The primary goal of the Vermulst laboratory is to identify the basic mechanisms that control human aging. The identification of these mechanisms would provide pivotal insight into the etiology of numerous age-related diseases, including cancer, neurodegeneration and heart disease. Thus, by elucidating the basic biology that underlies human aging, it may be possible to provide new treatments for various diseases that are currently endemic in Western society. This rationale shapes the research performed in the lab and ensures that it always operates at the crossroads between basic biology and medical urgency. The main focus areas of the Vermulst lab are the following:

Mitochondrial protein heterogeneity

Transcription errors

Mitochondrial mutagenesis