Selected Publications


Christensen A and Pike CJ (2023) Effects of APOE genotype and Western diet on metabolic phenotypes in female mice. Metabolites13: 287.

Valencia-Olvera AC, Maldonado Weng J, Christensen A, LaDu MJ, and Pike CJ (2022) Role of estrogen in women’s Alzheimer’s disease risk as modified by APOEJournal of Neuroendocrinology. Oct 20;e13209. doi: 10.1111/jne.13209

Rangan P, Lobo F, Parrella E, Rochette N, Morselli M, Stephen T, Cremonini AL, Tagliafico L, Monacelli F, Odetti P, Nencioni A, Pike CJ, LaDu MJ, Pellegrini M, Xia K, Tran K, Ann B, Chowdhury D and Longo VD (2022) A fasting-mimicking diet reduces neuroinflammation/Nox2 to attenuate cognitive decline in mouse models of Alzheimer’s disease. Cell Reports 40 (13): 111417

Stephen T, Breningstall B, Suresh S, McGill CJ, and Pike CJ (2022) APOE genotype and biological sex regulate astroglial interactions with amyloid plaques in Alzheimer’s disease mice. Journal of Neuroinflammation. 19: 286 (2022).

Moser AM, Workman MJ, Hurwitz SJ, Lipman RM, Pike CJ, and Svendsen CN (2021) A novel transcription profile in mouse and human microglia is driven by APOE4 and sex. iScience 24 (11): 103238

Jiang J, Young, and Pike CJ (2020) Second to fourth digit ratio (2D:4D) is associated with dementia in women. Early Human Development. 149:105152.

Luo J, Beam CR, Karlsson IK, Pike CJ, Pedersen NL, and Gatz M. (2020) Dementia risk in women higher in same-sex than opposite-sex twins.  Alzheimer’s & Dementia (Amst) 12 (1): e12049.

Christensen A, Liu J, and Pike CJ (2020) Aging reduces estradiol protection against neural but not metabolic effects of obesity in female 3xTg-AD mice. Frontiers in Aging Neuroscience. May 5;12:113.

Christensen A and Pike CJ (2020) Staining and quantification of beta-amyloid pathology in transgenic mouse models of Alzheimer’s disease. In: Aging. Methods in Molecular Biology (editor, Curran SP), Vol 2144. Humana, New York, NY.

Stephen T, Cacciottolo M, Balu D, Morgan TE, LaDu MJ, Finch CE, and Pike CJ (2019) APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease mice. Acta Neuropathologica Communications 7(1):82.

Moser VA, Christensen AK, Liu J, Zhou A, Yagi S, Beam CR, Galea LAM, Pike CJ (2019) Effects of aging and testosterone treatment on neural and metabolic outcomes of high-fat diet in male brown Norway rats. Neurobiology of Aging Sep 22 73: 145-160.

Christensen A and Pike CJ (2019) APOE genotype affects metabolic and Alzheimer-related outcomes induced by Western diet in female EFAD mice. FASEB J 33(3):4054-4066.

Moser VA, Uchoa MF, Pike CJ (2018) TLR4 antagonist TAK-242 blocks the adverse neural effects of diet-induced obesity. Journal of Neuroinflammation 15(1):306.

Moser VA and Pike CJ (2017) Obesity accelerates Alzheimer-related pathology in APOE4 but not APOE3 mice. eNeuro 4(3) pii: ENEURO.0077-17.2017.

Christensen A and Pike CJ (2017) Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice. PLoS One 12(6): e0178490.

Pike CJ (2017) Sex and the development of Alzheimer’s disease. Journal of Neuroscience Research. 95: 671-680.

Uchoa MF, Moser VA, and Pike CJ (2016) Interactions between inflammation, sex steroids, and Alzheimer’s disease risk factors. Frontiers in Neuroendocrinology. 43: 60-82.

Moser VA and Pike CJ (2016) Obesity and sex interact in the regulation of Alzheimer’s disease. Neuroscience & Biobehavioral Reviews. 67: 102-118.

Christensen A and Pike CJ (2015) Menopause, obesity and inflammation: Interactive risk factors for Alzheimer’s disease. Frontiers in Aging Neuroscience. 7: 130.

Barron AM, Brown MA, Morgan TE and Pike CJ (2015) Impact of continuous versus discontinuous progesterone on estradiol regulation of neuronal viability and sprouting following entorhinal cortex lesion in female rats. Endocrinology 156 (3): 1091-1099.

Jayaraman A, Lent D and Pike CJ (2014) Diet-induced obesity and low testosterone increase neuroinflammation and reduce neuron survival. Journal of Neuroinflammation 11 (1): 162.

Jayaraman A and Pike CJ (2014) Differential effects of synthetic progestagens on neuron survival and estrogen neuroprotection in cultured neurons. Molecular and Cellular Endocrinology 384 (1-2): 52-60.

Jayaraman A and Pike CJ (2014) Alzheimer’s disease and type 2 diabetes: Multiple mechanisms contribute to interactions. Current Diabetes Reports 14 (4): 476.

 Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike CJ (2014) Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats.  Endocrinology 155 (4): 1398-1406.

Barron AM, Rosario ER, Brown MA, Eltereifi R, and Pike CJ (2013) Sex-specific effects of high-fat diet on indices of metabolic syndrome in 3xTg-AD mice: Implications for Alzheimer’s disease. PLoS ONE 8 (10): e78554.

Barron AM, Garcia-Segura LM, Caruso D, Jayaraman A, Lee JW, Melcangi RC, and Pike CJ (2013) Ligand for translocator protein reverses pathology in a mouse model of Alzheimer’s disease. Journal of Neuroscience 33 (20): 8891-8897.

Vest RS and Pike CJ (2013) Gender, sex steroids, and Alzheimer’s disease. Hormones and Behavior 63: 301-307.

Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, and Pike CJ (2012) 17b-Estradiol and progesterone regulate expression of b-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology 153 (11): 5467-5479.

Rosario ER, Carroll JC, and Pike CJ (2012) Evaluation of the effects of testosterone and luteinizing hormone on regulation of b-amyloid in male 3xTg-AD mice.  Brain Research 1466: 137-145.

Aras R, Barron AM, and Pike CJ (2012) Caspase activation contributes to astrogliosis. Brain Research 1450: 102-115.

Rosario ER, Chang L, Head EH, Stanczyk FZ, and Pike CJ (2011) Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer’s disease. Neurobiology of Aging 32 (4): 604-613.

Carroll JC, Rosario ER, Kreimer S, Villamagna A, Gentzschein E, Stanczyk FZ, and Pike CJ (2010) Sex differences in b-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure. Brain Research 1366: 233-245.

Nguyen TV, Jayaraman A, and Pike CJ (2010) Androgens selectively protect against apoptosis in hippocampal neurones. Journal of Neuroendocrinology 22 (9): 1013-1022.

Carroll JC, Rosario ER, Villamagna A, and Pike CJ (2010) Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTg-AD mice. Endocrinology 151 (6): 2713-2722.

Pike CJ, Carroll JC, Rosario ER, and Barron A (2009) Protective actions of sex steroid hormones in Alzheimer’s disease. Frontiers in Neuroendocrinology. 30 (2): 239-58.

Jayaraman A and Pike CJ (2009) Progesterone attenuates oestrogen neuroprotection by downregulation of oestrogen receptor expression in cultured neurones. Journal of Neuroendocrinology 21 (1): 77-81.

Pike CJ, Nguyen TV, Yao M, Murphy MP, and Rosario ER (2008) Androgen cell signaling pathways involved in neuroprotective actions. Hormones and Behavior 53: 693-705.

Yao M, Nguyen TV, Rosario ER, Ramsden M, and Pike CJ (2008) Androgens regulate neprilysin expression: Role in reducing b-amyloid levels.  Journal of Neurochemistry 105: 2477-2488.

Carroll JC and Pike CJ (2008) Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice. Endocrinology 149: 2607-2611.

Carroll JC, Rosario ER, Chan L, Stanczyk FZ, Oddo S, LaFerla FM, and Pike CJ (2007) Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. Journal of Neuroscience 27:13357-13365.

Nguyen TV, Yao M, and Pike CJ (2007) Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotection. Endocrinology 148:2936-2943.

Yao M, Nguyen TV, and Pike CJ (2007) Estrogen prevents b-amyloid peptide induced neuronal death by regulating Bcl-w and Bim expression. Journal of Neuroscience, 27: 1422-1433.

Rosario ER, Carroll JC, Oddo S, LaFerla FM, and Pike CJ (2006) Androgens regulate development of neuropathology in a triple transgenic mouse model of Alzheimer’s disease. Journal of Neuroscience 26: 13384-13389.

Yao M, Nguyen T-V, and Pike CJ (2005) b-Amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w. Journal of Neuroscience 25: 1149-1158.

Rosario ER, Chang L. Stanczyk FZ, and Pike CJ (2004) Age-related testosterone depletion and the development of Alzheimer’s disease. Journal of the American Medical Association (JAMA) 292: 1431-1432.