About the Curran Lab

Our long-term goal is to generate blueprints that allow an individual to maximize health over the course of their lifespan. Informed by genetics, we develop the capacity to predict which diets are ideal for a healthy life and which should be avoided. Moreover, we investigate the mechanistic basis of the molecules, genes, and pathways we have discovered can influence healthspan. The product of this investment is the ability to use diet as a means to circumvent genetic predisposition and prevent or reduce the severity of age-related disease. Our research has benefited from the ability to quickly test several diet-gene pairs in C. elegans, which has allowed us to transition to directed studies in murine models. Although we will continue to exploit the utility of genetics and biochemistry of the worm, we expect that our mouse and cultured human cell approaches will synergize and provide relevant information for human aging.

Recent Discoveries


Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans

Chia-An Yen, Dana L Ruter, Christian D Turner, Shanshan Pang, Sean P. Curran


Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection.

James D. Nhan, Christian D. Turner, Sarah M. Anderson, Chia-An Yen, Hans M. Dalton, Hilary K. Cheesman, Dana L. Ruter, Nandhitha Uma Naresh, Cole M. Haynes, Alexander A. Soukas, Read Pukkila-Worley, and Sean P. Curran


Genetic variation in ALDH4A1 is associated with muscle health over the lifespan and across species

Osvaldo Villa*, Nicole L Stuhr*, Chia-an Yen*, Eileen M Crimmins, Thalida Em Arpawong, Sean P Curran

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Contact us

Lab Phone: (213) 740-9026

Mailing Address:
Curran Lab
University of Southern California
Leonard Davis School of Gerontology
3715 McClintock Ave.
Los Angeles, CA. 90089


Congratulations Nicole Stuhr for receiving an NIH/NIA F31 Research Fellowship!
Congratulations Osvaldo Villa, Nicole Stuhr, and Chia-An Yen on the acceptance of their eLife manuscript!
Welcome to our newest lab technician Matthew Lynn to the Curran lab!
Welcome Carmen Ramos and Brandy Weathers to the Curran Lab for you PhD training!
Welcome our newest lab technicians David Reoyo the Curran lab!
Welcome to the Curran Lab Dr. Ron Irwin!
Congratulations Dr. James Nhan for successfully defending your dissertation!
Welcome Bennett Van Camp to the Curran Lab for his PhD studies!