Faculty

Kai Zhou, PhD

Fellow, Buck Institute for Research on Aging
Adjunct Fellow of Gerontology

Overview

Proteins in a cell are metastable and not only threatened by the crowded cellular environment, but also affected by mutations, mistakes in translation and posttranslational modifications, and unpredictable environmental stresses. Proteins tend to misfold with age, which impairs protein homeostasis and is believed to be an underlying cause for many age-related diseases, including Alzheimer’s and Parkinson’s. Protein homeostasis (proteostasis), maintained through balancing protein folding and misfolding, is the key for biological systems to live long and prosper, as almost all cellular functions are fulfilled by specific proteins.

The Zhou lab studies mechanisms underlying the cellular aging process, with a particular emphasis on proteostasis. We study protein folding and misfolding in both young and aging cells, with the goal of understanding the events that lead to the loss of proteostasis during cellular aging and disease as well as identifying mechanisms that can be exploited to rejuvenate aging cells. Our lab uses the budding yeast Saccharomyces cerevisiae to study these topics systematically and comprehensively at the molecular and cellular levels. Budding yeast has been proven to be a great model system for research on cellular aging and revealed longevity mechanisms that are highly conserved in metazoan. By leveraging genetic tools and libraries, we hope to progress quickly on projects to provide insights for fundamental biological questions. We are also developing new methodologies and platforms to broaden our technology portfolio that can be unleashed to break through current limitations in the field and improve our understanding of aging and age-related diseases.