{"id":6,"date":"2017-12-27T23:06:57","date_gmt":"2017-12-27T23:06:57","guid":{"rendered":"http:\/\/gero.usc.edu\/labs\/pikelab\/?page_id=6"},"modified":"2024-12-16T21:24:43","modified_gmt":"2024-12-16T21:24:43","slug":"the-pike-lab","status":"publish","type":"page","link":"https:\/\/gero.usc.edu\/labs\/pikelab\/","title":{"rendered":"The Pike Lab"},"content":{"rendered":"

[vc_row][vc_column][vc_single_image image=”199″ img_size=”1800X350″ alignment=”center” css=”.vc_custom_1571969061812{padding-bottom: 25px !important;}”][vc_column_text el_class=”intro-text”]Research in the Pike Lab is broadly focused on Alzheimer\u2019s disease (AD), with the general goals of elucidating factors that regulate AD pathogenesis and pursuing translational strategies for the prevention and treatment of the disease. Our approach to investigating research questions involves the use of complementary cellular, biochemical and molecular techniques to analyze relationships in human tissues, non-transgenic and transgenic rodent models, and cultured cells. Current areas of research focus in the Pike Lab include the role of obesity in AD risk, the contributions of the genetic risk factor APOE4 to AD pathogenesis, sex differences in AD, the relationships between age-related losses of steroid hormones and the development of AD, and interactions among these areas. We seek to identify and elucidate the mechanisms underlying AD risks and use this information to develop therapeutic interventions.[\/vc_column_text][vc_empty_space height=”15px”][vc_separator][\/vc_column][\/vc_row][vc_section][vc_row][vc_column][vc_column_text]<\/p>\n

Focus Areas<\/h3>\n

[\/vc_column_text][vc_row_inner content_placement=”middle”][vc_column_inner width=”1\/3″][vc_icon icon_fontawesome=”fa fa-users” color=”white” background_style=”rounded” background_color=”custom” size=”lg” align=”center” custom_background_color=”#1d244c” link=”url:https%3A%2F%2Fgero.usc.edu%2Flabs%2Fpikelab%2Fresearch%2F%23research-testosterone|||” el_class=”focus-areas-icons”][vc_column_text el_class=”focus-areas-links”]<\/p>\n

Sex differences in Alzheimer’s Disease risk associated with APOE4<\/strong><\/a><\/p>\n

[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_icon icon_fontawesome=”fa fa-female” color=”white” background_style=”rounded” background_color=”custom” size=”lg” align=”center” custom_background_color=”#1d244c” link=”url:https%3A%2F%2Fgero.usc.edu%2Flabs%2Fpikelab%2Fresearch%2F%23research-menopause|||” el_class=”focus-areas-icons”][vc_column_text el_class=”focus-areas-links”]<\/p>\n

Protective diets as prevention and\u00a0treatment strategies against APOE4 and Alzheimer\u2019s disease<\/a><\/strong><\/p>\n

[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/3″][vc_icon icon_fontawesome=”fas fa-exchange-alt” color=”white” background_style=”rounded” background_color=”custom” size=”lg” align=”center” custom_background_color=”#1d244c” link=”url:https%3A%2F%2Fgero.usc.edu%2Flabs%2Fpikelab%2Fresearch%2F%23research-trans|||” el_class=”focus-areas-icons”][vc_column_text el_class=”focus-areas-links”]<\/p>\n

Longevity-promoting\u00a0compounds as protectants\u00a0against APOE4 and Alzheimer’s disease<\/strong><\/a><\/p>\n

[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_empty_space][vc_separator][vc_empty_space][\/vc_column][\/vc_row][vc_row gap=”30″][vc_column width=”1\/2″ css=”.vc_custom_1734117293896{padding-top: 15px !important;padding-right: 15px !important;padding-bottom: 15px !important;padding-left: 15px !important;}”][vc_column_text]<\/p>\n

Lab Updates<\/h3>\n

[\/vc_column_text][vc_posts_slider count=”5″ interval=”3″ slides_content=”teaser” slides_title=”1″ thumb_size=”full” css=”” posttypes=”post” categories=”lab-update”][vc_btn title=”View more” style=”custom” custom_background=”#990000″ custom_text=”#FFFFFF” align=”center” css=”” link=”url:https%3A%2F%2Fgero.usc.edu%2Flabs%2Fpikelab%2Fnews%2F%23updates”][\/vc_column][vc_column width=”1\/2″][vc_column_text]<\/p>\n

In the News<\/h3>\n

[\/vc_column_text][vc_column_text css=””]