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Gerontology Honors Student Elaine Roh wins 1st Prize in the University’s Undergraduate Symposium

By Featured, Honors and Awards, Mitochondria, Student Profile

With guidance from Dr. Sean Curran and Dr. ShanShan Pang of the USC Leonard Davis School of Gerontology, gerontology honors student, Elaine Roh made a lasting impression on the judges with her study entitled: Adaptive Capacity to Bacterial Diet Modulates Aging in C. elegans. [ Read a Summary of her Research]

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Dynamic Duo

By Featured, Mitochondria

Glousman and Min Award Gerontology undergrads Brandon Glousman and Jung-Gi Min did not rest on their laurels after earning scholarships from the Summer Undergraduate Research Associates Program and the USC Provost’s Undergraduate Research Fellowship. Instead, they went on to also win first prize in the life sciences division of USC’s 15th Annual Undergraduate Symposium for Scholarly and Creative Work.

“I’m so proud of them for so many reasons, including their genuine interest in research, their excellent work ethic and their great teamwork,” said their faculty sponsor, Changhan David Lee, of the USC Leonard Davis School. “Their almost palpable excitement of discovery is a great source of enthusiasm for the lab, and they’re also fun, great guys to have around.”

Glousman and Min’s study, titled, “Targeting Cancer Metabolism: The Effects of a Novel Mitochondrial-Derived Peptide on Breast Cancer Progression” showed the possibility of inhibiting the proliferation of cancer by targeting metabolism, as well as the potential role of the mitochondria as a significant communicator in the progression of cancer.

“The experiment took a lot of hard work and long hours, but it all paid off. I am so grateful to have joined such a supportive lab and have been under the guidance of our amazing mentor, Dr. Lee,” Glousman said. “He has provided us with a unique opportunity to dive deeply into research to the extent expected of PhD candidates.”

“I am really honored that we won in the midst of such amazing projects from all over the university,” Min said. “Dr. Lee demands excellence and does not cut us any slack for being ‘undergraduate researchers’ and I am so proud to have represented the School of Gerontology and our lab as centers of undergraduate research.”

The duo plans on expanding their research to see if the mitochondrial-derived peptide, named MOTS-c, has similar effects on the progression of prostate cancer as well.

“Besides being remarkable rising scientists and scholars, Brandon and Jung-Gi exemplify the highest ideals of our School and our field itself,” said Pinchas Cohen, dean of the USC Leonard Davis School. “We fully expect these exceptional young men to change the face of gerontology and look forward to what they accomplish next.”

Two Top-Tier Scientists

By Featured, Mitochondria
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Krista Garcia, photo credit Morgan Levine

In honor of their outstanding accomplishments and limitless potential, two USC Leonard Davis School doctoral students ended the school year with a major reason to celebrate.

Krista Garcia was one of only two social scientists in the last seven years to win the R36 National Institute on Aging (NIA) Aging Research Dissertation Award, which supports two years of dissertation work as well as providing funds for additional expenses.

“Nearly half of men and a third of women will develop cancer in their lifetime. However, it is unclear what the long-term effects of cancer and its treatment are on survivors,” Garcia said. “I hope to address this research void and to improve our understanding of the adverse physical and cognitive health outcomes following a cancer diagnosis in older adults, which can inform interventions and help identify at-risk groups.”

Crediting her advisor, Eileen Crimmins, as well as the insight and guidance of postdoctoral researcher Jennifer Ailshire and research administrator/program manager Linda Hall, Garcia expressed gratitude for the Multidisciplinary Research Training in Gerontology Program.

“The success of my application is attributed to my outstanding mentoring team and to the strong institutional support I receive here at the USC Leonard Davis School,” Garcia said. “I am very grateful and very proud.”

Laura Corrales-Diaz Pomatto, photo credit Christine McDowell/The Image Artist

Laura Corrales-Diaz Pomatto, photo credit Christine McDowell/The Image Artist

Fellow USC Leonard Davis School doctoral student Laura Corrales-Diaz Pomatto earned a National Science Foundation Graduate Research Fellowship, which will support three years of research with the possibility of additional expenses.

“This will provide me the opportunity to focus entirely upon research and to further explore the role of a mitochondrial stress response protein known as the Lon protease,” Corrales-Diaz Pomatto said. “I plan to solve the mystery of how it is regulated and to achieve one of my major goals: to be a part of a collaboration between gerontology and engineering to improve the aging process.”

Attributing enormous impact to the guidance of her mentor, Kelvin J.A. Davies, vice-dean of the USC Leonard Davis School, as well as to the discipline and camaraderie of rowing on USC’s crew team, Corrales-Diaz Pomatto says that being a Trojan has shaped her in more ways than she can count.

“The concept of ‘Fight On’ has become more than a school motto,” Corrales-Diaz Pomatto said. “It embodies how I hope to approach life—that regardless the challenges, I will continue to persevere.”

“With sterling records as students and scientists, both Krista and Laura represent the highest ideals of USC as well as those of the field of gerontology itself,” said USC Leonard Davis School dean Pinchas Cohen. “We are so proud that the National Institute on Aging and the National Science Foundation recognized how exceptional these two women are, and we can’t wait to see what they accomplish next.”

What’s Hot? Aging Research!

By Featured, Mitochondria

Trojans of all scientific stripes shone at the USC Leonard Davis School of Gerontology’s fourth annual interdisciplinary symposium, “What’s Hot in Aging Research at USC.”

Organized by USC Leonard Davis assistant professor Sean Curran and associate dean Maria Henke, the conference was held on Monday, April 22 under the subtitle “Integrated Approaches to the Study of Aging.”

“I’m so delighted to see such an incredible turnout to this event. There’s so much exciting new work being done at our School and at USC,” said Davis School dean Pinchas Cohen. “Aging is at the forefront of what we think about as a society; it’s where our resources are being channeled; it is the lens through which we see the challenges and opportunities of the future.”

Curran chaired the first session, entitled “Nutrition, Metabolism, Aging,” which examined the biology and genetics behind longevity. Fielding questions about growth hormone injections, organic food and the role of the mitochondria in cellular aging, USC Leonard Davis Valter Longo and David Lee as well as Biological Science’s John Tower provided the scientific basis for the day’s remaining programs.

The second session, “The Future of Aging,” contained speakers from the USC Leonard Davis School of Gerontology, chaired by Susan Enguídanos, who began the panel with a discussion of end-of-life care trends, transitions and trepidations. Next up was Elizabeth Zelinski, who discussed the brain’s changing cognition with age after describing the Flynn Effect, which shows steady generational improvements for 18-year-olds in their ability to do well on IQ tests.

“So, like you’ve always thought, you are indeed smarter than your parents,” she joked. “Like your kids think…they’re probably smarter than you.”

The panel closed with Tara Gruenewald discussing the role of generativity—or the care, concern and cultivation directed towards younger generations—in helping people age with greater reports of happiness and health.

Before breaking for lunch, Cohen surprised everyone by presenting the Dean’s Medallion to attendee Mike Yamano, chancellor of Tokyo’s Yamano College.

“This is the greatest honor we can give to our partners and supporters and I am honored to recognize the distinguished career and contributions of Mike Yamano. A true gerontology ambassador, he has helped revolutionize the field with his innovative recognition of the link between aging and aesthetics,” Cohen said. “To quote Mike’s lifelong friend and the head of the USC Leonard Davis School Board of Councilors, Dr. Richard King, ‘Mike is a visionary, an entrepreneur and, most of all, a person with a fine spirit. I am so proud to have him and Yamano College associated with the USC Leonard Davis School.’”

“Dr. Cohen, USC and attendees: I am so honored. Thank you—this is indeed a surprise,” Yamano said. “I have been surprised many times in my 77 years, but the best and most beautiful surprise is to see so many wonderful people studying gerontology.”

After a lunchtime networking session, the USC Leonard Davis School’s Caleb Finch discussed his recent “mummy study” of atherosclerosis. He also chaired the third session, “The Aging Brain,” which included his Davis colleague Mara Mather discussing the positivity effect of older adults’ cognition as well as Dion Dickman from Neuroscience covering homeostasis and plasticity.

The final session, “Emerging Scholars,” was moderated by Curran, who gave USC Leonard Davis School postdoctoral researchers and doctoral students an opportunity to present their work. Mafalda Cacciottolo discussed APOE isoforms, Jeff Laguna discussed a pain management smartphone app and Morgan Levine discussed her study on the unique health resilience of long-lived smokers. As the conference wrapped up, Jennifer Ailshire presented her study on air pollution and the aging body and brain, which was particularly of interest to Southern Californians.

“LA has the highest level of fine particulates in the country. We’re all a vulnerable population. There’s a daily growing body of evidence showing the harmful effects of particulate air pollution, including respiratory and cardiovascular damage and compromised brain health and development,” Ailshire said. “The good news is that this is all preventable. We can all do something about air pollution. We all deserve to breathe clean air, regardless of where we live.”

Once more, “What’s Hot in Aging Research” helped to enlighten and empower attendees not only to appreciate the amazing aging-related work being done across USC’s campus, but to also reaffirm their commitment to their own.

“There’s just something special about the Trojan spirit,” said Cohen. “As always, it’s our pleasure to highlight the world-changing work USC researchers in all disciplines are doing. What’s hot in aging? USC research is!”

Grand Opening

By Featured, Mitochondria

cooper2Although home to the study of aging, the USC Leonard Davis School of Gerontology welcomed the youngest lab facility on campus on Friday, March 1.

After a lengthy construction process that converted the basement of the Andrus Gerontology Center into a state-of-the-art lab complete with offices and meeting rooms, Pinchas Cohen cut the ribbon on his new lab, thanking the provost’s office, faculty, staff and students, as well as the construction team.

“This is the nicest lab I’ve ever seen and it’s remarkable how construction was completed on time,” Cohen said. “Our next goal is to revamp our third-floor labs to surpass this one.”

Marking almost a year since his installation as dean of the USC Leonard Davis School and executive director of the Andrus Gerontology Center, Cohen then gave attendees a tour of the lab, which included specially tiled floors in the shape of mitochondria.

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“I am thrilled to begin a new chapter in my research as well as in the history of the USC Leonard Davis School,” Cohen said. “This wonderful facility will serve as a birthplace of innovation and development as well as a beacon of the world-class, excellent science for which the USC Leonard Davis School is famous.”

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