About the Curran Lab

Our long-term goal is to generate blueprints that allow an individual to maximize health over the course of their lifespan. Informed by genetics, we develop the capacity to predict which diets are ideal for a healthy life and which should be avoided. Moreover, we investigate the mechanistic basis of the molecules, genes, and pathways we have discovered can influence healthspan. The product of this investment is the ability to use diet as a means to circumvent genetic predisposition and prevent or reduce the severity of age-related disease. Our research has benefited from the ability to quickly test several diet-gene pairs in C. elegans, which has allowed us to transition to directed studies in murine models. Although we will continue to exploit the utility of genetics and biochemistry of the worm, we expect that our mouse and cultured human cell approaches will synergize and provide relevant information for human aging.

Recent Discoveries


Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans

Chia-An Yen, Dana L Ruter, Christian D Turner, Shanshan Pang, Sean P. Curran


Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection.

James D. Nhan, Christian D. Turner, Sarah M. Anderson, Chia-An Yen, Hans M. Dalton, Hilary K. Cheesman, Dana L. Ruter, Nandhitha Uma Naresh, Cole M. Haynes, Alexander A. Soukas, Read Pukkila-Worley, and Sean P. Curran

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Contact us

Lab Phone: (213) 740-9026

Mailing Address:
Curran Lab
University of Southern California
Leonard Davis School of Gerontology
3715 McClintock Ave.
Los Angeles, CA. 90089


We welcome Bennett Van Camp to the Curran Lab for his PhD studies!
Congratulations Amy Hammerquist on successfully defending her dissertation.  Congrats Dr. Hammerquist!
Congratulations Amy Hammerquist on the acceptance of her Bio-protocol manuscript!
Congratulations Amy Hammerquist on the acceptance of her Molecular Biology of the Cell manuscript!
Congratulations Chia-An Yen on the acceptance of her Aging Cell manuscript
Congratulations Amy Hammerquist on the acceptance of her manuscript in Scientific Reports!
Congratulations Nicole Stuhr on the acceptance of her 1st Curran Lab publications in Nature Comms Bio.
Congratulations Chia-An Yen on successfully defending her dissertation.  Congrats Dr. Yen!
Congratulation Nicole Stuhr on receiving a slot on the Chem-Bio  T32 training grant!
Congratulations Amy Hammerquist for submitting her manuscript – BioRxiv
Congratulation Osvaldo Villa for Honorable Mention on his NSF GRFP application!