Research in the Pike Lab is broadly focused on Alzheimer’s disease (AD), with the general goals of elucidating factors that regulate AD pathogenesis and pursuing translational strategies for the prevention and treatment of the disease. Our approach to investigating research questions involves the use of complementary cellular, biochemical and molecular techniques to analyze relationships in human tissues, non-transgenic and transgenic rodent models, and cultured cells. Current areas of research focus in the Pike Lab include the role of obesity in AD risk, the contributions of the genetic risk factor APOE4 to AD pathogenesis, sex differences in AD, the relationships between age-related losses of steroid hormones and the development of AD, and interactions among these areas. We seek to identify and elucidate the mechanisms underlying AD risks and use this information to develop therapeutic interventions.
In the News
- Alzheimer’s Affects Men and Women Differentlyon June 20, 2019
Professor Christian Pike’s research on sex differences in Alzheimer’s disease could help inform how we might one […]
- New Research Directions Aim to Aid Alzheimer’s Disease Treatment and Preventionon November 9, 2017
During this year’s National Alzheimer’s Disease Awareness Month, USC Leonard Davis School of Gerontology faculty […]
- Healthy Diet Might Spare Those With Alzheimer’s Gene From Developing Disease: Study (City News Service)on June 19, 2017
City News Service highlighted research by Christian Pike of the USC Leonard Davis School on how individuals that carry […]