Research in the Benayoun lab focuses on the study of how aging influences genomic regulation, and in return, how modulation of the epigenome and transcriptome can influence the aging process, as well as the development of age-related disease (e.g. Alzheimer’s). To study this question, we use a unique combination of high-throughput ‘omics’ approaches, machine-learning, and experimental validation in vertebrate models (e.g. mouse, African turquoise killifish, human cells, etc.). Our goal is to discover novel target genes and pathways playing a fundamental role in healthy and pathological aging by leveraging the power of big data.

The Benayoun lab is part of the USC Leonard Davis School of Gerontology, is affiliated to the Department of Cancer Biology at the USC Keck School of Medicine, USC Stem Cell ,  the USC Norris Comprehensive Cancer Center and the Department of Pharmacology and Pharmaceutical Sciences at the USC Mann School of Pharmacy and Pharmaceutical Sciences.