{"id":348,"date":"2018-08-09T15:52:51","date_gmt":"2018-08-09T15:52:51","guid":{"rendered":"http:\/\/gero.usc.edu\/labs\/matherlab\/?p=348"},"modified":"2018-08-09T16:19:05","modified_gmt":"2018-08-09T16:19:05","slug":"new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/","title":{"rendered":"New project examines the locus coeruleus and memory selectivity in Alzheimer’s disease"},"content":{"rendered":"

Sara Gallant received a two-year postdoctoral fellowship from the BrightFocus Foundation to examine the effects of emotional arousal on attention and memory selectivity during aging and late-onset Alzheimer\u2019s disease. The project will focus on the locus coeruleus (LC), which helps the brain to selectively focus on important information and ignore distraction when we\u2019re alarmed or excited (Lee et al., 2018). Using a combination of behavioral, neuroimaging, and psychophysiological approaches, we will examine how the LC\u2019s ability to facilitate cognitive selectivity changes with age and as a result of Alzheimer\u2019s disease. This is an important question to address in light of recent evidence that the LC is one of the first brain regions to exhibit tau pathology, a hallmark of Alzheimer\u2019s disease (Braak et al., 2011).<\/p>\n

Read more about the project here: https:\/\/www.brightfocus.org\/alzheimers\/grant\/locus-coeruleus-and-memory-selectivity-aging-and-alzheimers-disease<\/a><\/p>\n

Braak, H., Thal, D. R., Ghebremedhin, E., & Del Tredici, K. (2011). Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. Journal of Neuropathology and Experimental Neurology, 70, 960-969.<\/p>\n

Lee, T. H., Greening, S. G., Ueno, T., Clewett, D., Ponzio, A., Sakaki, M., & Mather, M. (2018). Arousal increases neural gain via the locus coeruleus-norepinephrine system in younger adults but not in older adults. Nature Human Behavior, 2, 356-366<\/p>\n","protected":false},"excerpt":{"rendered":"

Sara Gallant received a two-year postdoctoral fellowship from the BrightFocus Foundation to examine the effects of emotional arousal on attention and memory selectivity during aging and late-onset Alzheimer\u2019s disease. The project will focus on the locus coeruleus (LC), which helps the brain to selectively focus on important information and ignore distraction when we\u2019re alarmed or […]<\/p>\n","protected":false},"author":12,"featured_media":361,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,5,4,6,11],"tags":[],"class_list":["post-348","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-all","category-alzheimers-disease","category-brain-and-aging","category-locus-coeruleus","category-research"],"acf":[],"yoast_head":"\nNew project examines the locus coeruleus and memory selectivity in Alzheimer's disease - Emotion & Cognition Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New project examines the locus coeruleus and memory selectivity in Alzheimer's disease - Emotion & Cognition Lab\" \/>\n<meta property=\"og:description\" content=\"Sara Gallant received a two-year postdoctoral fellowship from the BrightFocus Foundation to examine the effects of emotional arousal on attention and memory selectivity during aging and late-onset Alzheimer\u2019s disease. The project will focus on the locus coeruleus (LC), which helps the brain to selectively focus on important information and ignore distraction when we\u2019re alarmed or […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Emotion & Cognition Lab\" \/>\n<meta property=\"article:published_time\" content=\"2018-08-09T15:52:51+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-08-09T16:19:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/gero.usc.edu\/labs\/matherlab\/files\/2018\/08\/stockvault-artificial-intelligence-concept-robotic-brain197026_stockvault.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2550\" \/>\n\t<meta property=\"og:image:height\" content=\"1610\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/2018\\\/08\\\/09\\\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/2018\\\/08\\\/09\\\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\\\/\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"New project examines the locus coeruleus and memory selectivity in Alzheimer’s disease\",\"datePublished\":\"2018-08-09T15:52:51+00:00\",\"dateModified\":\"2018-08-09T16:19:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/2018\\\/08\\\/09\\\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\\\/\"},\"wordCount\":223,\"image\":{\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/2018\\\/08\\\/09\\\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/files\\\/2018\\\/08\\\/stockvault-artificial-intelligence-concept-robotic-brain197026_stockvault.jpg\",\"articleSection\":[\"All\",\"Alzheimer's Disease\",\"Brain and Aging\",\"Locus coeruleus\",\"Research\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/2018\\\/08\\\/09\\\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\\\/\",\"url\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/2018\\\/08\\\/09\\\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\\\/\",\"name\":\"New project examines the locus coeruleus and memory selectivity in Alzheimer's disease - Emotion & Cognition Lab\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/2018\\\/08\\\/09\\\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/2018\\\/08\\\/09\\\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/files\\\/2018\\\/08\\\/stockvault-artificial-intelligence-concept-robotic-brain197026_stockvault.jpg\",\"datePublished\":\"2018-08-09T15:52:51+00:00\",\"dateModified\":\"2018-08-09T16:19:05+00:00\",\"author\":{\"@id\":\"\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/2018\\\/08\\\/09\\\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/2018\\\/08\\\/09\\\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/2018\\\/08\\\/09\\\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\\\/#primaryimage\",\"url\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/files\\\/2018\\\/08\\\/stockvault-artificial-intelligence-concept-robotic-brain197026_stockvault.jpg\",\"contentUrl\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/files\\\/2018\\\/08\\\/stockvault-artificial-intelligence-concept-robotic-brain197026_stockvault.jpg\",\"width\":2550,\"height\":1610,\"caption\":\"Artificial Intelligence Concept - Robotic Brain\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/2018\\\/08\\\/09\\\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"New project examines the locus coeruleus and memory selectivity in Alzheimer’s disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/#website\",\"url\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/\",\"name\":\"Emotion & Cognition Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"\",\"url\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/matherlab\\\/author\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"New project examines the locus coeruleus and memory selectivity in Alzheimer's disease - Emotion & Cognition Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/","og_locale":"en_US","og_type":"article","og_title":"New project examines the locus coeruleus and memory selectivity in Alzheimer's disease - Emotion & Cognition Lab","og_description":"Sara Gallant received a two-year postdoctoral fellowship from the BrightFocus Foundation to examine the effects of emotional arousal on attention and memory selectivity during aging and late-onset Alzheimer\u2019s disease. The project will focus on the locus coeruleus (LC), which helps the brain to selectively focus on important information and ignore distraction when we\u2019re alarmed or […]","og_url":"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/","og_site_name":"Emotion & Cognition Lab","article_published_time":"2018-08-09T15:52:51+00:00","article_modified_time":"2018-08-09T16:19:05+00:00","og_image":[{"width":2550,"height":1610,"url":"https:\/\/gero.usc.edu\/labs\/matherlab\/files\/2018\/08\/stockvault-artificial-intelligence-concept-robotic-brain197026_stockvault.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Written by":"","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/#article","isPartOf":{"@id":"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/"},"author":{"name":"","@id":""},"headline":"New project examines the locus coeruleus and memory selectivity in Alzheimer’s disease","datePublished":"2018-08-09T15:52:51+00:00","dateModified":"2018-08-09T16:19:05+00:00","mainEntityOfPage":{"@id":"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/"},"wordCount":223,"image":{"@id":"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/gero.usc.edu\/labs\/matherlab\/files\/2018\/08\/stockvault-artificial-intelligence-concept-robotic-brain197026_stockvault.jpg","articleSection":["All","Alzheimer's Disease","Brain and Aging","Locus coeruleus","Research"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/","url":"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/","name":"New project examines the locus coeruleus and memory selectivity in Alzheimer's disease - Emotion & Cognition Lab","isPartOf":{"@id":"https:\/\/gero.usc.edu\/labs\/matherlab\/#website"},"primaryImageOfPage":{"@id":"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/#primaryimage"},"image":{"@id":"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/gero.usc.edu\/labs\/matherlab\/files\/2018\/08\/stockvault-artificial-intelligence-concept-robotic-brain197026_stockvault.jpg","datePublished":"2018-08-09T15:52:51+00:00","dateModified":"2018-08-09T16:19:05+00:00","author":{"@id":""},"breadcrumb":{"@id":"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/#primaryimage","url":"https:\/\/gero.usc.edu\/labs\/matherlab\/files\/2018\/08\/stockvault-artificial-intelligence-concept-robotic-brain197026_stockvault.jpg","contentUrl":"https:\/\/gero.usc.edu\/labs\/matherlab\/files\/2018\/08\/stockvault-artificial-intelligence-concept-robotic-brain197026_stockvault.jpg","width":2550,"height":1610,"caption":"Artificial Intelligence Concept - Robotic Brain"},{"@type":"BreadcrumbList","@id":"https:\/\/gero.usc.edu\/labs\/matherlab\/2018\/08\/09\/new-project-examines-the-locus-coeruleus-and-memory-selectivity-in-alzheimers-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/gero.usc.edu\/labs\/matherlab\/"},{"@type":"ListItem","position":2,"name":"New project examines the locus coeruleus and memory selectivity in Alzheimer’s disease"}]},{"@type":"WebSite","@id":"https:\/\/gero.usc.edu\/labs\/matherlab\/#website","url":"https:\/\/gero.usc.edu\/labs\/matherlab\/","name":"Emotion & Cognition Lab","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/gero.usc.edu\/labs\/matherlab\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"","url":"https:\/\/gero.usc.edu\/labs\/matherlab\/author\/"}]}},"_links":{"self":[{"href":"https:\/\/gero.usc.edu\/labs\/matherlab\/wp-json\/wp\/v2\/posts\/348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gero.usc.edu\/labs\/matherlab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gero.usc.edu\/labs\/matherlab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gero.usc.edu\/labs\/matherlab\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/gero.usc.edu\/labs\/matherlab\/wp-json\/wp\/v2\/comments?post=348"}],"version-history":[{"count":0,"href":"https:\/\/gero.usc.edu\/labs\/matherlab\/wp-json\/wp\/v2\/posts\/348\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gero.usc.edu\/labs\/matherlab\/wp-json\/wp\/v2\/media\/361"}],"wp:attachment":[{"href":"https:\/\/gero.usc.edu\/labs\/matherlab\/wp-json\/wp\/v2\/media?parent=348"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gero.usc.edu\/labs\/matherlab\/wp-json\/wp\/v2\/categories?post=348"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gero.usc.edu\/labs\/matherlab\/wp-json\/wp\/v2\/tags?post=348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}