Publications

Ko S, Yeom E, Chun YL, Mun H, Howard-McGuire M, Millison NT, Jung J, Lee KP, Lee C, Lee KS, Delaney JR, Yoon JH. Profiling of RNA-binding proteins interacting with glucagon and adipokinetic hormone mRNAs. J Lipid Atheroscler, 10:e28 (2021).

Kong BS, Min SH, Lee C*, Cho YM*. Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes. Cell Reports, In Press (2021). *Co-corresponding

Kang GM, Min SH, Lee CH, Kim JY, Lim HS, Jung SB, Park JW, Kim SJ, Park CB, Hong D, Choi JH, Jang WH, Park SE, Cho YM, Kim JG, Kim KG, Choi CS, Kim YB, Lee C*, Shong MH*, Kim MS*. Mitohormesis in hypothalamic POMC neurons mediates regular exercise-induced high-turnover metabolism. Cell Metabolism, In Press (2021).
*Co-corresponding

Reynolds JC, Lai RL, Woodhead J, Joly J, Mitchell CJ, Cameron-Smith D, Cohen P, Lu R, Graham N, Benayoun BA, Merry T, Lee C. Reversal of Age-Dependent Physical Decline by the Exercise-Induced Mitochondrial-Encoded Peptide MOTS-c. Nature Communications, In Press (2021).

Kwon SM, Min SK, Jeoun UW, Sim MS, Jung GH, Jee BA, Woo HG, Lee C, Yoon GS. Global spliceosome activity regulates entry into cellular senescence. FASEB J, In Press (2020)

Merry TL, Chan A, Woodhead JST, Reynolds JC, Kumagai H, Kim SJ, Lee C. Mitochondrial-derived peptides in energy metabolism. Am J Physiol Endocrinol Metab. 319:E659-E666 (2020).

Zempo H, Kim SJ, Fuku N, Nishida Y, Higaki Y, Wan J, Yen K, Miller B, Vicinanza R, Miyamoto-Mikami E, Kumagai H, Naito H, Xiao J, Mehta HH, Lee C, Hara M, Patel YM, Setiawan VW, Moore T, Hevener A, Sutoh Y, Shimizu A, Kojima K, Kinoshita K, Tanaka K, Cohen P. A Pro-Diabetogenic mtDNA Polymorphism in the Mitochondrial-Derived Peptide, MOTS-c. bioRxiv (2019). Under Peer Review (2020).

D’Souza RF, Woodhead JST, Hedges CP, Zeng N, Humagai H, Lee C, Cohen P, Cameron-Smith D, Mitchell CJ, Merry TL. Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition. Aging, In Press (2020).

Chen Y*, Bravo JI*, Son JM, Lee C, Benayoun BA. Remodeling of the H3 nucleosomal landscape during mouse aging. Translational Medicine of Aging 4:22-31 (2020). *Equal Contribution

Reynold JC, Bwiza CP, Lee C. Mitonuclear genomics and aging. Human Genetics 139:381-399 (2020).
Recommended F1000Prime: Osiewacz H, 10.3410/f.737293312.793571684 (2020).

Son JM and Lee C. Mitochondria: multifaceted regulators of aging. BMB Reports 52:13-23 (2019).

Benayoun BA and Lee C. MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus. Bioessays, 41(9):e1900046 (2019).

Lee C. Nuclear Transcriptional Regulation by Mitochondrial-Encoded MOTS-c. Molecular & Cellular Oncology 6:1549464 (2019).

Kim SJ, Chun M, Wan J, Lee C, Yen K, Cohen P. GRSF1 is an age-related regulator of senescence. Scientific Reports 9:5546 (2019).

Kim, KH, Son JM, Benayoun BA, and Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metabolism 28:516-524 (2018).
Covered: A mitochondrial-derived peptide exercises the nuclear option. Cell Metabolism 28:330-331 (2018).
Covered: Going nuclear with stress. Science Signaling 11:eaav4285 (2018).

Lee YK, Lim JJ, Jeoun UW, Min S, Lee EB, Kwon SM, Lee C, Yoon G. Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness. J Biol Chem 292:20208-20217 (2017).

Di Biase S*, Shim HS*, Kim KH*, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Lee C, Longo VD. Fasting Regulates EGR1 and Protects from Glucose-and Dexamethasone Dependent Sensitization to Chemotherapy. PLoS Biology. In Press (2017). * Equal Contribution

Choi IY, Lee C, Longo VD. Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence. Mol Cell Endocrinol. In Press (2017).

Di Biase S*, Lee C*, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan T, Longo VD. Fasting mimicking diet-dependent HO-1 reduction promotes T cell-mediated tumor cytotoxicity. Cancer Cell 30:136-46 (2016). *Equal Contribution

Lee C* and Longo VD*. Growth Hormones and aging. In: Principles of endocrinology and hormone action (Editor: Derek LeRoith and Antonino Belfiore). 2016. (Springer). *Co-corresponding author

Cobb LJ, Lee C, Nakamura HK, Mehta H, Hosono H, Wan J, Gao Q, Ashur C, Muzumdar R, Hwang D, Barzilai N, Cohen P. Naturally Occurring Mitochondrial-Derived Peptides Are Regulators of Physiological Processes. Aging 8:796-809 (2016).

Lee C, Kim K, Cohen P. MOTS-c: a novel mitochondrial-derived peptide regulating muscle metabolism. Free Radic Biol Med. Epub ahead of time (2016).

Lee C* and Longo VD*. Dietary restriction with and without caloric restriction for healthy aging. F1000 Research Review (2016). *Co-corresponding author

Lee C and Longo VD. The Impact of Cancer Treatments on Aging. In: Advances in Geroscience (Editor: Felipe Sierra and Ronald Kohanski; 2015). National Institute on Aging (Springer).

Lee C*, Zeng J, Drew BG, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P*. The Mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism 21: 443-454 (2015). *Co-corresponding author
Covered: A Mitochondrially Encoded Hormone Ameliorates Obesity and Insulin Resistance.
Cell Metabolism 21: 355-356 (2015)

Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo VD, Bartke A, Cohen P. IGF-I Regulates the Age-Dependent Mitochondrial Peptide Humanin. Aging Cell 13:958-961 (2014).

Lee C, Yen K, and Cohen P. Humanin: a harbinger of mitochondrion-derived peptides? Trends in Endocrinology and Metabolism 24:222-8 (2013).

Yen K, Lee C, Mehta H, Cohen P. The emerging role of the mitochondria-derived peptide Humanin in stress resistance. Journal of Molecular Endocrinology 50:1, R11-R19 (2012).

Safdie FM, Brandhorst S, Wei M, Wang W, Lee C, Hwang S, Chen TC, and Longo VD. Fasting Enhances the Response of Glioma to Radio- and Chemotherapy. PLoS One 7:e44603 (2012).

Lee C, Raffaghello L, and Longo VD. Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resistance Updates 15:114-122 (2012).

Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Science translational medicine 4, 124ra127 (2012).
Covered: Impersonalized Medicine. Sci Transl Med 4:124ps6 (2012).
Toxicity in chemotherapy-when less is more. N Engl J Med. 366:2319-20 (2012).

Lee C, and Longo VD. Fasting Dietary Restriction in Cellular Protection and Cancer treatment: from model systems to patients. Oncogene 30:3305-16 (2011).

Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Research 70:1564-72 (2010).

Safdie FM, Dorff T , Quinn D, Fontana L, Wei M, Lee C, Cohen P, Longo VD. Fasting and Cancer Treatment: Ten Case reports. Aging 1:988-1007 (2009).

Wozniak CE, Lee C, and Hughes KT. T-POP array identifies EcnR and PefI-SrgD as novel regulators of flagellar gene expression. Journal of Bacteriology 191:1498-508 (2009).

Raffaghello L*, Lee C*, Safdie FM, Wei M, Madia F, Bianchi G, & Longo VD. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci U S A 105:8215-20 (2008). *Equal Contribution
Covered: Can Fasting Blunt Chemotherapy’s Debilitating Side Effects? Science 29: 1146-1147 (2008).

Lee C, Wozniak C, Karlinsey JE, & Hughes KT. Genomic screening for regulatory genes using the T-POP transposon. Methods in Enzymology 421:159-67 (2007).