Research in the Benayoun lab focuses on the study of how aging influences genomic regulation, and in return, how modulation of the epigenome and transcriptome can influence the aging process. To study this question, we use a unique combination of high-throughput ‘omics’ approaches, machine-learning, and experimental validation in vertebrate aging models (e.g. mouse, African turquoise killifish, etc.). Our goal is to discover novel target genes and pathways playing a fundamental role in healthy and pathological aging by leveraging the power of big data.

The Benayoun lab is part of the USC Leonard Davis School of Gerontology, is affiliated to the Department of Molecular and Computational Biology of the USC Dornsife College of Letters, Arts and Sciences, Department of Biochemistry and Molecular Medicine at the USC Keck School of Medicine, USC Stem Cell and the USC Norris Comprehensive Cancer Center.