{"id":68,"date":"2019-06-28T17:45:05","date_gmt":"2019-06-28T17:45:05","guid":{"rendered":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/?page_id=68"},"modified":"2025-10-29T03:35:50","modified_gmt":"2025-10-29T03:35:50","slug":"publications","status":"publish","type":"page","link":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text css=””]Shemtov SJ, McGann E, Carrillo L, Lee S, Anson H, Chung CS, Anagnostou ME, Lai GD, Verheijen BM, Wan J, Vorobyova I, Sanchez-Contreras M, Conover CA, Thorwald MA, Cohen P, Kennedy SR, Gout JF, Haroon S, Vermulst M. The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome<\/a>.<\/strong> bioRxiv [Preprint]. 2025 Jun 6. doi: 10.1101\/2025.06.03.656903. PMID: 40501628<\/p>\n

Symons J, Chung C, Verheijen BM, Shemtov SJ, de Jong D, Amatngalim G, Nijhuis M, Vermulst M, Gout JF. The mutational landscape of SARS-CoV-2 provides new insight into viral evolution and fitness. <\/strong><\/a><\/span>Nat Commun. 2025 Jul 11;16(1):6425. doi: 10.1038\/s41467-025-61555-x. <\/span>PMID: 40645940<\/span><\/span><\/p>\n

Li W, Baehr S, Marasco M, Reyes L, Brister D, Pikaard CS, Gout JF, Vermulst M, Lynch M. A narrow range of transcript-error rates across the Tree of Life.<\/strong> <\/a><\/span>Sci Adv. 2025 Jul 11;11(28):eadv9898. doi: 10.1126\/sciadv.adv9898. <\/span>PMID: 40644547<\/span><\/span><\/p>\n

Thorwald MA, Godoy-Lugo JA, Kerstiens E, Garcia G, Kim M, Shemtov SJ, Silva J, Durra S, O’Day PA, Mack WJ, Hiniker A, Vermulst M, Benayoun BA, Higuchi-Sanabria R, Forman HJ, Head E, Finch CE. Down syndrome with Alzheimer’s disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis.<\/strong> <\/a>Alzheimers Dement. 2025 Jun;21(6):e70322. doi: 10.1002\/alz.70322. PMID: 40536124<\/p>\n

Sun Y, Vermulst M. The hidden costs of imperfection: transcription errors in protein aggregation diseases.<\/strong> <\/a><\/span>Curr Opin Genet Dev. 2025 Aug;93:102350. doi: 10.1016\/j.gde.2025.102350. <\/span>PMID: 40300213<\/span><\/span><\/p>\n

Verheijen BM, Vermulst M. Linking Environmental Genotoxins to Neurodegenerative Diseases Through Transcriptional Mutagenesis. <\/strong><\/a><\/span>Int J Mol Sci. 2024 Oct 24;25(21):11429. doi: 10.3390\/ijms252111429.<\/span>PMID: 39518982<\/span><\/span><\/p>\n

Chung CS*, Kou Y*, Shemtov SJ*, Verheijen BM*<\/strong>, Flores I, Love K, Del Dosso A, Thorwald MA, Liu Y, Hicks D, Sun Y, Toney RG, Carrillo L, Nguyen MM, Biao H, Jin Y, Jauregui AM, Quiroz JD, Head E, Moore DL, Simpson S, Thomas KW, Coba MP, Li Z, Benayoun BA, Rosenthal JJC, Kennedy SR, Quadrato G, Gout JF, Chen L, Vermulst M. Transcript errors generate amyloid-like proteins in human cells.<\/strong> <\/a>Nat Commun. 2024 Oct 7;15(1):8676. doi: 10.1038\/s41467-024-52886-2. PMID: 39375347 *equal contributors<\/strong><\/p>\n

Vermulst M, Paskvan SL, Chung CS, Franke K, Clegg N, Minot S, Madeoy J, Long AS, Gout JF, Bielas JH. MADDD-seq, a novel massively parallel sequencing tool for simultaneous detection of DNA damage and mutations.<\/strong> <\/a>Nucleic Acids Res. 2024 Sep 9;52(16):e76. doi: 10.1093\/nar\/gkae632. PMID: 39149908<\/p>\n

Dinep-Schneider O, Appiah E, Dapper A, Patterson S, Vermulst M, Gout JF. Effects of the glyphosate-based herbicide roundup on C. elegans and S. cerevisiae mortality, reproduction, and transcription fidelity<\/strong><\/a>. Environ Pollut. 2024 Sep 1;356:124203. doi: 10.1016\/j.envpol.2024.124203. PMID: 38830529<\/p>\n

Wang S, Kim K, Gelvez N, Chung C, Gout JF, Fixman B, Vermulst M, Chen XS. Identification of RBM46 as a novel APOBEC1 cofactor for C-to-U RNA-editing activity<\/strong><\/a>. J Mol Biol. 2023 Dec 15;435(24):168333. doi: 10.1016\/j.jmb.2023.168333. PMID: 38708190<\/p>\n

Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Kim J, Torres TC, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, Vega M, Mehta HH, Thorwald MA, Crews P, Vermulst M, Garcia G, Johnson TA, Higuchi-Sanabria R. Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging<\/strong><\/a>. Geroscience. 2024 Dec;46(6):6009-6028. doi: 10.1007\/s11357-024-01144-w. PMID: 38570396<\/p>\n

Verheijen BM, Chung C, Thompson B, Kim H, Nakahara A, Anink JJ, Mills JD; NYGC ALS Consortium; Lee JH, Aronica E, Oyanagi K, Kakita A, Gout JF, Vermulst M.
\nThe cycad genotoxin methylazoxymethanol, linked to Guam ALS\/PDC, induces transcriptional mutagenesis.<\/strong><\/a> Acta Neuropathol Commun. 2024 Feb 21;12(1):30. doi: 10.1186\/s40478-024-01725-y. PMID: 38383591<\/p>\n

Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M. Tau Filaments from Amyotrophic Lateral Sclerosis\/Parkinsonism-Dementia Complex (ALS\/PDC) adopt the CTE Fold<\/strong>.<\/a> PNAS. 2023 Dec 19. doi: 10.1101\/2023.04.26.538417. <\/span>PMID: 37162924<\/span><\/span><\/p>\n

Chung C, Verheijen BM, Zhang X, Huang B, Coakley A, McGann E, Wade E, Dinep-Schneider O, LaGosh J, Anagnostou ME, Simpson S, Thomas K, Ernst M, Rattray A, Lynch M, Kashlev M, Benayoun BA, Li Z, Strathern J, Gout JF, Vermulst M. The fidelity of transcription in human cells.<\/a> <\/strong>PNAS. 2023 Jan 31;120(5):e2210038120. doi: 10.1073\/pnas.2210038120. <\/span><\/p>\n

Chung C, Verheijen BM, Navapanich Z, McGann EG, Shemtov S, Lai GJ, Arora P, Towheed A, Haroon S, Holczbauer A, Chang S, Manojlovic Z, Simpson S, Thomas KW, Kaplan C, van Hasselt P, Timmers M, Erie D, Chen L, Gout JF, Vermulst M. Evolutionary conservation of the fidelity of transcription<\/strong>.<\/a> Nat Commun. 2023 Mar 20;14(1):1547. doi: 10.1038\/s41467-023-36525-w.<\/span><\/p>\n

Fritsch C, Gout JF, Haroon S, Towheed A, Chung C, LaGosh J, McGann E, Zhang X, Song Y, Simpson S, Danthi PS, Benayoun BA, Wallace D, Thomas K, Lynch M, Vermulst M. Genome-wide surveillance of transcription errors in response to genotoxic stress.<\/a> <\/strong>Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2004077118. doi: 10.1073\/pnas.2004077118. PMCID: PMC7817157.<\/p>\n

Haroon S, Vermulst M. Oxygen Consumption Measurements in Caenorhabditis elegans<\/i> Using the Seahorse XF24.<\/a><\/strong> Bio Protoc. 2019 Jul 5;9(13):e3288. doi: 10.21769\/BioProtoc.3288. PMCID: PMC7854111.<\/p>\n

Verheijen BM, Vermulst M, van Leeuwen FW. Somatic mutations in neurons during aging and neurodegeneration.<\/a><\/strong> Acta Neuropathol.<\/em> 2018 Jun;135(6):811-826. doi: 10.1007\/s00401-018-1850-y. Review. | PDF<\/strong><\/a><\/p>\n

C. Fritsch, JF Gout, M. Vermulst. Transcription errors: A new horizon for mutation research. J Vis Exp<\/em>. 2018 Sep 13;(139). doi: 10.3791\/57731<\/p>\n

Meagan J McManus, Hsiao-Wen Chen, Martin Picard, Hans J. De Haas, Prasanth Potluri, Jeremy Leipzig, Atif Towheed, Alessia Angelin, Partho Sengupta, Ryan M. Morrow, Brett A. Kauffman, Marc Vermulst, Jagat Narula, Douglas C. Wallace. Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy.<\/strong><\/a> Cell Metabolism<\/em>, 2019 Jan 8;29(1):78-90.e5. doi: 10.1016\/j.cmet.2018.08.002.<\/p>\n

S. Haroon, A. Li, C. Fritsch, N. Ericson, J. Alexander-Floyd, B.P. Braeckman, C. Haynes, J. Bielas, T. Gidalevitz, M. Vermulst. Multiple molecular mechanisms rescue mtDNA disease in <\/a><\/strong>C. elegans.<\/a><\/strong> Cell Reports, <\/em>Mar 20;22(12):3115-3125. PMID: 29562168 | PDF<\/strong><\/a><\/p>\n

J.-F. Gout, Weiyi Li, C. Fritsch, A. Li, S. Haroon, L. Singh, D. Hua, H. Fazelina, Z. Smith, S, Seeholzer, K. Thomas, M. Lynch, M. Vermulst. The landscape of transcription errors in eukaryotic organisms.<\/a><\/strong> Science Advances<\/em>, published online, October 20th<\/sup> 2017, Vol. 3. No. 10, e1701484. PMID: 29062891 | PDF<\/strong><\/a><\/p>\n

Someya S, Kujoth GC, Kim MJ, Hacker TA, Vermulst M, Weindruch R, Prolla TA. Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice.<\/a><\/strong> PLoS One<\/em>. 2017 Feb 3;12(2):e0171159. doi: 10.1371\/journal.pone.0171159. eCollection 2017. | PDF<\/strong><\/a><\/p>\n

Haroon S, Vermulst M. Linking mitochondrial dynamics to mitochondrial protein quality control.<\/a><\/strong> Curr Opin Genet Dev<\/em>. 2016 Jun;38:68-74. doi: 10.1016\/j.gde.2016.04.004. Review. | PDF<\/a><\/strong><\/p>\n

Vermulst M, Denney AS, Lang MJ, Hung CW, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Cyr D, Kaeberlein M, Strathern JN, Duncan MC and Erie D. Transcription errors induce proteotoxic stress and shorten cellular lifespan.<\/a><\/strong> (Nature Communications<\/em>, 6, article 8065, Aug. 25, 2015) | PDF<\/a><\/strong><\/p>\n

Vermulst M, Khrapko K and Wanagat J. (2012) Mitochondrial mutagenesis in aging and disease.<\/a><\/strong> Book chapter for Mutagenesis,  <\/em>ISBN 978-953-51-0707-1 | PDF<\/a><\/strong><\/p>\n

Ericson N, Kulawiec M, Vermulst M, Sheahan K, O’Sullivan J, Salk J and Bielas JH. (2012) Decreased mitochondrial DNA mutagenesis in human colorectal cancer.<\/a><\/strong> PLoS Genetics <\/em>8, e1002689. doi: 10.1371\/journal.pgen.1002689. PMCID:PMC3369930. | PDF<\/a><\/strong><\/p>\n

Chen HC*, Vermulst M*, <\/strong>Wang YE, Prolla TA, McCaffery MJ and Chan DC. (2010) Mitochondrial fusion is required for mtDNA stability and tolerance of mtDNA mutations.<\/a><\/strong> Cell<\/em> 141, 280\u2010289. PMCID: PMC2858759  * equal contributors | PDF<\/a><\/strong><\/p>\n

Vermulst M, Wanagat J and Loeb LA. (2009) On mitochondria, mutations, and methodology<\/a>.<\/strong> Cell Metabolism<\/em> 10, 437. PMID: 19945399 | PDF<\/a><\/strong><\/p>\n

Dai D, Santana LF, Vermulst M, Tomazeva DM, Emond MJ, Macoss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC and Rabinovitch PS (2009). Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.<\/a> <\/strong>Circulation <\/em>119, 2789-2797. PMCID: PMC2858759 | PDF<\/a><\/strong><\/p>\n

Vermulst M, Bielas, JH and Loeb, LA. (2008) Quantification of mutation in the mitochondrial genome.<\/a> <\/strong>Methods <\/em>46, 263\u2010268. PMCID:PMC2615251 | PDF<\/a><\/strong><\/p>\n

Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA and Loeb LA. (2008) DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice.<\/a> <\/strong>Nature Genetics <\/em>40, 392-394. PMID: 18311139 | PDF<\/a><\/strong><\/p>\n

Vermulst M, Bielas JH, Kujoth GC, Ladiges WG, Rabinovitch PS, Prolla TA and Loeb LA. (2007) Mitochondrial point mutations do not limit the natural lifespan of mice.<\/a> <\/strong>Nature Genetics <\/em>39, 540-543. PMID: 17334366 | PDF<\/strong><\/a><\/p>\n

Associated Commentary: Mitochondrial DNA mutations and aging: a case closed? Konstantin Khrapko and Jan Vijg. (2007) Nature Genetics 39, 445-446.<\/em>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][vc_column_text css=””]Shemtov SJ, McGann E, Carrillo L, Lee S, Anson H, Chung CS, Anagnostou ME, Lai GD, Verheijen BM, Wan J, Vorobyova I, Sanchez-Contreras M, Conover CA, Thorwald MA, Cohen P, Kennedy SR, Gout JF, Haroon S, Vermulst M. The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome. bioRxiv […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-full.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-68","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nPublications - The Vermulst Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gero.usc.edu\/labs\/vermulstlab\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - The Vermulst Lab\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text css=””]Shemtov SJ, McGann E, Carrillo L, Lee S, Anson H, Chung CS, Anagnostou ME, Lai GD, Verheijen BM, Wan J, Vorobyova I, Sanchez-Contreras M, Conover CA, Thorwald MA, Cohen P, Kennedy SR, Gout JF, Haroon S, Vermulst M. The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome. bioRxiv […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/gero.usc.edu\/labs\/vermulstlab\/publications\/\" \/>\n<meta property=\"og:site_name\" content=\"The Vermulst Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-29T03:35:50+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/vermulstlab\\\/publications\\\/\",\"url\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/vermulstlab\\\/publications\\\/\",\"name\":\"Publications - The Vermulst Lab\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/vermulstlab\\\/#website\"},\"datePublished\":\"2019-06-28T17:45:05+00:00\",\"dateModified\":\"2025-10-29T03:35:50+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/vermulstlab\\\/publications\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/vermulstlab\\\/publications\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/vermulstlab\\\/publications\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/vermulstlab\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/vermulstlab\\\/#website\",\"url\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/vermulstlab\\\/\",\"name\":\"The Vermulst Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/gero.usc.edu\\\/labs\\\/vermulstlab\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Publications - The Vermulst Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/publications\/","og_locale":"en_US","og_type":"article","og_title":"Publications - The Vermulst Lab","og_description":"[vc_row][vc_column][vc_column_text css=””]Shemtov SJ, McGann E, Carrillo L, Lee S, Anson H, Chung CS, Anagnostou ME, Lai GD, Verheijen BM, Wan J, Vorobyova I, Sanchez-Contreras M, Conover CA, Thorwald MA, Cohen P, Kennedy SR, Gout JF, Haroon S, Vermulst M. The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome. bioRxiv […]","og_url":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/publications\/","og_site_name":"The Vermulst Lab","article_modified_time":"2025-10-29T03:35:50+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/publications\/","url":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/publications\/","name":"Publications - The Vermulst Lab","isPartOf":{"@id":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/#website"},"datePublished":"2019-06-28T17:45:05+00:00","dateModified":"2025-10-29T03:35:50+00:00","breadcrumb":{"@id":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/publications\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/gero.usc.edu\/labs\/vermulstlab\/publications\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/publications\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/"},{"@type":"ListItem","position":2,"name":"Publications"}]},{"@type":"WebSite","@id":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/#website","url":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/","name":"The Vermulst Lab","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/wp-json\/wp\/v2\/pages\/68","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/wp-json\/wp\/v2\/comments?post=68"}],"version-history":[{"count":3,"href":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/wp-json\/wp\/v2\/pages\/68\/revisions"}],"predecessor-version":[{"id":265,"href":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/wp-json\/wp\/v2\/pages\/68\/revisions\/265"}],"wp:attachment":[{"href":"https:\/\/gero.usc.edu\/labs\/vermulstlab\/wp-json\/wp\/v2\/media?parent=68"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}