Publications

  1. Deota, S, Pendergast, JS, Kolthur-Seetharam, U, Esser, KA, Gachon, F, Asher, G et al.. The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research. Nat Metab. 2025; :. doi: 10.1038/s42255-025-01237-6. PubMed PMID:40097742 .
  2. Micarelli, A, Mrakic-Sposta, S, Vezzoli, A, Malacrida, S, Caputo, S, Micarelli, B et al.. Chemosensory and cardiometabolic improvements after a fasting-mimicking diet: A randomized cross-over clinical trial. Cell Rep Med. 2025;6 (2):101971. doi: 10.1016/j.xcrm.2025.101971. PubMed PMID:39970875 PubMed Central PMC11866515.
  3. Longo, VD. Intermittent and periodic fasting in the treatment of obesity and type 2 diabetes mellitus. Nat Rev Endocrinol. 2025;21 (2):73-74. doi: 10.1038/s41574-024-01078-5. PubMed PMID:39672887 .
  4. Brandhorst, S, Longo, VD. Fasting-mimicking diet potentiates anti-tumor effects of CDK4/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling. Drug Resist Updat. 2025;78 :101182. doi: 10.1016/j.drup.2024.101182. PubMed PMID:39665873 .
  5. Villani, V, Frank, CN, Cravedi, P, Hou, X, Bin, S, Kamitakahara, A et al.. A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy. Sci Transl Med. 2024;16 (771):eadl5514. doi: 10.1126/scitranslmed.adl5514. PubMed PMID:39475573 .
  6. Lyu, YX, Fu, Q, Wilczok, D, Ying, K, King, A, Antebi, A et al.. Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity. Aging (Albany NY). 2024;16 (20):12955-12976. doi: 10.18632/aging.206135. PubMed PMID:39418098 PubMed Central PMC11552646.
  7. Warken, AJ, Kubeneck, S, Camargo, AF, Longo, VD, Romani, LC, Klein, GH et al.. Production and concentration of keratinases and application of fermentation residual in removing hexavalent chromium. Bioprocess Biosyst Eng. 2024;47 (12):2091-2099. doi: 10.1007/s00449-024-03087-0. PubMed PMID:39271537 .
  8. Fanti, M, Longo, VD. Nutrition, GH/IGF-1 signaling, and cancer. Endocr Relat Cancer. 2024;31 (11):. doi: 10.1530/ERC-23-0048. PubMed PMID:39166749 PubMed Central PMC11771996.
  9. Koppold, DA, Breinlinger, C, Hanslian, E, Kessler, C, Cramer, H, Khokhar, AR et al.. International consensus on fasting terminology. Cell Metab. 2024;36 (8):1779-1794.e4. doi: 10.1016/j.cmet.2024.06.013. PubMed PMID:39059384 PubMed Central PMC11504329.
  10. Vernieri, C, Ligorio, F, Tripathy, D, Longo, VD. Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence. Cell Metab. 2024;36 (8):1644-1667. doi: 10.1016/j.cmet.2024.06.014. PubMed PMID:39059383 .
  11. Guevara-Aguirre, J, Mishra, A, Canepa, M, Guevara, C, Villacres, Á, Guevara, A et al.. Normal or improved cardiovascular risk factors in IGF-I-deficient adults with growth hormone receptor deficiency. Med. 2024;5 (7):816-825.e4. doi: 10.1016/j.medj.2024.03.022. PubMed PMID:38677286 PubMed Central PMC11246805.
  12. Brandhorst, S, Longo, VD. Exploring juventology: unlocking the secrets of youthspan and longevity programs. Front Aging. 2024;5 :1379289. doi: 10.3389/fragi.2024.1379289. PubMed PMID:38638872 PubMed Central PMC11024265.
  13. van den Burg, EL, Schoonakker, MP, van Peet, PG, van den Akker-van Marle, EM, Lamb, HJ, Longo, VD et al.. Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial. Diabetologia. 2024;67 (7):1245-1259. doi: 10.1007/s00125-024-06137-0. PubMed PMID:38546821 PubMed Central PMC11153305.
  14. Sanches, FL, Weis, CMSC, Gonçalves, GCV, Andrade, GS, Diniz, LGT, Camargo, AF et al.. Study and characterization of a product based on a vegetable extract of quinoa fermented with water kefir grains. World J Microbiol Biotechnol. 2024;40 (4):118. doi: 10.1007/s11274-024-03943-x. PubMed PMID:38429465 .
  15. Brandhorst, S, Levine, ME, Wei, M, Shelehchi, M, Morgan, TE, Nayak, KS et al.. Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nat Commun. 2024;15 (1):1309. doi: 10.1038/s41467-024-45260-9. PubMed PMID:38378685 PubMed Central PMC10879164.
  16. Raucci, F, Vernieri, C, Di Tano, M, Ligorio, F, Blaževitš, O, Lazzeri, S et al.. Cyclic Fasting-Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia. Cancer Res. 2024;84 (7):1133-1148. doi: 10.1158/0008-5472.CAN-23-0295. PubMed PMID:38241703 PubMed Central PMC10982641.
  17. Giuliani, G, Longo, VD. Ketone bodies in cell physiology and cancer. Am J Physiol Cell Physiol. 2024;326 (3):C948-C963. doi: 10.1152/ajpcell.00441.2023. PubMed PMID:38189128 .
  18. Mirisola, MG, Longo, VD. Inactivation of Ymr1, Sjl2/3 phosphatases promotes stress resistance and longevity in wild type and Ras2G19V yeast. Biomed J. 2024;47 (2):100694. doi: 10.1016/j.bj.2023.100694. PubMed PMID:38154617 PubMed Central PMC10950826.
  19. Mishra, A, Giuliani, G, Longo, VD. Nutrition and dietary restrictions in cancer prevention. Biochim Biophys Acta Rev Cancer. 2024;1879 (1):189063. doi: 10.1016/j.bbcan.2023.189063. PubMed PMID:38147966 .
  20. Buono, R, Tucci, J, Cutri, R, Guidi, N, Mangul, S, Raucci, F et al.. Fasting-Mimicking Diet Inhibits Autophagy and Synergizes with Chemotherapy to Promote T-Cell-Dependent Leukemia-Free Survival. Cancers (Basel). 2023;15 (24):. doi: 10.3390/cancers15245870. PubMed PMID:38136414 PubMed Central PMC10741737.
  21. Cortellino, S, Quagliariello, V, Delfanti, G, Blaževitš, O, Chiodoni, C, Maurea, N et al.. Fasting mimicking diet in mice delays cancer growth and reduces immunotherapy-associated cardiovascular and systemic side effects. Nat Commun. 2023;14 (1):5529. doi: 10.1038/s41467-023-41066-3. PubMed PMID:37684243 PubMed Central PMC10491752.
  22. Cortellino, S, Longo, VD. Metabolites and Immune Response in Tumor Microenvironments. Cancers (Basel). 2023;15 (15):. doi: 10.3390/cancers15153898. PubMed PMID:37568713 PubMed Central PMC10417674.
  23. Kender, Z, von Rauchhaupt, E, Schwarz, D, Tsilingiris, D, Schimpfle, L, Bartl, H et al.. Six-month periodic fasting does not affect somatosensory nerve function in type 2 diabetes patients. Front Endocrinol (Lausanne). 2023;14 :1143799. doi: 10.3389/fendo.2023.1143799. PubMed PMID:37251671 PubMed Central PMC10213657.
  24. Blaževitš, O, Di Tano, M, Longo, VD. Fasting and fasting mimicking diets in cancer prevention and therapy. Trends Cancer. 2023;9 (3):212-222. doi: 10.1016/j.trecan.2022.12.006. PubMed PMID:36646607 .
  25. Maragkakis, M, Malla, S, Hatzoglou, M, Trifunovic, A, Glick, AB, Finkel, T et al.. Biology of Stress Responses in Aging. Aging Biol. 2023;1 :. doi: 10.59368/agingbio.20230001. PubMed PMID:38500537 PubMed Central PMC10947073.
  26. Lobo, F, Haase, J, Brandhorst, S. The Effects of Dietary Interventions on Brain Aging and Neurological Diseases. Nutrients. 2022;14 (23):. doi: 10.3390/nu14235086. PubMed PMID:36501116 PubMed Central PMC9740746.
  27. Di Tano, M, Longo, VD. Fasting and cancer: from yeast to mammals. Int Rev Cell Mol Biol. 2022;373 :81-106. doi: 10.1016/bs.ircmb.2022.02.005. PubMed PMID:36283768 .
  28. Brandhorst, S, Clark, DL. Food security for survivors of intimate partner violence: Understanding the role of food in survivor well-being. Health Soc Care Community. 2022;30 (6):e6267-e6275. doi: 10.1111/hsc.14064. PubMed PMID:36251587 PubMed Central PMC10092206.
  29. Brandhorst, S, Longo, VD. Breakfast keeps hunger in check. Cell Metab. 2022;34 (10):1420-1421. doi: 10.1016/j.cmet.2022.09.015. PubMed PMID:36198286 .
  30. Rangan, P, Lobo, F, Parrella, E, Rochette, N, Morselli, M, Stephen, TL et al.. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell Rep. 2022;40 (13):111417. doi: 10.1016/j.celrep.2022.111417. PubMed PMID:36170815 PubMed Central PMC9648488.
  31. Cortellino, S, Raveane, A, Chiodoni, C, Delfanti, G, Pisati, F, Spagnolo, V et al.. Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects. Cell Rep. 2022;40 (8):111256. doi: 10.1016/j.celrep.2022.111256. PubMed PMID:36001966 .
  32. Mishra, A, Longo, VD. Fasting and Fasting Mimicking Diets in Obesity and Cardiometabolic Disease Prevention and Treatment. Phys Med Rehabil Clin N Am. 2022;33 (3):699-717. doi: 10.1016/j.pmr.2022.04.009. PubMed PMID:35989059 .
  33. Gregor, A, Huber, L, Auernigg-Haselmaier, S, Sternberg, F, Billerhart, M, Dunkel, A et al.. A Comparison of the Impact of Restrictive Diets on the Gastrointestinal Tract of Mice. Nutrients. 2022;14 (15):. doi: 10.3390/nu14153120. PubMed PMID:35956298 PubMed Central PMC9370610.
  34. Mirisola, MG, Longo, VD. Yeast Chronological Lifespan: Longevity Regulatory Genes and Mechanisms. Cells. 2022;11 (10):. doi: 10.3390/cells11101714. PubMed PMID:35626750 PubMed Central PMC9139625.
  35. Fay-Watt, V, O'Connor, S, Roshan, D, Romeo, AC, Longo, VD, Sullivan, FJ et al.. Correction: The impact of a fasting mimicking diet on the metabolic health of a prospective cohort of patients with prostate cancer: a pilot implementation study. Prostate Cancer Prostatic Dis. 2023;26 (2):435. doi: 10.1038/s41391-022-00540-7. PubMed PMID:35585259 PubMed Central PMC10247363.
  36. Longo, VD, Anderson, RM. Nutrition, longevity and disease: From molecular mechanisms to interventions. Cell. 2022;185 (9):1455-1470. doi: 10.1016/j.cell.2022.04.002. PubMed PMID:35487190 PubMed Central PMC9089818.
  37. Fay-Watt, V, O'Connor, S, Roshan, D, Romeo, AC, Longo, VD, Sullivan, FJ et al.. The impact of a fasting mimicking diet on the metabolic health of a prospective cohort of patients with prostate cancer: a pilot implementation study. Prostate Cancer Prostatic Dis. 2023;26 (2):317-322. doi: 10.1038/s41391-022-00528-3. PubMed PMID:35314788 PubMed Central PMC10247368.
  38. Rahmani, J, Montesanto, A, Giovannucci, E, Zand, H, Barati, M, Kopchick, JJ et al.. Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Aging Cell. 2022;21 (2):e13540. doi: 10.1111/acel.13540. PubMed PMID:35048526 PubMed Central PMC8844108.
  39. Nardon, M, Venturelli, M, Ruzzante, F, Longo, VD, Bertucco, M. Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial. Eur J Appl Physiol. 2022;122 (3):651-661. doi: 10.1007/s00421-021-04867-2. PubMed PMID:35034194 .
  40. Canali, I, Rosito, LPS, Longo, VD, Costa, SSD. Critical analysis of moderate and severe retractions in the pars tensa and pars flaccida of the tympanic membrane. Braz J Otorhinolaryngol. 2023;89 (1):114-121. doi: 10.1016/j.bjorl.2021.10.005. PubMed PMID:34896036 PubMed Central PMC9874355.
  41. Vernieri, C, Fucà, G, Ligorio, F, Huber, V, Vingiani, A, Iannelli, F et al.. Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer. Cancer Discov. 2022;12 (1):90-107. doi: 10.1158/2159-8290.CD-21-0030. PubMed PMID:34789537 PubMed Central PMC9762338.
  42. Diaz-Ruiz, A, Rhinesmith, T, Pomatto-Watson, LCD, Price, NL, Eshaghi, F, Ehrlich, MR et al.. Diet composition influences the metabolic benefits of short cycles of very low caloric intake. Nat Commun. 2021;12 (1):6463. doi: 10.1038/s41467-021-26654-5. PubMed PMID:34753921 PubMed Central PMC8578605.
  43. Salvadori, G, Zanardi, F, Iannelli, F, Lobefaro, R, Vernieri, C, Longo, VD et al.. Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape. Cell Metab. 2021;33 (11):2247-2259.e6. doi: 10.1016/j.cmet.2021.10.008. PubMed PMID:34731655 PubMed Central PMC8769166.
  44. Pomatto-Watson, LCD, Bodogai, M, Bosompra, O, Kato, J, Wong, S, Carpenter, M et al.. Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition. Nat Commun. 2021;12 (1):6201. doi: 10.1038/s41467-021-26431-4. PubMed PMID:34707136 PubMed Central PMC8551193.
  45. Salvadori, G, Longo, VD. Diet comparison suggests a lipid imbalance can slow tumour growth. Nature. 2021;599 (7884):206-207. doi: 10.1038/d41586-021-02775-1. PubMed PMID:34671149 .
  46. Mishra, A, Mirzaei, H, Guidi, N, Vinciguerra, M, Mouton, A, Linardic, M et al.. Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan. Nat Metab. 2021;3 (10):1342-1356. doi: 10.1038/s42255-021-00469-6. PubMed PMID:34650272 .
  47. Salvadori, G, Mirisola, MG, Longo, VD. Intermittent and Periodic Fasting, Hormones, and Cancer Prevention. Cancers (Basel). 2021;13 (18):. doi: 10.3390/cancers13184587. PubMed PMID:34572814 PubMed Central PMC8472354.
  48. Valdemarin, F, Caffa, I, Persia, A, Cremonini, AL, Ferrando, L, Tagliafico, L et al.. Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment. Cancers (Basel). 2021;13 (16):. doi: 10.3390/cancers13164013. PubMed PMID:34439167 PubMed Central PMC8391327.
  49. Canali, I, Schmidt Rosito, LP, Longo, VD, Victor de Andrade Águas, J, Selaimen da Costa, S. Comparative analysis of moderate and severe tympanic membrane retractions in children and adults. Int J Pediatr Otorhinolaryngol. 2021;147 :110784. doi: 10.1016/j.ijporl.2021.110784. PubMed PMID:34058531 .
  50. Canali, I, Rosito, LPS, Longo, VD, da Costa, SS. Audiometric Pattern in Moderate and Severe Tympanic Membrane Retraction. Otol Neurotol. 2021;42 (6):e716-e723. doi: 10.1097/MAO.0000000000003099. PubMed PMID:33625199 .
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