The study and treatment of traumatic brain injury (TBI) in older adults is of high clinical priority. We use multimodal neuroimaging (MRI, DTI, PET), electrophysiology measurements (EEG) and computational models to study how brain aging and the subsequent degradation of its function are affected by TBI. Throughout the past 15+ years, approaches afforded by fields as varied as nonlinear dynamics, network theory, machine learning, multivariate statistics and scientific visualization have allowed us to quantify functional abnormalities of the nervous system and to contribute to the development of novel, patient-tailored approaches to clinical patient care. We have developed the connectogram (left), an attractive approach for the mapping and visualization of brain wiring. In conjunction with network-theoretic analysis, connectograms have been adopted at 100+ research centers worldwide and its growing use has been highlighted prominently by Nature, Nature Methods, Discovery Magazine, the New York Times, the Los Angeles Times, CNN, NBC, etc.