Estradiol treatment after menopause may protect against effects of stress on memory

Alexandra Ycaza Herrera, PhD, a post-doctoral scholar in the Emotion & Cognition Lab, recently published a study on the effects of post-menopausal hormone replacement on cortisol response to stress and the subsequent effects of stress on memory. The study was published Nov. 2 in The Journal of Clinical Endocrinology and Metabolism.

Stress hinders recall

The researchers found that women taking estrogen-only therapy had lower levels of the stress hormone cortisol and performed better on tests of “working memory” following exposure to stress compared to women taking a placebo.

Working memory allows the brain to keep information immediately available for processing, such as when a shopper uses a mental grocery list to pick up items or when a student keeps specific numbers in mind as a teacher reads a word problem aloud in math class. Studies have documented that stress can impair working memory.

To measure the effect of estrogen therapy on working memory under stress, Ycaza Herrera recruited 42 women with an average age of 66 from the USC Early versus Late Intervention Trial with Estradiol led by Howard Hodis, a professor at the Keck School of Medicine of USC and a co-author of the study.

Half of the postmenopausal women had been on estradiol, a type of estrogen therapy, for approximately five years, while the others had received a placebo.

Each participant visited USC twice. To induce a stress response during one visit, researchers asked participants to submerge their hand in ice water for about three minutes. For the control condition conducted during the other visit, the participants submerged their hand in warm water.

Before and after each visit, the researchers collected saliva to measure the women’s levels of cortisol, estrogen, and progesterone. The researchers also ran a test of working memory called a “sentence span task,” in which the women were each given a series and then asked whether each sentence made sense. They also were asked to recall the last word of each one.

Not right for every woman

All women performed equally well on the sentence span task after the warm water condition. But after the ice bath, women taking the placebo experienced a spike in cortisol levels. They also demonstrated a decrease in working memory function.

By contrast, women receiving estrogen therapy had a smaller increase in cortisol and showed no decrease in working memory function.

“Hormone replacement therapy may not be right for every woman, but women need to be able to have the conversation with their doctors,” Ycaza Herrera said.

The study was also co-authored by Wendy Mack, a Keck School professor of preventive medicine, and Mara Mather, a USC Leonard Davis School professor of gerontology.

The study, along with the larger ELITE trial and other studies investigating stress-hormone relationships, was 100-percent funded by a combined $2 million in grant funds from the National Institute on Aging (grant numbers R01AG-024154, R01AG-038043 and R21AG-048463).”

Read the original USC News story here: