al.<\/i>. Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects. Cell Rep. 2022;40 (8):111256. doi: 10.1016\/j.celrep.2022.111256<\/a>. PubMed PMID:36001966<\/a> .<\/li>
  40. Mishra, A, Longo, VD. Fasting and Fasting Mimicking Diets in Obesity and Cardiometabolic Disease Prevention and Treatment. Phys Med Rehabil Clin N Am. 2022;33 (3):699-717. doi: 10.1016\/j.pmr.2022.04.009<\/a>. PubMed PMID:35989059<\/a> .<\/li>
  41. Gregor, A, Huber, L, Auernigg-Haselmaier, S, Sternberg, F, Billerhart, M, Dunkel, A et al.<\/i>. A Comparison of the Impact of Restrictive Diets on the Gastrointestinal Tract of Mice. Nutrients. 2022;14 (15):. doi: 10.3390\/nu14153120<\/a>. PubMed PMID:35956298<\/a> PubMed Central PMC9370610<\/a>.<\/li>
  42. Mirisola, MG, Longo, VD. Yeast Chronological Lifespan: Longevity Regulatory Genes and Mechanisms. Cells. 2022;11 (10):. doi: 10.3390\/cells11101714<\/a>. PubMed PMID:35626750<\/a> PubMed Central PMC9139625<\/a>.<\/li>
  43. Fay-Watt, V, O'Connor, S, Roshan, D, Romeo, AC, Longo, VD, Sullivan, FJ et al.<\/i>. Correction: The impact of a fasting mimicking diet on the metabolic health of a prospective cohort of patients with prostate cancer: a pilot implementation study. Prostate Cancer Prostatic Dis. 2023;26 (2):435. doi: 10.1038\/s41391-022-00540-7<\/a>. PubMed PMID:35585259<\/a> PubMed Central PMC10247363<\/a>.<\/li>
  44. Longo, VD, Anderson, RM. Nutrition, longevity and disease: From molecular mechanisms to interventions. Cell. 2022;185 (9):1455-1470. doi: 10.1016\/j.cell.2022.04.002<\/a>. PubMed PMID:35487190<\/a> PubMed Central PMC9089818<\/a>.<\/li>
  45. Fay-Watt, V, O'Connor, S, Roshan, D, Romeo, AC, Longo, VD, Sullivan, FJ et al.<\/i>. The impact of a fasting mimicking diet on the metabolic health of a prospective cohort of patients with prostate cancer: a pilot implementation study. Prostate Cancer Prostatic Dis. 2023;26 (2):317-322. doi: 10.1038\/s41391-022-00528-3<\/a>. PubMed PMID:35314788<\/a> PubMed Central PMC10247368<\/a>.<\/li>
  46. Rahmani, J, Montesanto, A, Giovannucci, E, Zand, H, Barati, M, Kopchick, JJ et al.<\/i>. Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Aging Cell. 2022;21 (2):e13540. doi: 10.1111\/acel.13540<\/a>. PubMed PMID:35048526<\/a> PubMed Central PMC8844108<\/a>.<\/li>
  47. Nardon, M, Venturelli, M, Ruzzante, F, Longo, VD, Bertucco, M. Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial. Eur J Appl Physiol. 2022;122 (3):651-661. doi: 10.1007\/s00421-021-04867-2<\/a>. PubMed PMID:35034194<\/a> .<\/li>
  48. Canali, I, Rosito, LPS, Longo, VD, Costa, SSD. Critical analysis of moderate and severe retractions in the pars tensa and pars flaccida of the tympanic membrane. Braz J Otorhinolaryngol. 2023;89 (1):114-121. doi: 10.1016\/j.bjorl.2021.10.005<\/a>. PubMed PMID:34896036<\/a> PubMed Central PMC9874355<\/a>.<\/li>
  49. Vernieri, C, Fuc\u00e0, G, Ligorio, F, Huber, V, Vingiani, A, Iannelli, F et al.<\/i>. Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer. Cancer Discov. 2022;12 (1):90-107. doi: 10.1158\/2159-8290.CD-21-0030<\/a>. PubMed PMID:34789537<\/a> PubMed Central PMC9762338<\/a>.<\/li>
  50. Diaz-Ruiz, A, Rhinesmith, T, Pomatto-Watson, LCD, Price, NL, Eshaghi, F, Ehrlich, MR et al.<\/i>. Diet composition influences the metabolic benefits of short cycles of very low caloric intake. Nat Commun. 2021;12 (1):6463. doi: 10.1038\/s41467-021-26654-5<\/a>. PubMed PMID:34753921<\/a> PubMed Central PMC8578605<\/a>.<\/ol>Search PubMed<\/a>[\/vc_column_text][vc_btn title=”View Publications on PubMed” style=”custom” custom_background=”#990000″ custom_text=”#FFFFFF” shape=”square” size=”lg” css=”” link=”url:https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F%3Fterm%3D%2528Longo%2BVD%2529%2BOR%2B%2528Brandhorst%2BS%2529%26sort%3Drelevance|target:_blank”][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

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