Publications

2019

  • Benayoun BA*, Pollina E, Singh PP, Mahmoudi S, Harel I, Casey K, Dulken B, Kundaje A, and Brunet A*. Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses (2019). Genome Research, 29, 697-709 *co-corresponding authors Pubmed | PDF
  • Lai RW*, Lu R*, Danthi PS, Bravo JI, Goumba A, Sampathkumar NK, and Benayoun BAMulti-level remodeling of transcriptional landscapes in aging and longevity (2019). BMB reports52, 86-108. Pubmed | PDF

2018

  • Kim KH, Son JM, Benayoun BA, and Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress (2018). Cell Metabolism, 28, 516-524. (featured in a preview, in Science Signaling, and on the school WebsitePubmed | Pdf
  • Ucar D and Benayoun BA. Chapter 1 – Aging Epigenetics: Changes and Challenges (2018), in Epigenetics of Aging and Longevity – Translational Epigenetics Vol 4, Pages 3–32. Publisher | Pdf

2017

  • Contrepois K*, Coudereau C*, Benayoun BA, Schuler N, Roux PF, Bischof O, Courbeyrette R, Carvalho C, Thuret JY, Ma Z, Derbois C, Nevers MC, Volland H, Redon C, Bonner W, Deleuze JF, Wiel C, Bernard D, Snyder MP, Rübe C, Olaso R, Fenaille F and Mann C. Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression (2017). Nature Communications14995, 10.1038/ncomms14995.  Pubmed | PDF

2016

  • Kurum E, Benayoun BA, Malhotra A, George J and Ucar D. Computational inference of a genomic pluripotency signature in human and mouse stem cells (2016). Biology Direct11:47, doi: 10.1186/s13062-016-0148-z. Pubmed | PDF

2015

  • Valenzano D*, Benayoun BA*, Singh PP*, Zhang E, Etter PD, Hu CK, Clément-Ziza M, Willemsen D, Cui R, – Harel I, Machado B, Lee MC, Sharp SC, Bustamente C, Beyer A, Johnson EA, and Brunet A. The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan (2015). Cell163, 1539-1554. *equal contribution (highlighted in a Preview: Cell163, 1312-1313) Pubmed | PDF | Genome Browser
  • Pech MF, Garbuzov A, Hasegawa K, Sukhwani M, Zhang RJ, Benayoun BA, Brockman SA, Lin S, Brunet A, Orwig KE, and Artandi SE. High telomerase is a hallmark of undifferentiated spermatogonia and is required for maintenance of male germline stem cells (2015). Genes and Development29, 1-15. Pubmed | PDF
  • Schaffer BE, Levin RS, Hertz NT, Maures TJ, Schoof ML, Hollstein PE, Benayoun BA, Banko MR, Shaw RJ, Shokat KM, Brunet A. Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction (2015). Cell Metabolism22, 907-921. Pubmed | PDF
  • Benayoun BA*, Pollina EA*, and Brunet A. Epigenetic regulation of ageing: linking environmental inputs to genomic stability (2015). Nature Reviews Molecular and Cellular Biology16, 593-610. *equal contribution (highlighted in F1000)  Pubmed | PDF
  • Harel I, Benayoun BA, Machado B, Singh PP, Hu CK, Pech MF, Zhang E, Fullhart SC, Artandi SE, and Brunet A. Rapid exploration of aging and disease-related genes in a naturally short-lived vertebrate (2015). Cell160, 1013-1026. (highlighted in a Preview: Cell,160, 814-815) (highlighted in F1000) Pubmed | PDF

2014

  • Kareta MS, Gorges LL, Hafeez S, Benayoun BA, Zmoos AF, Cecchini MJ, Spacek D, Batista LFZ, O’Brien M, Ng YH, Ang CE, Vaka D, Artandi SE, Dick FA, Brunet A, Sage J, and Wernig M. Inhibition of Pluripotency Networks by the Rb Tumor Suppressor Restricts Reprogramming and Tumorigenesis (2014). Cell Stem Cell16, 39-50. Pubmed | PDF
  • Benayoun BA*, Pollina EA*, Uçar D*, Wong ED, Mancini E, Mahmoudi S, Hitz BC, Devarajan K, Gupta R, Rando TA, Baker JC, Snyder MP, Cherry JM, and Brunet A. H3K4me3 breadth is linked to cell identity and transcriptional consistency (2014). Cell158, 673-688. *equal contribution. Correction inCell, 2015, 163, 1281-1286. (highlighted in F1000Pubmed | PDF  | BDDB
  • Maures TJ, Booth L, Benayoun BA, Izrayelit Y, Schroeder F and Brunet A. Males shorten the lifespan of C. elegans hermaphrodites via secreted compounds (2014). Science343, 541-544. (highlighted in F1000Pubmed | PDF

2013

  • Benayoun BA*, Anttonen M*, L’hôte D, Bailly-Bechet M, Andersson N, Heikinheimo M and Veitia RA. Adult ovarian granulosa cell tumor transcriptomics: prevalence of FOXL2 target genes misregulation gives insights into the pathogenic mechanism of the p.Cys134Trp somatic mutation (2013). Oncogene32, 2739-2746. *equal contribution Pubmed | PDF

2012

  • L’hôte D, Georges A, Todeschini AL, Kim JH, Benayoun BA, Bae J and Veitia RA. Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles (2012). Human Molecular Genetics21, 3264-3274.Pubmed | PDF
  • Caburet S, Georges A, L’hôte D, Todeschini AL, Benayoun BA and Veitia RA. The transcription factor FOXL2: At the crossroads of ovarian physiology and pathology (2012). Molecular and Cellular Endocrinology356, 55-64. Pubmed | PDF
  • Lelièvre EC, Benayoun BA, Mahieu L, Roger JE, Sahel JA, Sennlaub F, Veitia RA, Goureau O and Guillonneau X. A Regulatory Domain Is Required for Foxn4 Activity During Retinogenesis (2012). Journal of Molecular Neuroscience46, 315-323. Pubmed | PDF
  • Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli M, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperriere D, Leprince D, de Cristofaro T, Prince KL, Putker M, Del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O’Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner N, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, Lebrun DP, Biswal S, Harvey CJ, Debruyne JP, Hogenesch JB, Hevner RF, Heligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH and Wasserman WW. The Transcription Factor Encyclopedia (2012). Genome Biology13, R24. Pubmed | PDF
  • Benayoun BA and Brunet A. Epigenetic Memory of longevity in Caenorhabditis elegans (2012). Worm1, 77-81. Pubmed | PDF

2011

  • Greer EL, Maures TJ, Ucar D, Hauswirth A, Mancini E, Lim J, Benayoun BA, Shi Y and Brunet A. Transgenerational Epigenetic Inheritance of Longevity in C. elegans (2011). Nature479, 365-371. (highlighted in F1000) Pubmed | PDF
  • Benayoun BA, Caburet S and Veitia RA. Forkhead transcription factors: key players in health and disease (2011). Trends in Genetics27, 224-232. Pubmed | PDF
  • Benayoun BA, Georges AB, L’Hôte D, Andersson N, Dipietromaria A, Todeschini AL, Caburet S, Bazin C, Anttonen M and Veitia RA. Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase (2011). Human Molecular Genetics20, 1673-1686. Pubmed |  PDF
  • Georges AB, Benayoun BA, Marongiu M, Dipietromaria A, L’hôte D, Todeschini AL, Auer J, Crisponi L and Veitia RA. SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies (2011). PLoS ONE6, e25463. Pubmed | PDF

2010

  • Georges AB, Benayoun BA, Caburet S and Veitia RA. Generic binding sites, generic DNA binding domains: where does specific promoter recognition comes from? (2010). FASEB Journal24, 346-356. Pubmed | PDF
  • Benayoun BA*, Caburet S*, Dipietromaria A, Georges AB, D’Haene B, Pandaranayaka PJE, L’Hôte D, Todeschini AL, Krishnaswamy S, Fellous M, De Baere E and Veitia RA. Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G) (2010). PLoS ONE5, e8789. *equal contribution Pubmed | PDF
  • Benayoun BA, Kalfa N, Sultan C and Veitia RA. The Forkhead transcription factor FOXL2: a novel tumor suppressor gene? (2010).BBA reviews on Cancer1805, 1-5. Pubmed | PDF

2009

  • Dipietromaria A, Benayoun BA, Todeschini AL, Rivals I, Bazin C and Veitia RA. Towards a functional classification of pathogenic FOXL2 mutations using transactivation reporter systems (2009). Human Molecular Genetics18, 3324-3333. Pubmed | PDF
  • Kalfa N, Veitia RA, Benayoun BA, Boizet-Bonhoure B and Sultan C. The new molecular biology of granulosa cell tumors of the ovary (2009), Genome Medicine1, 81. Pubmed | PDF
  • Laissue P, Lakhal B, Benayoun BA, Dipietromaria A, Braham R, Elghezal H, Philibert P, Saâd A, Sultan C, Fellous M, and Veitia RA. Functional evidence implicating FOXL2 in non-syndromic premature ovarian failure and in the regulation of the transcription factor OSR2 (2009). Journal of Medical Genetics46, 455-457. Pubmed | PDF
  • Benayoun BA and Veitia RA. A post-translational modification code for transcription factors: sorting through a sea of signals (2009). Trends in Cell Biology19, 189-197. Pubmed | PDF
  • Benayoun BA, Batista F, Auer J, Dipietromaria A, L’hôte D, De Baere E and Veitia RA. Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations (2009). Human Molecular Genetics18, 632-644. Pubmed | PDF

2008

  • Benayoun BA*, Caburet S*, Dipietromaria A*, Bailly-Bechet M, Batista F, Fellous M, Vaiman D and Veitia RA. The identification and characterization of a FOXL2 response element provides insights into the pathogenesis of mutant alleles (2008). Human Molecular Genetics17, 3118-3127. *equal contribution Pubmed | PDF
  • Nallathambi J, Laissue P, Batista F, Benayoun BA, Lesaffre C, Moumné L, Pandaranayaka PJE, Usha K, Krishnaswamy S, Sundaresan P and Veitia RA. Differential Functional Effects of Novel Mutations of the Transcription Factor FOXL2 in BPES Patients (2008). Human Mutation29, E123-E131. Pubmed | PDF
  • Benayoun BA, Auer J, Caburet S and Veitia RA. The post-translational modification profile of the forkhead transcription factor FOXL2 suggests the existence of parallel processive modification pathways (2008). Proteomics8, 3118-3123. Pubmed | PDF
  • Moumné L, Batista F, Benayoun BA, Nallathambi J, Fellous M, Sundaresan P and Veitia RA. The mutations and potential targets of the forkhead transcription factor FOXL2 (2008). Molecular and Cellular Endocrinology282, 2-11. Pubmed | PDF