Publications

Vermulst M, Bielas JH, Kujoth GC, Ladiges WG, Rabinovitch PS, Prolla TA and Loeb LA. (2007) Mitochondrial point mutations do not limit the natural lifespan of mice. Nature Genetics 39, 540-543. PMID: 17334366 | PDF

Associated Commentary: Mitochondrial DNA mutations and aging: a case closed? Konstantin Khrapko and Jan Vijg. (2007) Nature Genetics 39, 445-446.

Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA and Loeb LA. (2008) DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nature Genetics 40, 392-394. PMID: 18311139 | PDF

Vermulst M, Bielas, JH and Loeb, LA. (2008) Quantification of mutation in the mitochondrial genome. Methods 46, 263‐268. PMID: 18948200. PMCID:PMC2615251 | PDF

Dai D, Santana LF, Vermulst M, Tomazeva DM, Emond MJ, Macoss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC and Rabinovitch PS (2009). Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation 119, 2789-2797. PMID: 19451351. PMCID: PMC2858759 | PDF

Vermulst M, Wanagat J and Loeb LA. (2009) On mitochondria, mutations, and methodology. Cell Metabolism 10, 437. PMID: 19945399 | PDF

Chen HC*, Vermulst M*, Wang YE, Prolla TA, McCaffery MJ and Chan DC. (2010) Mitochondrial fusion is required for mtDNA stability and tolerance of mtDNA mutations. Cell 141, 280‐289. PMID: 20403324. PMCID: PMC2858759  * equal contributors | PDF

Ericson N, Kulawiec M, Vermulst M, Sheahan K, O’Sullivan J, Salk J and Bielas JH. (2012) Decreased mitochondrial DNA mutagenesis in human colorectal cancer. PLoS Genetics 8, e1002689. doi: 10.1371/journal.pgen.1002689. Epub 2012 Jun 7. PMID: 22685414. PMCID:PMC3369930. | PDF

Vermulst M, Khrapko K and Wanagat J. (2012) Mitochondrial mutagenesis in aging and disease. Book chapter for Mutagenesis,  ISBN 978-953-51-0707-1 | PDF

Vermulst M, Denney AS, Lang MJ, Hung CW, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Cyr D, Kaeberlein M, Strathern JN, Duncan MC and Erie D. Transcription errors induce proteotoxic stress and shorten cellular lifespan. (Nature Communications, 6, article 8065, Aug. 25, 2015) | PDF

Haroon S, Vermulst M. Linking mitochondrial dynamics to mitochondrial protein quality control. Curr Opin Genet Dev. 2016 Jun;38:68-74. doi: 10.1016/j.gde.2016.04.004. Epub 2016 May 25. Review. | PDF

Someya S, Kujoth GC, Kim MJ, Hacker TA, Vermulst M, Weindruch R, Prolla TA. Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice. PLoS One. 2017 Feb 3;12(2):e0171159. doi: 10.1371/journal.pone.0171159. eCollection 2017. | PDF

J.-F. Gout, Weiyi Li, C. Fritsch, A. Li, S. Haroon, L. Singh, D. Hua, H. Fazelina, Z. Smith, S, Seeholzer, K. Thomas, M. Lynch, M. Vermulst. The landscape of transcription errors in eukaryotic organisms. Science Advances, published online, October 20th 2017, Vol. 3. No. 10, e1701484. PMID: 29062891 | PDF

S. Haroon, A. Li, C. Fritsch, N. Ericson, J. Alexander-Floyd, B.P. Braeckman, C. Haynes, J. Bielas, T. Gidalevitz, M. Vermulst. Multiple molecular mechanisms rescue mtDNA disease in C. elegans. Cell Reports, Mar 20;22(12):3115-3125. PMID: 29562168 | PDF

Meagan J McManus, Hsiao-Wen Chen, Martin Picard, Hans J. De Haas, Prasanth Potluri, Jeremy Leipzig, Atif Towheed, Alessia Angelin, Partho Sengupta, Ryan M. Morrow, Brett A. Kauffman, Marc Vermulst, Jagat Narula, Douglas C. Wallace. Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy. Cell Metabolism, 2019 Jan 8;29(1):78-90.e5. doi: 10.1016/j.cmet.2018.08.002. Epub 2018 Aug 30

C. Fritsch, JF Gout, M. Vermulst. Transcription errors: A new horizon for mutation research. J Vis Exp. 2018 Sep 13;(139). doi: 10.3791/57731

Verheijen BM, Vermulst M, van Leeuwen FW. Somatic mutations in neurons during aging and neurodegeneration. Acta Neuropathol. 2018 Jun;135(6):811-826. doi: 10.1007/s00401-018-1850-y. Epub 2018 Apr 28. Review. | PDF