The past several decades have witnessed remarkable progress on elucidating the disease mechanisms of the aging brain. Imaging technologies have allowed scientists to map neural network dynamics in exquisite detail, with noteworthy consequences for medicine and society. In our laboratory, we leverage neuroimaging and electrophysiology to study neurovascular injury, trauma-induced neural plasticity and atypical neurodegeneration. We integrate brain mapping techniques with machine intelligence and computational biology approaches to investigate how brain connectivity alterations caused by vascular brain injury add to the neurocognitive deficits of aging victims of concussions, cerebral amyloid angiopathy or dementia. We are interested in how vascular disease affects brain aging trajectories, and in the relationship between brain trauma and neurodegenerative diseases. Our extensive experience with the bioinformatics and quantitative analysis of neuroimaging data has allowed us to pioneer award-winning approaches for the analysis and visualization of brain connectivity. The laboratory has also made important discoveries on the reorganization and plasticity of neural connections after brain trauma. We have obtained unique insights into the relationship between neural injury, brain plasticity and neurodegenerative disease, many of which have been popularized in science magazines and neuroscience textbooks.
Associate Professor of Gerontology, Quantitative & Computational Biology, Biomedical Engineering and Neuroscience
USC Leonard Davis School of Gerontology
Office Location: GER 228C
Primary Research Areas
- Deep learning to study brain aging
- The relationship between traumatic brain injury and dementia
- Neurovascular calcification
Recent News
- Brilliant minds, healthy brainsby USC Leonard Davis Communications on December 4, 2024 at 6:16 pm
- Anonymous gift advances Alzheimer’s researchby USC Leonard Davis Communications on June 21, 2023 at 8:59 pm
- For clues to healthy brain aging, look to the Bolivian Amazonby USC Leonard Davis Communications on March 20, 2023 at 9:56 pm
- How old is your brain, really? Artificial intelligence knowsby Beth Newcomb on January 11, 2023 at 11:32 pm
- Neuroscience Student, USC Leonard Davis Lab Member Wins Prestigious Goldwater Scholarshipby Beth Newcomb on April 13, 2022 at 4:00 pm
- Amazon Tribes May Have Lowest Rate of Dementia in the World (U.S. News & World Report)by Beth Newcomb on March 21, 2022 at 6:41 pm
- Some of the World’s Lowest Dementia Rates are Found in Amazonian Indigenous Groupsby Beth Newcomb on March 11, 2022 at 9:22 pm
- World Alzheimer’s Month: Andrei Irimia discusses brain health and the relationship between concussions and Alzheimer’sby USC Leonard Davis Communications on September 3, 2021 at 8:32 pm
Social Media
Anonymous gift advances Alzheimer’s research!
— Irimia Lab (@irimia_lab) June 22, 2023
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