{"id":2,"date":"2018-09-25T21:30:25","date_gmt":"2018-09-25T21:30:25","guid":{"rendered":"http:\/\/gero.usc.edu\/labs\/vermulstlab\/?page_id=2"},"modified":"2019-07-09T00:14:40","modified_gmt":"2019-07-09T00:14:40","slug":"sample-page","status":"publish","type":"page","link":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/","title":{"rendered":"The Vermulst Lab"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1561717541739{padding-bottom: 30px !important;}&#8221;]<div id=\"metaslider-id-34\" style=\"max-width: 1800px;\" class=\"ml-slider-3-109-0 metaslider metaslider-flex metaslider-34 ml-slider has-dots-nav ms-theme-default\" role=\"region\" aria-label=\"Home Slider\" data-height=\"750\" data-width=\"1800\">\n    <div id=\"metaslider_container_34\">\n        <div id=\"metaslider_34\">\n            <ul class='slides'>\n                <li style=\"display: block; width: 100%;\" class=\"slide-45 ms-image \" aria-roledescription=\"slide\" data-date=\"2019-06-28 09:31:00\" data-filename=\"GER1906-sdk-3473-e1775857490128-1050x437.jpg\" data-slide-type=\"image\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/gero.usc.edu\/labs\/vermulstlab\/files\/2019\/06\/GER1906-sdk-3473-e1775857490128-1050x437.jpg\" height=\"750\" width=\"1800\" alt=\"Photograph of Vermulst lab member working in the lab\" class=\"slider-34 slide-45 msDefaultImage\" title=\"GER1906-sdk-3473\" \/><div class=\"caption-wrap\"><div class=\"caption\"><div><a href=\"publications\">Read our research<\/a> Our lab uses multiple models to study the aging process, including yeast, worms, flies, mice and human cell lines.<\/div><\/div><\/div><\/li>\n                <li style=\"display: none; width: 100%;\" class=\"slide-143 ms-image \" aria-roledescription=\"slide\" data-date=\"2019-07-02 20:20:14\" data-filename=\"protein-edited-1600x666.jpg\" data-slide-type=\"image\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/gero.usc.edu\/labs\/vermulstlab\/files\/2019\/07\/protein-edited-1600x666.jpg\" height=\"750\" width=\"1800\" alt=\"Protein diagram\" class=\"slider-34 slide-143 msDefaultImage\" title=\"protein-edited\" \/><div class=\"caption-wrap\"><div class=\"caption\"><div><a href=\"mitochondrial-protein-heterogeneity\">Mitochondrial protein heterogeneity<\/a> We are developing new methods to study protein heterogeneity in organelles.<\/div><\/div><\/div><\/li>\n                <li style=\"display: none; width: 100%;\" class=\"slide-42 ms-image \" aria-roledescription=\"slide\" data-date=\"2019-06-28 09:31:00\" data-filename=\"GER1906-sdk-3661-1800x750.jpg\" data-slide-type=\"image\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/gero.usc.edu\/labs\/vermulstlab\/files\/2019\/06\/GER1906-sdk-3661-1800x750.jpg\" height=\"750\" width=\"1800\" alt=\"Photograph of Vermulst lab member working in the lab\" class=\"slider-34 slide-42 msDefaultImage\" title=\"GER1906-sdk-3661\" \/><div class=\"caption-wrap\"><div class=\"caption\"><div><a href=\"transcription-errors\">Exploring transcription errors<\/a> Learn about our massively parallel sequencing technology to monitor transcriptional mutagenesis.<\/div><\/div><\/div><\/li>\n                <li style=\"display: none; width: 100%;\" class=\"slide-43 ms-image \" aria-roledescription=\"slide\" data-date=\"2019-06-28 09:31:00\" data-filename=\"GER1906-sdk-3619-1800x750.jpg\" data-slide-type=\"image\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/gero.usc.edu\/labs\/vermulstlab\/files\/2019\/06\/GER1906-sdk-3619-1800x750.jpg\" height=\"750\" width=\"1800\" alt=\"Photograph of Vermulst lab member working in the lab\" class=\"slider-34 slide-43 msDefaultImage\" title=\"GER1906-sdk-3619\" \/><div class=\"caption-wrap\"><div class=\"caption\"><div><a href=\"mitochondrial-mutagenesis\">Mitochondrial mutagenesis<\/a> We study progeroid mice to investigate how mtDNA mutations affect aging.<\/div><\/div><\/div><\/li>\n            <\/ul>\n        <\/div>\n        \n    <\/div>\n<\/div>[\/vc_column_text][vc_column_text]Aging is the primary risk factor for almost every disease endemic to western society. By investigating the molecular mechanisms that drive human aging, we will therefore gain new insight into the mechanistic underpinnings of numerous diseases, including cancer, Alzheimer\u2019s and Parkinson\u2019s disease. We are particularly interested in the contribution of genetic instability to human aging. For example, it has long been known that genetic instability of the mitochondrial genome is associated with human aging. We are actively generating new models in worms and mice to expose the spatio-temporal dynamics of mitochondrial mutagenesis in aging organisms, and determine when and where the mutations that contribute to age-related pathology arise. \u00a0In addition, we are exploiting these experiments to identify targets for the treatment of diseases that are caused by mtDNA instability. We are also interested in the stability of the transcriptome. We recently discovered that errors that occur during transcription accelerate the aggregation of proteins that cause age-related diseases in humans. To build on these findings, we are identifying the molecular mechanisms that give rise to transcription errors and linking them to the etiology of Alzheimer\u2019s disease, ALS and Huntington\u2019s disease. Finally, we have developed a new interest in mitochondrial proteomics, and are generating new models to determine how mitochondria maintain their proteome with age.[\/vc_column_text][vc_separator][vc_empty_space height=&#8221;15px&#8221;][\/vc_column][\/vc_row][vc_row][vc_column width=&#8221;1\/2&#8243;][vc_row_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;104&#8243; img_size=&#8221;150X150&#8243; alignment=&#8221;center&#8221; onclick=&#8221;custom_link&#8221; img_link_target=&#8221;_blank&#8221; link=&#8221;https:\/\/gero.usc.edu\/faculty\/marc-vermulst-phd\/&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;2\/3&#8243;][vc_column_text]<\/p>\n<h3><a href=\"https:\/\/gero.usc.edu\/faculty\/marc-vermulst-phd\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Marc Vermulst, PhD<\/strong><\/a><\/h3>\n<p>[\/vc_column_text][vc_column_text el_id=&#8221;pi-contact-info&#8221;]<strong>Assistant Professor of Gerontology<\/strong><br \/>\n<strong>Email:<\/strong> vermulst@usc.edu[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_column_text]<\/p>\n<h3>Primary Research Areas<\/h3>\n<ul>\n<li><a href=\"https:\/\/gero.usc.edu\/labs\/vermulstlab\/mitochondrial-mutagenesis\/\">Mitochondrial mutagenesis<\/a><\/li>\n<li><a href=\"https:\/\/gero.usc.edu\/labs\/vermulstlab\/transcription-errors\/\">Transcription errors<\/a><\/li>\n<li><a href=\"https:\/\/gero.usc.edu\/labs\/vermulstlab\/mitochondrial-protein-heterogeneity\/\">Mitochondrial protein heterogeneity<\/a><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_section][\/vc_section]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1561717541739{padding-bottom: 30px !important;}&#8221;][\/vc_column_text][vc_column_text]Aging is the primary risk factor for almost every disease endemic to western society. By investigating the molecular mechanisms that drive human aging, we will therefore gain new insight into the mechanistic underpinnings of numerous diseases, including cancer, Alzheimer\u2019s and Parkinson\u2019s disease. We are particularly interested in the contribution of genetic instability [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"page-full.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Vermulst Lab - The Vermulst Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gero.usc.edu\/labs\/vermulstlab\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Vermulst Lab - The Vermulst Lab\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1561717541739{padding-bottom: 30px !important;}&#8221;][\/vc_column_text][vc_column_text]Aging is the primary risk factor for almost every disease endemic to western society. By investigating the molecular mechanisms that drive human aging, we will therefore gain new insight into the mechanistic underpinnings of numerous diseases, including cancer, Alzheimer\u2019s and Parkinson\u2019s disease. 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