Publications
Shemtov SJ, McGann E, Carrillo L, Lee S, Anson H, Chung CS, Anagnostou ME, Lai GD, Verheijen BM, Wan J, Vorobyova I, Sanchez-Contreras M, Conover CA, Thorwald MA, Cohen P, Kennedy SR, Gout JF, Haroon S, Vermulst M. The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome. bioRxiv [Preprint]. 2025 Jun 6. doi: 10.1101/2025.06.03.656903. PMID: 40501628
Nat Commun. 2025 Jul 11;16(1):6425. doi: 10.1038/s41467-025-61555-x. PMID: 40645940
Sci Adv. 2025 Jul 11;11(28):eadv9898. doi: 10.1126/sciadv.adv9898. PMID: 40644547
Thorwald MA, Godoy-Lugo JA, Kerstiens E, Garcia G, Kim M, Shemtov SJ, Silva J, Durra S, O’Day PA, Mack WJ, Hiniker A, Vermulst M, Benayoun BA, Higuchi-Sanabria R, Forman HJ, Head E, Finch CE. Down syndrome with Alzheimer’s disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis. Alzheimers Dement. 2025 Jun;21(6):e70322. doi: 10.1002/alz.70322. PMID: 40536124
Curr Opin Genet Dev. 2025 Aug;93:102350. doi: 10.1016/j.gde.2025.102350. PMID: 40300213
Int J Mol Sci. 2024 Oct 24;25(21):11429. doi: 10.3390/ijms252111429.PMID: 39518982
Chung CS*, Kou Y*, Shemtov SJ*, Verheijen BM*, Flores I, Love K, Del Dosso A, Thorwald MA, Liu Y, Hicks D, Sun Y, Toney RG, Carrillo L, Nguyen MM, Biao H, Jin Y, Jauregui AM, Quiroz JD, Head E, Moore DL, Simpson S, Thomas KW, Coba MP, Li Z, Benayoun BA, Rosenthal JJC, Kennedy SR, Quadrato G, Gout JF, Chen L, Vermulst M. Transcript errors generate amyloid-like proteins in human cells. Nat Commun. 2024 Oct 7;15(1):8676. doi: 10.1038/s41467-024-52886-2. PMID: 39375347 *equal contributors
Vermulst M, Paskvan SL, Chung CS, Franke K, Clegg N, Minot S, Madeoy J, Long AS, Gout JF, Bielas JH. MADDD-seq, a novel massively parallel sequencing tool for simultaneous detection of DNA damage and mutations. Nucleic Acids Res. 2024 Sep 9;52(16):e76. doi: 10.1093/nar/gkae632. PMID: 39149908
Dinep-Schneider O, Appiah E, Dapper A, Patterson S, Vermulst M, Gout JF. Effects of the glyphosate-based herbicide roundup on C. elegans and S. cerevisiae mortality, reproduction, and transcription fidelity. Environ Pollut. 2024 Sep 1;356:124203. doi: 10.1016/j.envpol.2024.124203. PMID: 38830529
Wang S, Kim K, Gelvez N, Chung C, Gout JF, Fixman B, Vermulst M, Chen XS. Identification of RBM46 as a novel APOBEC1 cofactor for C-to-U RNA-editing activity. J Mol Biol. 2023 Dec 15;435(24):168333. doi: 10.1016/j.jmb.2023.168333. PMID: 38708190
Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Kim J, Torres TC, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, Vega M, Mehta HH, Thorwald MA, Crews P, Vermulst M, Garcia G, Johnson TA, Higuchi-Sanabria R. Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging. Geroscience. 2024 Dec;46(6):6009-6028. doi: 10.1007/s11357-024-01144-w. PMID: 38570396
Verheijen BM, Chung C, Thompson B, Kim H, Nakahara A, Anink JJ, Mills JD; NYGC ALS Consortium; Lee JH, Aronica E, Oyanagi K, Kakita A, Gout JF, Vermulst M.
The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis. Acta Neuropathol Commun. 2024 Feb 21;12(1):30. doi: 10.1186/s40478-024-01725-y. PMID: 38383591
Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M. Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold. PNAS. 2023 Dec 19. doi: 10.1101/2023.04.26.538417. PMID: 37162924
Chung C, Verheijen BM, Zhang X, Huang B, Coakley A, McGann E, Wade E, Dinep-Schneider O, LaGosh J, Anagnostou ME, Simpson S, Thomas K, Ernst M, Rattray A, Lynch M, Kashlev M, Benayoun BA, Li Z, Strathern J, Gout JF, Vermulst M. The fidelity of transcription in human cells. PNAS. 2023 Jan 31;120(5):e2210038120. doi: 10.1073/pnas.2210038120.
Chung C, Verheijen BM, Navapanich Z, McGann EG, Shemtov S, Lai GJ, Arora P, Towheed A, Haroon S, Holczbauer A, Chang S, Manojlovic Z, Simpson S, Thomas KW, Kaplan C, van Hasselt P, Timmers M, Erie D, Chen L, Gout JF, Vermulst M. Evolutionary conservation of the fidelity of transcription. Nat Commun. 2023 Mar 20;14(1):1547. doi: 10.1038/s41467-023-36525-w.
Fritsch C, Gout JF, Haroon S, Towheed A, Chung C, LaGosh J, McGann E, Zhang X, Song Y, Simpson S, Danthi PS, Benayoun BA, Wallace D, Thomas K, Lynch M, Vermulst M. Genome-wide surveillance of transcription errors in response to genotoxic stress. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2004077118. doi: 10.1073/pnas.2004077118. PMCID: PMC7817157.
Haroon S, Vermulst M. Oxygen Consumption Measurements in Caenorhabditis elegans Using the Seahorse XF24. Bio Protoc. 2019 Jul 5;9(13):e3288. doi: 10.21769/BioProtoc.3288. PMCID: PMC7854111.
Verheijen BM, Vermulst M, van Leeuwen FW. Somatic mutations in neurons during aging and neurodegeneration. Acta Neuropathol. 2018 Jun;135(6):811-826. doi: 10.1007/s00401-018-1850-y. Review. | PDF
C. Fritsch, JF Gout, M. Vermulst. Transcription errors: A new horizon for mutation research. J Vis Exp. 2018 Sep 13;(139). doi: 10.3791/57731
Meagan J McManus, Hsiao-Wen Chen, Martin Picard, Hans J. De Haas, Prasanth Potluri, Jeremy Leipzig, Atif Towheed, Alessia Angelin, Partho Sengupta, Ryan M. Morrow, Brett A. Kauffman, Marc Vermulst, Jagat Narula, Douglas C. Wallace. Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy. Cell Metabolism, 2019 Jan 8;29(1):78-90.e5. doi: 10.1016/j.cmet.2018.08.002.
S. Haroon, A. Li, C. Fritsch, N. Ericson, J. Alexander-Floyd, B.P. Braeckman, C. Haynes, J. Bielas, T. Gidalevitz, M. Vermulst. Multiple molecular mechanisms rescue mtDNA disease in C. elegans. Cell Reports, Mar 20;22(12):3115-3125. PMID: 29562168 | PDF
J.-F. Gout, Weiyi Li, C. Fritsch, A. Li, S. Haroon, L. Singh, D. Hua, H. Fazelina, Z. Smith, S, Seeholzer, K. Thomas, M. Lynch, M. Vermulst. The landscape of transcription errors in eukaryotic organisms. Science Advances, published online, October 20th 2017, Vol. 3. No. 10, e1701484. PMID: 29062891 | PDF
Someya S, Kujoth GC, Kim MJ, Hacker TA, Vermulst M, Weindruch R, Prolla TA. Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice. PLoS One. 2017 Feb 3;12(2):e0171159. doi: 10.1371/journal.pone.0171159. eCollection 2017. | PDF
Haroon S, Vermulst M. Linking mitochondrial dynamics to mitochondrial protein quality control. Curr Opin Genet Dev. 2016 Jun;38:68-74. doi: 10.1016/j.gde.2016.04.004. Review. | PDF
Vermulst M, Denney AS, Lang MJ, Hung CW, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Cyr D, Kaeberlein M, Strathern JN, Duncan MC and Erie D. Transcription errors induce proteotoxic stress and shorten cellular lifespan. (Nature Communications, 6, article 8065, Aug. 25, 2015) | PDF
Vermulst M, Khrapko K and Wanagat J. (2012) Mitochondrial mutagenesis in aging and disease. Book chapter for Mutagenesis, ISBN 978-953-51-0707-1 | PDF
Ericson N, Kulawiec M, Vermulst M, Sheahan K, O’Sullivan J, Salk J and Bielas JH. (2012) Decreased mitochondrial DNA mutagenesis in human colorectal cancer. PLoS Genetics 8, e1002689. doi: 10.1371/journal.pgen.1002689. PMCID:PMC3369930. | PDF
Chen HC*, Vermulst M*, Wang YE, Prolla TA, McCaffery MJ and Chan DC. (2010) Mitochondrial fusion is required for mtDNA stability and tolerance of mtDNA mutations. Cell 141, 280‐289. PMCID: PMC2858759 * equal contributors | PDF
Vermulst M, Wanagat J and Loeb LA. (2009) On mitochondria, mutations, and methodology. Cell Metabolism 10, 437. PMID: 19945399 | PDF
Dai D, Santana LF, Vermulst M, Tomazeva DM, Emond MJ, Macoss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC and Rabinovitch PS (2009). Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation 119, 2789-2797. PMCID: PMC2858759 | PDF
Vermulst M, Bielas, JH and Loeb, LA. (2008) Quantification of mutation in the mitochondrial genome. Methods 46, 263‐268. PMCID:PMC2615251 | PDF
Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA and Loeb LA. (2008) DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nature Genetics 40, 392-394. PMID: 18311139 | PDF
Vermulst M, Bielas JH, Kujoth GC, Ladiges WG, Rabinovitch PS, Prolla TA and Loeb LA. (2007) Mitochondrial point mutations do not limit the natural lifespan of mice. Nature Genetics 39, 540-543. PMID: 17334366 | PDF
Associated Commentary: Mitochondrial DNA mutations and aging: a case closed? Konstantin Khrapko and Jan Vijg. (2007) Nature Genetics 39, 445-446.