Publications

  1. Kumagai, H, Natsume, T, Kim, SJ, Tobina, T, Miyamoto-Mikami, E, Shiose, K et al.. The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance. Biochim Biophys Acta Gen Subj. 2022;1866 (2):130048. doi: 10.1016/j.bbagen.2021.130048. PubMed PMID:34728329 PubMed Central PMC8741734.
  2. Kim, SJ, Devgan, A, Miller, B, Lee, SM, Kumagai, H, Wilson, KA et al.. Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension. Biochim Biophys Acta Gen Subj. 2022;1866 (1):130017. doi: 10.1016/j.bbagen.2021.130017. PubMed PMID:34624450 PubMed Central PMC8595716.
  3. DeVito, LM, Barzilai, N, Cuervo, AM, Niedernhofer, LJ, Milman, S, Levine, M et al.. Extending human healthspan and longevity: a symposium report. Ann N Y Acad Sci. 2021; :. doi: 10.1111/nyas.14681. PubMed PMID:34498278 .
  4. Sequeira, IR, Woodhead, JST, Chan, A, D'Souza, RF, Wan, J, Hollingsworth, KG et al.. Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes. Biochim Biophys Acta Gen Subj. 2021;1865 (11):129991. doi: 10.1016/j.bbagen.2021.129991. PubMed PMID:34419510 .
  5. Dieli-Conwright, CM, Sami, N, Norris, MK, Wan, J, Kumagai, H, Kim, SJ et al.. Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors. Sci Rep. 2021;11 (1):16916. doi: 10.1038/s41598-021-96419-z. PubMed PMID:34413391 PubMed Central PMC8376922.
  6. von Walden, F, Fernandez-Gonzalo, R, Norrbom, J, Emanuelsson, EB, Figueiredo, VC, Gidlund, EK et al.. Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans. J Appl Physiol (1985). 2021;131 (3):1035-1042. doi: 10.1152/japplphysiol.00706.2019. PubMed PMID:34351816 .
  7. Lei, S, Inojosa, JRM, Kumar, S, Lee, AT, Scott, CG, Lerman, A et al.. Effectiveness of a Weight Loss Program Using Digital Health in Adolescents and Preadolescents. Child Obes. 2021;17 (5):311-321. doi: 10.1089/chi.2020.0317. PubMed PMID:33826417 PubMed Central PMC8236388.
  8. Kumagai, H, Coelho, AR, Wan, J, Mehta, HH, Yen, K, Huang, A et al.. MOTS-c reduces myostatin and muscle atrophy signaling. Am J Physiol Endocrinol Metab. 2021;320 (4):E680-E690. doi: 10.1152/ajpendo.00275.2020. PubMed PMID:33554779 PubMed Central PMC8238132.
  9. Reynolds, JC, Lai, RW, Woodhead, JST, Joly, JH, Mitchell, CJ, Cameron-Smith, D et al.. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12 (1):470. doi: 10.1038/s41467-020-20790-0. PubMed PMID:33473109 PubMed Central PMC7817689.
  10. Zempo, H, Kim, SJ, Fuku, N, Nishida, Y, Higaki, Y, Wan, J et al.. A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c. Aging (Albany NY). 2021;13 (2):1692-1717. doi: 10.18632/aging.202529. PubMed PMID:33468709 PubMed Central PMC7880332.
  11. Zhao, Y, Zhou, L, Li, H, Sun, T, Wen, X, Li, X et al.. Nuclear-Encoded lncRNA MALAT1 Epigenetically Controls Metabolic Reprogramming in HCC Cells through the Mitophagy Pathway. Mol Ther Nucleic Acids. 2021;23 :264-276. doi: 10.1016/j.omtn.2020.09.040. PubMed PMID:33425485 PubMed Central PMC7773746.
  12. Miller, B, Silverstein, A, Flores, M, Cao, K, Kumagai, H, Mehta, HH et al.. Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples. Sci Rep. 2021;11 (1):3. doi: 10.1038/s41598-020-79552-z. PubMed PMID:33420163 PubMed Central PMC7794290.
  13. Jia, Y, Swerdloff, RS, Lue, Y, Dai-Ju, J, Surampudi, P, Cohen, P et al.. The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†. Biol Reprod. 2021;104 (3):717-730. doi: 10.1093/biolre/ioaa225. PubMed PMID:33330922 PubMed Central PMC8527998.
  14. Silverstein, AR, Flores, MK, Miller, B, Kim, SJ, Yen, K, Mehta, HH et al.. Mito-Omics and immune function: Applying novel mitochondrial omic techniques to the context of the aging immune system. Transl Med Aging. 2020;4 :132-140. doi: 10.1016/j.tma.2020.08.001. PubMed PMID:32844137 PubMed Central PMC7441040.
  15. Miller, B, Torres, M, Jiang, X, McKean-Cowdin, R, Nousome, D, Kim, SJ et al.. A Mitochondrial Genome-Wide Association Study of Cataract in a Latino Population. Transl Vis Sci Technol. 2020;9 (6):25. doi: 10.1167/tvst.9.6.25. PubMed PMID:32821522 PubMed Central PMC7408807.
  16. Yen, K, Mehta, HH, Kim, SJ, Lue, Y, Hoang, J, Guerrero, N et al.. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging (Albany NY). 2020;12 (12):11185-11199. doi: 10.18632/aging.103534. PubMed PMID:32575074 PubMed Central PMC7343442.
  17. Miller, B, Kim, SJ, Kumagai, H, Mehta, HH, Xiang, W, Liu, J et al.. Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications. Exp Cell Res. 2020;393 (2):112056. doi: 10.1016/j.yexcr.2020.112056. PubMed PMID:32387288 PubMed Central PMC7778388.
  18. Woodhead, JST, D'Souza, RF, Hedges, CP, Wan, J, Berridge, MV, Cameron-Smith, D et al.. High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. J Appl Physiol (1985). 2020;128 (5):1346-1354. doi: 10.1152/japplphysiol.00032.2020. PubMed PMID:32271093 PubMed Central PMC7717117.
  19. D'Souza, RF, Woodhead, JST, Hedges, CP, Zeng, N, Wan, J, Kumagai, H et al.. Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition. Aging (Albany NY). 2020;12 (6):5244-5258. doi: 10.18632/aging.102944. PubMed PMID:32182209 PubMed Central PMC7138593.
  20. Gluck, O, Pinchas-Cohen, T, Hiaev, Z, Rubinstein, H, Bar, J, Kovo, M et al.. The impact of childbirth education classes on delivery outcome. Int J Gynaecol Obstet. 2020;148 (3):300-304. doi: 10.1002/ijgo.13016. PubMed PMID:31912479 .
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