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Clinical Trials

A Nutritional Intervention for Body, Brain, and Longevity Effects (NIBBLE) 

The study aims to evaluate the safety, feasibility, and efficacy of six-month fasting-mimicking (FMD) intervention in middle-aged adults at elevated risk for Alzheimer’s disease due to the apolipoprotein (APOE) ε4 allele. 

Molecular Transducers of Physical Activity Consortium 

The purpose of this study is to understand how exercise affects the cells and tissues in the body to bring about health benefits. 

Pragmatic Evaluation of events And Benefits of Lipid-lowering in older adults (PREVENTABLE) 

The purpose of this multi-site study is to learn if taking a statin could help older adults live well for longer by preventing dementia, disability or heart disease.  

Repurposing Nucleoside Reverse Transcriptase Inhibitors for Treatment of Alzheimer’s Disease 

The purpose of this study is to determine whether a medication called emtricitabine is safe and tolerable in people with mild to moderate Alzheimer’s disease (AD). 

Single Nuclei RNA-Seq to MAP Adipose Cellular Populations and Senescent Cells in Older Subjects 

The purpose of this study is to evaluate whether senescent cells (cells that age and permanently stop dividing but do not die) affect the body’s ability to metabolize (process sugars).